Results 61 to 70 of about 1,405,996 (300)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Mosquitoes, Muck, and Mussels: A Look Into Scientific Research
Open Rivers, 2018 The aspiring young undergraduate scientists envision fieldwork as a romantic escape from the office cubicle, classroom desk, and seemingly endless pile of homework.
Lea Davidson, James Doherty, Laura Gould, and Hayley Stutzman
doaj +1 more source
The Technology of Skill Formation [PDF]
his paper presents formal models of child development that capture the essence of recent findings from the empirical literature on child development.
Flavio Cunha +2 more
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Lab on the River – Snapshots of the St. Anthony Falls Laboratory
Open Rivers, 2018 The St. Anthony Falls Laboratory (SAFL), which falls under the College of Science and Engineering at the University of Minnesota (UMN), is one of several historic buildings along the Minneapolis riverfront.
Barbara Heitkamp
doaj +1 more source
Japanese beetle feeding and survival on apple fruits
Bioscience Journal, 2020 Popillia japonica (Coleoptera: Scarabaeidae), Japanese beetle, is a polyphagous pest of many crops. In these crops, including apple, it acts primarily as a defoliator, causing economic damages. The objectives were to determine the ability of P.
Evaldo Martins Pires, Robert Lee Koch
doaj +1 more source
A Demographic and Economic Profile of Duluth, Minnesota, and Superior, Wisconsin [PDF]
, 2017 In this brief, authors Andrew Schaefer, Marybeth Mattingly, and Douglas Gagnon present a demographic and economic profile of Duluth, Minnesota, and Superior, Wisconsin, with a specific focus on families with children.
Gagnon, Douglas J. +2 more
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Learning from the Dakota: Water and Place
Open Rivers, 2018 These videos and audios are from Bdote Memory Map. The deep mapping project created by Allies: media/art is a partnership project with the Minnesota Humanities Center.
Mona Smith
doaj +1 more source
Giving in Minnesota, 2012 Edition [PDF]
, 2012 The Minnesota Council on Foundations (MCF) has produced its Giving in Minnesota, 2012 Edition research report, the most comprehensive analysis of charitable giving in the state.
Anne Bauers, Anne Graham, Wendy Wehr
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