Results 121 to 130 of about 30,696 (201)

Minocycline infusion sclerotherapy for infected hepatic cysts in a patient with autosomal dominant polycystic kidney disease: a case report and literature review. [PDF]

CEN Case Rep
Inamura Y, Fukunaga S, Matsuo N, Maruyama Y, Yokoo T.   +4 more
europepmc   +1 more source

Glymphatic System Dysfunction in Central Nervous System Diseases

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Glymphatic Dysfunction in Neurological Disorders: The glymphatic system is a brain‐wide clearance system that removes neurotoxic waste via AQP4‐mediated CSF‐ISF exchange. Dysfunction through AQP4 mislocalization, BBB injury, and inflammation annihilates clearance and causes acute (stroke, TBI) and chronic disease.
Anwar Zahran, Omar Abu‐Khazneh, Mohammad Bdair, Orabi Hajjeh, Mohammed AbuBaha, Waseem Shehadeh, Ameer Awashra, Ibrahim Alazizi, Raya Fuqha, Sakeena Saife, Hasan Fuqha, Fathi Milhem, Husam Hamshary, Dana Abuzahra, Umar Shuaib   +14 more
wiley   +1 more source

Mutant KRAS in brain endothelial cells promotes vascular inflammation and impairs vascular integrity in brain arteriovenous malformation. [PDF]

J Cereb Blood Flow Metab
Park JE, Freeman BH, Park H, Kim S, Bafor AE, Myint O, Gao S, Xu Z, Körbelin J, Aronowski J, Chen PR, Kim E, Park ES.   +12 more
europepmc   +1 more source

Midkine Overexpression Promotes Functional Recovery After Spinal Cord Injury by Enhancing Microglial Efferocytosis Via LRP‐1

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Midkine (MDK) promotes functional recovery after spinal cord injury by enhancing microglial efferocytosis, reducing neuroinflammation, and decreasing neuronal apoptosis. Overexpression of MDK activates the AKT/mTOR pathway, upregulates LRP‐1 and BDNF, and drives microglia toward an anti‐inflammatory phenotype.
Yu Wang, Lu Fang, Chenyuan Zhai, Jili Cai, Xiangzhe Li, Lijuan Zong, Yao Geng, Chenchen Zhu, Cheng Sun, Manyu Dong, Yilun Qian, Yan Liu, Ying Huang, Zun Wang, Tong Wang, Wen‐Tao Liu, Qi Wu   +16 more
wiley   +1 more source

Spontaneous pneumothorax in a patient with tuberculosis-induced destroyed lung successfully treated with autologous blood and minocycline pleurodesis: a case report. [PDF]

AME Case Rep
Koh E, Sekine Y.
europepmc   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Rationale and Study Design to Assess the Efficacy and Safety of Minocycline in Patients with Moderate to Severe Acute Ischaemic Stroke (EMPHASIS). [PDF]

Stroke Vasc Neurol
Lu Y, Guan L, Zhang M, Yang Q, Qiu B, Zhou D, Wang Y, Pan Y, Wang L, Zhou X, Qu H, Liao X, Liu L, Zhao X, Bath PM, Johnston SC, Amarenco P, Wang Y, Wang Y.   +18 more
europepmc   +1 more source

Global pharmacovigilance analysis of antimicrobials used in periodontal therapy: safety profiles of minocycline, doxycycline, and chlorhexidine. [PDF]

Head Face Med
Ning W, Huang X, Li S, Jiang L, Reissmann DR, Kreher D, Schmalz G, Chu H, Huang S.   +8 more
europepmc   +1 more source

Plasma‐Assisted KR‐12 Conjugated PLGA Nanofibers With Dual Osteogenic and Biofilm‐Inhibitory Activity

Journal of Biomedical Materials Research Part A, Volume 114, Issue 3, March 2026.
ABSTRACT Multidrug‐resistant bacterial infections pose a significant challenge in bone tissue engineering, primarily due to the formation of biofilms on implant surfaces, which can impede osteointegration. KR‐12, a cationic antimicrobial peptide (AMP) with dual osteoinductive and biofilm‐inhibitory properties, represents a promising strategy to address
Günnur Pulat, Eda Bilgiç, Buse Sezer
wiley   +1 more source