Results 91 to 100 of about 1,710,065 (268)
On matroid minors that guarantee their duals as minors
Advances in Applied Mathematics, 2015 A natural question for matroids follows: Which matroids N guarantee that, when present as minors in a larger matroid M, their duals are present as minors? The main results of this paper focus on this question with the additional constraint that N and M are 3-connected. We also solve the problem with other connectivity and representability constraints.
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Frammenti di tempo e spazio in alcuni personaggi di Luigi Pirandello
Études romanes de Brno, 2009 In twentieth century Italian literature, the conception of time goes towards subjectivity and gradually goes away from the chronological order of the events.
Michele Sità
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Some Problems of Pedophilia Crimes Delimitation
Vestnik Omskoj Ûridičeskoj Akademii, 2013 The article deals with the analysis of the changes contributed by the lawmaker to the RF Criminal Code. Here are distinguished contradictory and collision norms, the problems of their qualification. Some scientific points of view are quoted.
Kuznetsova I. A. , Pestereva Yu. S.
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Two miniatures relating the 2 × 2 minors of a square matrix and the symmetric group
Extracta MathematicaeIn the first miniature we recall a puzzle proposed by Martin Gardner in 1957 and refreshed by Blasco in 2014. We prove some properties of the matrices involved. We show that Gardner magical matrices are tropically singular.
Marı́a Jesús de la Puente
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
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