Results 91 to 100 of about 196,839 (313)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2013 The expression “invisible minorities” was originally used in a specific, relatively narrow context of sexual and gender minorities. However, as these communities have become increasingly visible while their social and legal situation is seriously ...
core +1 more source
Subscapularis minor – an analogue of the Teres minor?
Orthopaedics & Traumatology: Surgery & Research, 2013 The purpose of this study was to determine the role of the subscapularis (SSC) in forward flexion. We hypothesized that the inferior part of the SSC has a main role in the ability to preserve forward flexion in cases of anterosuperior rotator cuff tears.Active forward flexion of the shoulder was prospectively evaluated in patients presenting with Grade
Collin, Philippe +3 more
openaire +3 more sources
Religious minorities in Pakistan
, 2002 Report written for Minority Rights Group International. This report aims to enhance understanding of religious minorities in Pakistan and increase awareness of the need for the protection of minority and gender-based rights across communities.
Malik, I.H
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Social Determinants of Labor Market Status of Ethnic Minorities in Britain [PDF]
The labor market behavior of ethnic communities in advanced societies and the social determinants of labor market outcomes of minority groups are important empirical issues with significant policy consequences.
Mariapia Mendola, Martin Kahanec
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2015 There are ten Muslim minorities in China, of which the most populous and important (in terms of their impact on China's history, contemporary politics, and society) are the culturally Chinese Hui and the Turkic Uighurs.
Mackerras, Colin, Colin Mackerras
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source