Results 121 to 130 of about 743,854 (316)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Analyzing risk factors for second malignancies in early gastric carcinoma from the SEER database

Scientific Reports
This retrospective study analyzed a large population of gastric cancer (GC) patients treated between 2010 and 2015 to investigate the clinical features and predictive risk factors for developing secondary primary malignancies (SPMs).
Lei Song, Fei Zhao, Lijing Zhang, Zhifang Zhao, Long Jin, Yu Zhao, Jin Zhao   +6 more
doaj   +1 more source

Developing world: The minority minority [PDF]

Nature, 2015
Women are under-represented in physical sciences and in science in the developing world. Meet three who beat both sets of odds.
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Speaking My Language : Languages Other Than English, Educational Attainment Levels, and Median Incomes in South Carolina's Minority Communties [PDF]

, 2022
This report examines the interplay between educational attainment and linguistic ability for South Carolina's racial and ethnic minority populations.
South Carolina Commission for Minority Affairs, Pierce-Mosquera, Mateo, Fenton, Robert P.   +2 more
core  

Clinical and sociodemographic characteristics associated with health-related quality of life among older breast cancer survivors

Women's Health
Background: Health-related quality of life (HRQoL) measures may help incorporate patient preferences and deliver individualized care for older breast cancer survivors.
Jacob Schneider, Kaitlyn M. Wojcik, Emma Tian, Oliver W. A. Wilson, Jinani Jayasekera   +4 more
doaj   +1 more source

Eragrostis minor subsp. minor

, 2020
Published as part of Buldrini, Fabrizio, Gentilini, Matteo, Bruni, Cinzia, Santini, Claudio, Alessandrini, Alessandro & Bosi, Giovanna, 2020, Flora vascolare spontanea della città di Modena: analisi del centro storico, pp. 3-56 in Natural History Sciences 7 (1) on page 30, DOI: 10.4081/nhs.2020.443, http://zenodo.org/record ...
Buldrini, Fabrizio, Gentilini, Matteo, Bruni, Cinzia, Santini, Claudio, Alessandrini, Alessandro, Bosi, Giovanna   +5 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Arizona minority student success report (2003) [PDF]

, 2003
The Arizona Minority Education Policy Analysis Center is a policy center of the Arizona Commission for Postsecondary Education. Its mission is to stimulate, through studies, statewide discussion, and debate, constructive improvement of Arizona minority ...

core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source