Results 101 to 110 of about 61,044 (249)

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Proximity to Industrial Releases of Toxins and Childhood Respiratory, Developmental, and Neurological Diseases: Environmental Ascription in East Baton Rouge Parish [PDF]

Recent research by Legot et al. (2010a, 2010b) has identified East Baton Rouge Parish (EBR) as a locus of particularly high volumes of emissions of developmental neurotoxins, i.e., those toxins that put children’s health and, especially, learning ...
John Shandra, Bruce London, Cristina Legot   +2 more
core  

Introduction of a Guide to Enhance Risk Communication Among Low-Income and Minority Populations

, 2011
Low-income populations, especially those belonging to minority groups, are among the most vulnerable groups before, during, and after a natural disaster.
Payam Sheikhattari, Randy Rowel, Tanyka M. Barber, Myrtle Evans-Holland   +3 more
core   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Reducing health inequalities through general practice: a realist review and action framework

Health and Social Care Delivery Research
Background Socio-economic inequalities in health have been in the public agenda for decades. General practice has an influential role to play in mitigating the impact of inequalities especially regarding chronic conditions.
Anna Gkiouleka, Geoff Wong, Sarah Sowden, Isla Kuhn, Annie Moseley, Sukaina Manji, Rebecca R Harmston, Rikke Siersbaek, Clare Bambra, John A Ford   +9 more
doaj   +1 more source

Human spotted fever group Rickettsia seroprevalence and associated epidemiologic factors among diverse, marginalized populations in South Carolina

Ticks and Tick-Borne Diseases
Illness caused by spotted fever group Rickettsia (SFGR) is increasing nationally, with affluent, white residents most likely to be diagnosed. The common under-representativeness of marginalized populations in research studies and these vulnerable ...
Lídia Gual-Gonzalez, Stella C.W. Self, Madeleine Meyer, Omar Cantillo-Barraza, Myriam E. Torres, Melissa S. Nolan   +5 more
doaj   +1 more source

Polydopamine‐Wool Textiles for Sustainable Interfacial Solar Vapor Generation

Advanced Science, EarlyView.
A natural wool textile engineered for high solar absorbance and a fast‐wicking structure serves as a highly efficient, single‐layer system for interfacial solar vapor generation (ISVG). This integrated evaporator seamlessly couples rapid water transport with continuous evaporation. Ultimately, this sustainable photothermal design offers a scalable, eco‐
Kyuin Park, Jintong Gao, Hansadi Jayamaha, Yipu Wang, Mia Bressler, Lenan Zhang, Larissa M. Shepherd   +6 more
wiley   +1 more source

Addressing the critical palliative care gaps in ethnic minority regions of low- and middle-income countries: a focus group study

BMC Medicine
Background Palliative care is an important approach to relieving suffering and improving quality of life for people living with serious illness. Yet its development remains challenging in many low- and middle-income countries, particularly among ...
Hongzhi Wang, Xiangjie Lyu, Xiaogang Wang, Yinshan Tang, Luping Dong, Xin Xiang   +5 more
doaj   +1 more source

Intentional Infection of Vulnerable Populations in 1946-1948

, 2010
Unethical uses of humans as research subjects represent appalling chapters in the history of medicine. 1 To ensure that effective protections against such abuses continue to evolve and improve, it is essential to continue to learn from historical ...
Collins, Francis S, Francis S. Collins, Collins, Francis S., Thomas R. Frieden, Frieden, Thomas R., Frieden, Thomas R   +5 more
core   +1 more source

Couple-level minority stress and mental health among people in same-sex relationships: Extending minority stress theory [PDF]

, 2020
We simultaneously examined the effects of individual- and couple-level minority stressors on mental health among people in same-sex relationships. Individual-level minority stressors emerge from the stigmatization of sexual minority individuals; couple ...
Frost, D, LeBlanc, AJ
core