Results 31 to 40 of about 349,518 (266)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Possibilities and Obstacles to Creating an Iclusive Register of the Intangible Cultural Heritage of the Autonomous Province of Vojvodina – An Anthropological Analysis

Etnoantropološki Problemi, 2020
This paper looks at the current situation of the institutional practice of safeguarding the intangible cultural heritage (ICH) in terms of the idea, put forward in anthropological literature, about the need to establish an inclusive ICH register for the ...
Jelena Ćuković, Miloš Milenković
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Underdiagnosis of Fabry disease in minority ethnic groups

Molecular Genetics and Metabolism Reports
Fabry disease (FD) is a rare, pan ethnic X-linked disorder. We explored ethnic representation in our service and a national patient organisation. An audit of the University Hospitals Birmingham FD cohort revealed that 9 % of index cases are minority ...
Claudia L. Church Smith, Ashwin Roy, Sarah Steeds, Natalie Tuzcuoglu, Christopher Wingrove, Katherine Aitchison, Claire Radford, Laura A. Boyes, Fiona Stewart, Tarekegn Geberhiwot, Richard P. Steeds   +10 more
doaj   +1 more source

The Impact of an Educational Video on Clinical Trial Enrollment and Knowledge in Ethnic Minorities: A Randomized Control Trial

Frontiers in Public Health, 2019
Introduction: Innovative methods to increase awareness about clinical trials and address barriers associated with low participation among racial/ethnic minorities are desperately needed.
Jeannine S. Skinner, Alecia M. Fair, Alexis S. Holman, Alaina P. Boyer, Consuelo H. Wilkins, Consuelo H. Wilkins   +5 more
doaj   +1 more source

Micro-Segregation of Ethnic Minorities in Rome: Highlighting Specificities of National Groups in Micro-Segregated Areas

Land, 2023
This paper aims to study ethnic micro-segregation in Rome, namely, high residential concentrations of ethnic groups at the micro-area level within neighbourhoods with low concentrations of these groups, with a focus on specific situations of spatial ...
Massimiliano Crisci, Michele Santurro
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Scottish survey of diabetes services for minority ethnic groups

BMC Health Services Research, 2006
Background In the UK, all ethnic minority groups have higher rates of diabetes than the general population. Although there have been a number of projects to assess diabetic care amongst minority ethnic groups in the United Kingdom, little is known about ...
Gardee Rafik, Jamieson Joan, Baradaran Hamid R, Knill-Jones Robin P   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source