CircRNA circ-ATAD1 suppresses miR-618 maturation to participate in colorectal cancer [PDF]
BMC Gastroenterology, 2022 Background CircRNA circ-ATAD1 has been characterized as an oncogenic circRNA in gastric cancer, while its role in colorectal cancer (CRC) is unknown. This study was carried out to explore the role of circ-ATAD1 in CRC. Methods Paired CRC and adjacent non-
Li Cao, Guanglong Dong, Huan Li
doaj +2 more sources
Circulating miR-618 Has Prognostic Significance in Patients with Metastatic Colon Cancer [PDF]
Current Oncology, 2021 The present study evaluated the prognostic role of circulating miRNA-618 in patients with metastatic colon cancer (mCC) and whether miR-618 gene rs2682818 single nucleotide polymorphisms (SNP) are associated with colon cancer susceptibility and ...
Maria Radanova +9 more
doaj +2 more sources
Polymorphism rs2682818 participates in the progression of colorectal carcinoma via miR-618-TIMP1 regulatory axis [PDF]
Scientific Reports, 2021 Colorectal carcinoma (CRC) has a high morbidity and mortality. Current studies have confirmed a variety of microRNA polymorphisms were associated with tumor susceptibility, however, the mechanisms are still unknown.
Wei Shao +6 more
doaj +2 more sources
MicroRNAs hsa-miR-618 and hsa-miR-297 Might Modulate the Pleiotropic Effects Exerted by Statins in Endothelial Cells Through the Inhibition of ROCK2 Kinase: in-silico Approach [PDF]
Frontiers in Cardiovascular Medicine, 2021 Several studies show that statin therapy improves endothelial function by cholesterol-independent mechanisms called “pleiotropic effects.” These are due to the inhibition of the RhoA/ROCK kinase pathway, its inhibition being an attractive ...
Karla Leal +3 more
doaj +2 more sources
miR-618: possible control over TIMP-1 and its expression in localized prostate cancer [PDF]
BMC Cancer, 2018 Background The imbalance between the action of the tissue inhibitors of matrix metalloproteinases (TIMPs) and the matrix metalloproteinases (MMPs) is one component of metastasis physiology. TIMP-1 overrides MMP-9 activity in cancer and might be regulated
Renato F. Ivanovic +9 more
doaj +2 more sources
Circulating exosomal microRNA expression patterns distinguish cardiac sarcoidosis from myocardial ischemia. [PDF]
PLoS ONE, 2021 ObjectiveCardiac sarcoidosis is difficult to diagnose, often requiring expensive and inconvenient advanced imaging techniques. Circulating exosomes contain genetic material, such as microRNA (miRNA), that are derived from diseased tissues and may serve ...
Elliott D Crouser +8 more
doaj +3 more sources
Increased Expression of Circular RNA circ_0005230 Indicates Dismal Prognosis in Breast Cancer and Regulates Cell Proliferation and Invasion via miR-618/ CBX8 Signal Pathway [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Circular RNAs (circRNAs) are a class of non-coding RNAs. They have been proved to be critically involved in tumorigenesis and progression of malignancies through competing endogenous RNA (ceRNA) mechanism.
Yi Xu +6 more
doaj +3 more sources
Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population. [PDF]
BMC Genet, 2016 Indexación: Web of ScienceBackground MicroRNAs (miRNAs) are a novel class of endogenous, non-coding, single-stranded RNAs capable of regulating gene expression by suppressing translation or degrading mRNAs.
Morales S +8 more
europepmc +5 more sources
Polymorphism rs2682818 in miR‐618 is associated with colorectal cancer susceptibility in a Han Chinese population [PDF]
Cancer Medicine, 2018 MicroRNAs (miRNAs), endogenous small noncoding RNAs (ncRNAs), play crucial roles in cancer development. Many studies have demonstrated that miRNAs can serve as diagnostic and therapeutic biomarkers for malignancies.
Yuetong Chen +9 more
doaj +2 more sources
Identification of aberrantly expressed lncRNAs and ceRNA networks in multiple myeloma: a combined high-throughput sequencing and microarray analysis [PDF]
Frontiers in Oncology, 2023 BackgroundThis study aimed to explore the potential effects of long non-coding RNAs (lncRNAs) in multiple myeloma (MM) patients using two detection methods: high-throughput sequencing and microarray.MethodsIn this study, lncRNAs were detected in 20 newly
Min-Qiu Lu +7 more
doaj +3 more sources