Results 11 to 20 of about 2,947 (208)

MiR-618 suppresses the proliferation, invasion, and migration of non-small lung cancer via the JAK2/STAT3 axis [PDF]

Journal of Cardiothoracic Surgery
Objective The regulatory role of the miR-618/JAK2/STAT3 axis in non-small cell lung cancer cells (NSCLC) was investigated with the objective of identifying a target for the precise treatment of patients with NSCLC.
Ziyuan Chen, Wei Chen, Zhiqi Hong, Xianqiao Wu, Tianzheng Fang, Yufei Sheng, Shuai Fang, Chengwei Zhou   +7 more
doaj   +4 more sources

rs2682818/MiR-618 is a novel marker associated with increased risk of breast cancer in the Iranian population [PDF]

Archives of Biological Sciences, 2021
The presence of single nucleotide variations in the coding region of micro-RNA (miRNA)-encoding genes plays a significant role in the expression and function of these molecules in oncogenesis and cancer.
Najafian-Najafabady Atefeh, Ebrahimi Nasim, Vallian Sadeq   +2 more
doaj   +3 more sources

Promising Candidate Urinary MicroRNA Biomarkers for the Early Detection of Hepatocellular Carcinoma among High-Risk Hepatitis C Virus Egyptian Patients [PDF]

Journal of Cancer, 2012
MicroRNAs (miRNA) are small endogenously expressed non-coding RNAs that negatively regulate expression of protein-coding genes at the translational level. Accumulating evidence, such as aberrant expression of miRNAs, suggests that they play a role in the
Moemen AK Abdalla, Yousef Haj-Ahmad
doaj   +2 more sources

Key genes associated with brain metastasis in non-small cell lung cancer: novel insights from bioinformatics analysis [PDF]

Frontiers in Bioinformatics
BackgroundThis study aims to investigate potential biomarkers associated with NSCLC-BM and elucidate their regulatory roles in critical pathways involved in cerebral metastatic dissemination.MethodsThe identified DEGs were subjected to functional ...
Shuang Zhao, He Zhang
doaj   +2 more sources

Circulating extracellular vesicles as potential biomarkers and mediators of acute respiratory distress syndrome in sepsis [PDF]

Scientific Reports
The early sequence of respiratory failure events after the onset of sepsis is still unknown. We hypothesize that the lung should signal through circulating extracellular vesicles (EVs) when it is affected by a systemic inflammatory response.
Marcelo Fernando do Nascimento, Ludmila Rodrigues Pinto Ferreira, José Mauro Vieira Junior, Daniel Deheinzelin, Ana Cláudia Aparecida Santos Nussbaum, Luis Henrique Toshihiro Sakamoto, Renata Ottes Vasconcelos, Reinaldo Salomao, Jaques Waisberg, Luciano Cesar Pontes Azevedo, Roger Chammas, Juliana Monte Real   +11 more
doaj   +2 more sources

Placental whole transcriptome expression profile in patients with early-onset, late-onset preeclampsia and gestational diabetes mellitus [PDF]

Scientific Reports
Preeclampsia (PE) and gestational diabetes mellitus (GDM) are significant pregnancy complications with complex pathogenesis. Therefore, we conducted a comprehensive investigation using whole-transcriptome sequencing of placental samples.
Zhuo Chen, Li Yang, Li Geng, Xinwen Zhang, Mingyu Du, Yonghu Sun, Lin Zhao, Bing Bai, Xiaohong Li   +8 more
doaj   +2 more sources

miR-618 rs2682818 C>A polymorphism decreases Hirschsprung disease risk in Chinese children. [PDF]

Biosci Rep, 2020
Abstract MicroRNAs (miRNAs) are endogenous non-coding small RNAs that play an important role in the development of many malignant tumors. In addition, recent studies have reported that single nucleotide polymorphisms (SNPs) located in the miRNA functional region was inextricably linked to tumor susceptibility.
Zheng Y, Lu T, Xie X, He Q, Lu L, Zhong W.   +5 more
europepmc   +4 more sources

Targetome profiling and functional genetics implicate miR-618 in lymphomagenesis. [PDF]

Epigenetics, 2014
Despite the voluminous body of observational evidence concerning the role of miRNAs in cancer, significant knowledge gaps remain concerning the molecular circumstances that underlie the miRNA-cancer connection. In this study, we employ a multidisciplinary approach to establish an association between miR-618 and non-Hodgkin lymphoma (NHL) in a human ...
Fu A, Hoffman AE, Liu R, Jacobs DI, Zheng T, Zhu Y.   +5 more
europepmc   +5 more sources

miR-618 Inhibits Prostate Cancer Migration and Invasion by Targeting FOXP2. [PDF]

J Cancer, 2017
miRNAs play critical role in the development and progression of prostate cancer. Here we studied the role of miR-618 in prostate cancer migration and invasion. miR-618 was downregulated in metastatic androgen-independent prostate cancer (AIPC), patients with low miR-618 had poor outcome.
Song XL, Tang Y, Lei XH, Zhao SC, Wu ZQ.
europepmc   +4 more sources

Does miR-618 rs2682818 variant affect cancer susceptibility? Evidence from 10 case-control studies. [PDF]

Biosci Rep, 2019
Abstract Piles of evidence have supported the relationship between miR-618 rs2682818 polymorphism and tumorigenesis, but the conclusion remains inconsistent. In the present study, we conducted a meta-analysis to sniff out the potential risk between miR-618 rs2682818 and overall cancers.
Feng X, Ji D, Liang C, Fan S.
europepmc   +4 more sources