Journal of Food Biochemistry, 2022 Tanshinone IIA (TAN) is widely employed for handling cardiovascular disorders. The current study explored the potential role of miRs in the antifibrotic effect of TAN on heart. Fibrotic features were induced in cardiac fibroblasts (CFs) and in rat hearts,
Na Yan +4 more
semanticscholar +3 more sources
Promising Candidate Urinary MicroRNA Biomarkers for the Early Detection of Hepatocellular Carcinoma among High-Risk Hepatitis C Virus Egyptian Patients [PDF]
Journal of Cancer, 2012 MicroRNAs (miRNA) are small endogenously expressed non-coding RNAs that negatively regulate expression of protein-coding genes at the translational level. Accumulating evidence, such as aberrant expression of miRNAs, suggests that they play a role in the
Moemen AK Abdalla, Yousef Haj-Ahmad
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Differential expression of miR-145 in children with Kawasaki disease. [PDF]
PLoS ONE, 2013 Kawasaki disease is an acute, self-limited vasculitis of childhood that can result in structural damage to the coronary arteries. Previous studies have implicated the TGF-β pathway in disease pathogenesis and generation of myofibroblasts in the arterial ...
Chisato Shimizu +10 more
doaj +2 more sources
Key genes associated with brain metastasis in non-small cell lung cancer: novel insights from bioinformatics analysis [PDF]
Frontiers in BioinformaticsBackgroundThis study aims to investigate potential biomarkers associated with NSCLC-BM and elucidate their regulatory roles in critical pathways involved in cerebral metastatic dissemination.MethodsThe identified DEGs were subjected to functional ...
Shuang Zhao, He Zhang
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Placental whole transcriptome expression profile in patients with early-onset, late-onset preeclampsia and gestational diabetes mellitus [PDF]
Scientific ReportsPreeclampsia (PE) and gestational diabetes mellitus (GDM) are significant pregnancy complications with complex pathogenesis. Therefore, we conducted a comprehensive investigation using whole-transcriptome sequencing of placental samples.
Zhuo Chen +8 more
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67P Evaluation of genetic variants in miR-146-a, miR-618, and miR-181b as risk factors of colorectal cancer in Bulgarian patients [PDF]
Annals of Oncology, 2020 M. Radanova +8 more
semanticscholar +2 more sources
Dexmedetomidine alleviates diabetic neuropathic pain by inhibiting microglial activation via regulation of miR618/P2Y12 pathway [PDF]
, 2021 Purpose: To investigate the effect of dexmedetomidine on streptozotocin (STZ)-induced diabetic neuropathy pain (DNP) in rats and elucidate its mechanism of action.Methods: The DNP rat model was established by injecting STZ (70 mg/kg) following ...
Cong, Shan, Qiao2, Yan, Song, Jiannan
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Frontiers in Psychiatry, 2021 Competing endogenous RNA (ceRNA) and autophagy were related to neurological diseases. But the relationship among ceRNA, autophagy and Schizophrenia (SZ) was not clear. In this study, we obtained gene expression profile of SZ patients (GSE38484, GSE54578,
Rongjie Li +15 more
doaj +1 more source
Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis [PDF]
, 2017 Objective. Plasmacytoid dendritic cells (PDCs) are a critical source of type I interferons (IFNs) that can contribute to the onset and maintenance of autoimmunity.
Affandi, Alsya J +21 more
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