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miR-770-5p regulates EMT and invasion in TNBC cells by targeting DNMT3A
Cellular Signalling, 2021MicroRNAs (miRNAs) are shown to regulate various processes in cancer like motility and invasion that are key features of the metastatic triple negative breast cancer (TNBCs). Epithelial-mesenchymal transition (EMT) is one of the well-defined cellular transitioning processes characterized with reduced E-cadherin expression and increased mesenchymal ...
Senem, Noyan +3 more
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Acta Diabetologica, 2022
Diabetes nephropathy (DN) is one of the major complications in diabetes. With the improvement of people's living standards in China in recent years, the incidence of diabetes has become the main cause of end-stage renal disease. However, how and whether circ ASAP2 could mediate DN remain poorly understood. This study aimed to determine the function and
Qin Li, Xiangjian Meng, Qiang Hua
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Diabetes nephropathy (DN) is one of the major complications in diabetes. With the improvement of people's living standards in China in recent years, the incidence of diabetes has become the main cause of end-stage renal disease. However, how and whether circ ASAP2 could mediate DN remain poorly understood. This study aimed to determine the function and
Qin Li, Xiangjian Meng, Qiang Hua
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Brain Research, 2021
Circular RNAs (circRNAs) are found to regulate glioblastoma evolution. However, the role of circ-ATP binding cassette subfamily C member 3 (circABCC3) in glioblastoma process is still unknown. In this study, the effects of circABCC3 on glioblastoma tumorigenesis and underlying mechanism were revealed.The expression levels of circABCC3, microRNA-770-5p (
Huan, Zhang, Wei, Xu
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Circular RNAs (circRNAs) are found to regulate glioblastoma evolution. However, the role of circ-ATP binding cassette subfamily C member 3 (circABCC3) in glioblastoma process is still unknown. In this study, the effects of circABCC3 on glioblastoma tumorigenesis and underlying mechanism were revealed.The expression levels of circABCC3, microRNA-770-5p (
Huan, Zhang, Wei, Xu
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Molecular Biology Reports, 2021
Microvascular complications related to diabetes mellitus type II such as foot ulcers are the reason of many mortalities among T2DM patients. The role of microRNAs (miRNAs, miRs) as potent regulators of gene expression is studied in different diseases such as diabetes mellitus and primary studies revealed their importance as early detecting biomarkers ...
Rashin VatanIman +3 more
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Microvascular complications related to diabetes mellitus type II such as foot ulcers are the reason of many mortalities among T2DM patients. The role of microRNAs (miRNAs, miRs) as potent regulators of gene expression is studied in different diseases such as diabetes mellitus and primary studies revealed their importance as early detecting biomarkers ...
Rashin VatanIman +3 more
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miR-770-5p: A novel molecular target regulating KLF4/EGFR signaling through PRMT5 interaction
Medical OncologyTNBC represents an exceptionally aggressive subtype, distinguished by the absence of targeted therapeutic options. miR-770-5p, a tumor suppressor microRNA, has been shown to regulate critical cancer-associated signaling pathways. PRMT5, is frequently overexpressed in various malignancies and plays a pivotal role in regulating cellular processes ...
Senem Noyan +3 more
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Drug Resistance Updates
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease. Chemotherapy based on gemcitabine (GEM) remains the first-line drug for patients with advanced PDAC. However, GEM resistance impairs its therapeutic effectiveness. Therefore, identifying effective therapeutic targets are urgently needed to overcome GEM resistance.The clinical ...
Wenjie, Huang +9 more
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Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease. Chemotherapy based on gemcitabine (GEM) remains the first-line drug for patients with advanced PDAC. However, GEM resistance impairs its therapeutic effectiveness. Therefore, identifying effective therapeutic targets are urgently needed to overcome GEM resistance.The clinical ...
Wenjie, Huang +9 more
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Biochemical Genetics
A series of studies have confirmed the relationship between circular RNAs (circRNAs) and metabolic diseases. Hsa_circ_0006260 has been reported to be lowly expressed in the placenta of gestational diabetes mellitus (GDM) patients, but the underlying mechanism and its biological functions remain obscure. Placental tissues were collected from 37 pregnant
Wei, Liu +3 more
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A series of studies have confirmed the relationship between circular RNAs (circRNAs) and metabolic diseases. Hsa_circ_0006260 has been reported to be lowly expressed in the placenta of gestational diabetes mellitus (GDM) patients, but the underlying mechanism and its biological functions remain obscure. Placental tissues were collected from 37 pregnant
Wei, Liu +3 more
openaire +2 more sources
Molecular Biology Reports
Cancer cells employ various adaptive mechanisms to withstand stressors, with one notable pathway being the unfolded protein response (UPR), crucial in fostering endocrine resistance within ER-positive breast cancer. Investigating miRNAs within tumors holds promise for identifying key miRNA-gene interactions pivotal for tumor characteristics like ...
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Cancer cells employ various adaptive mechanisms to withstand stressors, with one notable pathway being the unfolded protein response (UPR), crucial in fostering endocrine resistance within ER-positive breast cancer. Investigating miRNAs within tumors holds promise for identifying key miRNA-gene interactions pivotal for tumor characteristics like ...
openaire +2 more sources