Results 21 to 30 of about 1,193 (207)
The Use of Plant Macrofossils for Paleoenvironmental Reconstructions in Southern European Peatlands
Quaternary, 2019 The analysis of plant macrofossils in peatland ecosystems has been widely used for the climatic and ecological reconstruction of the Holocene in the high latitudes of the northern hemisphere.
Martin Souto +3 more
doaj +1 more source
A new Neoplatyura Malloch from Finland (Diptera, Keroplatidae)
Biodiversity Data Journal, 2014 The genus Neoplatyura Malloch is globally represented by 50 species, of which four are European species. In this article a new European Neoplatyura from Finland is described. The new species, Neoplatyura noorae Salmela, sp. n.
Jukka Salmela, Anna Suuronen
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Diversity, 2022 Paleoecological reconstructions of hydrological regimes in tropical peatlands during the Holocene are important for the estimation of their responses to changing environments. However, the application of some widely used proxies, such as testate amoebae,
Andrey N. Tsyganov +7 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem +17 more
wiley +1 more source
Methods for determining peat humification and for quantifying peat bulk density, organic matter and carbon content for palaeostudies of climate and peatland carbon dynamics [PDF]
Mires and Peat, 2011 Quantitative palaeostudies of climate change and carbon dynamics are reliant on precise and accurate laboratory measurements. Here we present laboratory protocols for the colorimetric determination of peat humification and for bulk density and organic ...
F.M. Chambers, D.W. Beilman, Z. Yu
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak +4 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller +14 more
wiley +1 more source