Results 271 to 280 of about 461,417 (302)
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miRNAs Targeting and Targeting miRNAs
2009With the recent advance of research into microRNAs (miRNAs), this category of endogenous noncoding small ribonucleic acids (19–25 nts in length) has rapidly emerged as one of the central regulators of expression of an extensive repertoire of genes. MiRNAs are an abundant RNA species constituting >2% of the predicted human genes (> 1,000 genes), which ...
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Science, 2017
Small RNA Decay Although much work has examined microRNA (miRNA) biogenesis, relatively little is known about miRNA decay. Elbarbary et al. now identify Tudor-SN, an endonuclease that interacts with the RNA-induced silencing complex. Tudor-SN targets miRNAs at CA and UA dinucleotides located more than five nucleotides from miRNA ends. Tudor–SN-mediated
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Small RNA Decay Although much work has examined microRNA (miRNA) biogenesis, relatively little is known about miRNA decay. Elbarbary et al. now identify Tudor-SN, an endonuclease that interacts with the RNA-induced silencing complex. Tudor-SN targets miRNAs at CA and UA dinucleotides located more than five nucleotides from miRNA ends. Tudor–SN-mediated
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Life Sciences, 2011
Despite significant advances in treatments, cardiovascular disease (CVD) remains the leading cause of human morbidity and mortality in developed countries. The development of novel and efficient treatment strategies requires an understanding of the basic molecular mechanisms underlying cardiac function.
Terry S, Elton +5 more
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Despite significant advances in treatments, cardiovascular disease (CVD) remains the leading cause of human morbidity and mortality in developed countries. The development of novel and efficient treatment strategies requires an understanding of the basic molecular mechanisms underlying cardiac function.
Terry S, Elton +5 more
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Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011
The Epstein-Barr virus (EBV) is an oncogenic Herpes virus involved in the induction of a variety of human tumours. It was the first virus found to encode microRNAs (miRNAs). MiRNAs are short, non-coding RNAs that in most cases negatively regulate gene expression at the post-transcriptional level.
Stephanie, Barth +2 more
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The Epstein-Barr virus (EBV) is an oncogenic Herpes virus involved in the induction of a variety of human tumours. It was the first virus found to encode microRNAs (miRNAs). MiRNAs are short, non-coding RNAs that in most cases negatively regulate gene expression at the post-transcriptional level.
Stephanie, Barth +2 more
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NTP4 modulates miRNA accumulation via asymmetric modification of miRNA/miRNA* duplex
Science China Life Sciences, 2020Wenwen, Kong +7 more
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Structure of the human DICER–pre-miRNA complex in a dicing state
Nature, 2023, Hansol Lee, Haedong Kim
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MicroRNA-mediated regulation of glucose and lipid metabolism
Nature Reviews Molecular Cell Biology, 2021Richard W Carthew
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Regulation of microRNA biogenesis
Nature Reviews Molecular Cell Biology, 2014Minju Ha, Vic Narry Kim
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Identification and consequences of miRNA–target interactions — beyond repression of gene expression
Nature Reviews Genetics, 2014Jean Hausser, Mihaela Zavolan
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MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
Nature Reviews Drug Discovery, 2017Rajesha Rupaimoole, Frank J Slack
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