Results 1 to 10 of about 162,392 (281)

Impact of sitagliptin on endometrial mesenchymal stem-like progenitor cells: A randomised, double-blind placebo-controlled feasibility trial [PDF]

EBioMedicine, 2020
Background: Recurrent pregnancy loss (RPL) is associated with the loss of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment of bone marrow-derived cells to sites of tissue injury.
Shreeya Tewary, Emma S. Lucas, Risa Fujihara, Peter K. Kimani, Angela Polanco, Paul J. Brighton, Joanne Muter, Katherine J. Fishwick, Maria José Minhoto Diniz Da Costa, Lauren J. Ewington, Lauren Lacey, Satoru Takeda, Jan J. Brosens, Siobhan Quenby   +13 more
doaj   +3 more sources

Miscarriage syndrome: Linking early pregnancy loss to obstetric and age-related disorders

EBioMedicine, 2022
Summary: Upon embryo implantation, the uterine mucosa - the endometrium - transforms into a robust decidual matrix that accommodates the fetal placenta throughout pregnancy. This transition is driven by the differentiation of endometrial fibroblasts into
Pietro Bortoletto, Emma S. Lucas, Pedro Melo, Ioannis D. Gallos, Adam J. Devall, Tom Bourne, Siobhan Quenby, Phillip R. Bennett, Arri Coomarasamy, Jan J. Brosens   +9 more
doaj   +1 more source

Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation

BMC Medicine, 2022
Background Emerging evidence supports an association between vaginal microbiota composition and risk of miscarriage; however, the underlying mechanisms are poorly understood.
Karen Grewal, Yun S. Lee, Ann Smith, Jan J. Brosens, Tom Bourne, Maya Al-Memar, Samit Kundu, David A. MacIntyre, Phillip R. Bennett   +8 more
doaj   +1 more source

Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos [PDF]

, 2012
Background The aetiology of recurrent miscarriage (RM) remains largely unexplained. Women with RM have a shorter time to pregnancy interval than normally fertile women, which may be due to more frequent implantation of non-viable embryos.
AJ Wilcox, AM Musters, Annemieke Kavelaars, B Gellersen, Birgit Gellersen, Charlotte H. E. Weimar, Cobi J. Heijnen, Cornelis B. Lambalk, CW Redman, DK Gardner, E Vanneste, EB Baart, G Teklenburg, G Teklenburg, GM Stirrat, H Carp, HJ Leese, HJ Leese, HM Picton, IC Lakovschek, Jan J. Brosens, JD Aplin, JL Evers, Johanna M. T. de Vreeden-Elbertse, M Bielanska, M Gonzalez, M Salker, N Mansouri-Attia, Nick S. Macklon, NS Macklon, PJ Stokes, R Rai, RM Popovici, S Grewal, S Grewal, S Quenby   +35 more
core   +15 more sources

Chromosomal polymorphisms in assisted reproduction: an analysis of 942 cycles

Vascular Biology, 2022
The use of intracytoplasmic sperm injection (ICSI) has recently increased worldwide. The live birth rate per ICSI cycle is low, and over half of infertile couples remain childless.
Madara S B Ralapanawe, Sugandika Lakmali Gajaweera, Nishendra Karunaratne, Malcolm James Price, Pedro Melo, Arri Coomarasamy, Ioannis Gallos   +6 more
doaj   +1 more source

A comprehensive analysis of chromosomal polymorphic variants on reproductive outcomes after intracytoplasmic sperm injection treatment

Scientific Reports, 2023
Recent studies suggest that chromosomal polymorphic variations are associated with infertility. A systematic review of chromosomal polymorphisms in assisted reproduction found an association with higher rates of miscarriage.
Madara S. B. Ralapanawe, Sugandika L. Gajaweera, Nishendra Karunaratne, Vajira H. W. Dissanayake, Malcolm J. Price, Pedro Melo, Arri Coomarasamy, Ioannis D. Gallos   +7 more
doaj   +1 more source

Experiences of young girls and women undergoing ovarian tissue cryopreservation: a systematic review and thematic synthesis

Journal of Psychosomatic Obstetrics and Gynecology, 2022
The aim of this study was to explore the experiences of young girls and women who underwent or considered ovarian tissue cryopreservation (OTC) using a systematic review of qualitative studies with thematic synthesis framework. Major electronic databases:
Hajra Khattak, Hannah Woodman, Yousri Afifi, Christiani A. Amorim, Simon Fishel, Ioannis Gallos, Arri Coomarasamy, Annie Topping   +7 more
doaj   +1 more source

The Role of Decidual Subpopulations in Implantation, Menstruation and Miscarriage

Frontiers in Reproductive Health, 2021
In each menstrual cycle, the endometrium becomes receptive to embryo implantation while preparing for tissue breakdown and repair. Both pregnancy and menstruation are dependent on spontaneous decidualization of endometrial stromal cells, a progesterone ...
Joanne Muter, Joanne Muter, Chow-Seng Kong, Jan J. Brosens, Jan J. Brosens   +4 more
doaj   +1 more source

Sporadic pregnancy loss and recurrent miscarriage

Репродуктивная эндокринология, 2020
Progesterone is essential for the maintenance of pregnancy, and progesterone deficiency is associated with miscarriage. The subject of whether progesterone supplementation in early pregnancy can prevent miscarriage has been a long-standing research ...
A. Coomarasamy, A. J. Devall
doaj   +1 more source

Evaluating cut‐off levels for progesterone, β human chorionic gonadotropin and β human chorionic gonadotropin ratio to exclude pregnancy viability in women with a pregnancy of unknown location: A prospective multicenter cohort study

Acta Obstetricia et Gynecologica Scandinavica, 2022
Introduction There is no global agreement on how to best determine pregnancy of unknown location viability and location using biomarkers. Measurements of progesterone and β human chorionic gonadotropin (βhCG) are still used in clinical practice to ...
Shabnam Bobdiwala, Christopher Kyriacou, Evangelia Christodoulou, Jessica Farren, Nicola Mitchell‐Jones, Maya Al‐Memar, Francis Ayim, Baljinder Chohan, Emma Kirk, Osama Abughazza, Bramara Guruwadahyarhalli, Sharmistha Guha, Veluppillai Vathanan, Debbie Gould, Catriona Stalder, Dirk Timmerman, Ben Van Calster, Tom Bourne   +17 more
doaj   +1 more source