Results 41 to 50 of about 97,151 (249)

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

The experiences of men following recurrent miscarriage in an Irish tertiary hospital: A qualitative analysis

Health Expectations, 2022
Introduction Miscarriage is one of the most common complications of pregnancy, and recurrent miscarriage affects approximately 1% of couples. The psychological impact of early pregnancy loss on women has been well documented in the literature; however ...
Tommy Harty, Maria Trench, Orla Keegan, Keelin O'Donoghue, Daniel Nuzum   +4 more
doaj   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Decreased Ovarian Reserve Predicts Inexplicability of Recurrent Miscarriage? A Retrospective Analysis. [PDF]

PLoS ONE, 2016
OBJECTIVE:To evaluate anti-Mullerian hormone, basal follicle stimulating hormone, luteinizing hormone, estradiol, and female age in women with recurrent miscarriage and to compare women with explained and idiopathic recurrent miscarriage.
Sophie Pils, Regina Promberger, Stephanie Springer, Elmar Joura, Johannes Ott   +4 more
doaj   +1 more source

The Association between Some Demographic Characteristics and the Types of Miscarriage among Women in Rania City

Kufa Journal for Nursing Sciences, 2023
Background: Miscarriage or spontaneous abortion is one of the prevalent adverse reproductive outcomes, which seriously threatens maternal health around the world.
Sharmin Abdalrahman Kareem, Sanna Hassan Abdulsahib   +1 more
doaj   +1 more source

Miscarriage, stillbirth and congenital malformation in the offspring of UK veterans of the first Gulf war.

, 2004
OBJECTIVES: To assess whether the offspring of UK veterans of the first Gulf war are at increased risk of fetal death or congenital malformation. METHOD: This was a retrospective reproductive cohort study of UK Gulf war veterans and a demographically ...
Prior, Susan, Maconochie, Noreen, Pelerin, Margo, Lewis, Samantha, Doyle, Pat, Maconochie, Ian, Davies, Graham   +6 more
core   +1 more source

The National Women's Health Study: assembly and description of a population-based reproductive cohort. [PDF]

, 2004
BACKGROUND: Miscarriage is a common event but is remarkably difficult to measure in epidemiological studies. Few large-scale population-based studies have been conducted in the UK.
Prior, Susan, Susan Prior, Maconochie, Noreen, Noreen Maconochie, Doyle, Pat, Pat Doyle, Prior Susan, Doyle Pat, Maconochie Noreen   +8 more
core   +2 more sources

Distribution of demographic characteristics by post-miscarriage health problems following a miscarriage (N = 1843).

, 2023
Distribution of demographic characteristics by post-miscarriage health problems following a miscarriage (N = 1843).
Samuel Kwaku Essien (4473853), Batholomew Chireh (7045436), Peter Kwabena Essien (17118007)   +2 more
core   +1 more source