Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Systematic review of prophylactic antibacterial agents for radiation-induced oral mucositis in head and neck cancer. [PDF]
Alicea DS +8 more
europepmc +1 more source
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Editorial: Endocrine insights into heart disease. [PDF]
Júnior RFR +3 more
europepmc +1 more source
Frequencies and causes of pre-analytical errors in a tertiary care hospital laboratory in Saudi Arabia. [PDF]
Alenezy NT +6 more
europepmc +1 more source
Efficacy and safety of proton therapy and photon therapy for patients with craniopharyngioma: a systematic review and meta‑analysis. [PDF]
Pan LS +5 more
europepmc +1 more source
An Investigation Into Contaminated Waste Composition in a University Dental Clinic: Opportunities for Sustainability in Dentistry. [PDF]
Yeoh S +6 more
europepmc +1 more source
Drug development in psoriatic arthritis: a trialtrove-based landscape analysis (1999-2025). [PDF]
Wang G +8 more
europepmc +1 more source

