Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy +7 more
wiley +2 more sources
Endogenous targets of Zuo1-mediated mRNA surveillance encode proteins with higher predicted disorder. [PDF]
iScienceChang S, Coller J.
europepmc +1 more source
The Plant Journal, Volume 128, Issue 3, November 2026.SUMMARY Plant metabolism drives traits essential for productivity and resilience, yet understanding metabolic networks requires subcellular, cellular, and tissue‐level spatial context that remains limited, particularly in crop species. Experimentally derived subcellular localization data for enzymes are sparse, constraining analyses of metabolic ...
Purva Karia +10 more
wiley +1 more source
Dimerization of natively folded molecules drives misfolding and aggregation in Cys-depleted variants of cataract-associated human lens γD-crystallin. [PDF]
J Biol ChemPu Y +4 more
europepmc +1 more source
A Portal‐Preorganized Cucurbit[7]uril‐Ruthenium Conjugate Enables Motif‐Selective Protein Sensing
Angewandte Chemie International Edition, Volume 65, Issue 44, 26 October 2026.Reprogramming cucurbit[7]uril (CB7) recognition through portal engineering transforms an optically silent host into a motif‐selective photoluminescent receptor. The portal‐preorganized CB7‐Rubpy conjugate directly reports changes in aromatic motif accessibility, enabling optical sensing of protein misfolding and refolding.
Patrick Gruhs +10 more
wiley +1 more source
Failure of Hepatic Insulin Clearance via CEACAM1-Mediated Endocytosis: The Missing Physiological Link Between Proinsulin Misfolding, Hyperinsulinemia, and Metabolic Complications in Type 2 Diabetes, Obesity, and NAFLD. [PDF]
Probl Endokrinol (Mosk)Akl MM, Ahmed A.
europepmc +1 more source
AI-driven insights into protein misfolding and innate immunity in neurodegenerative diseases. [PDF]
Front ImmunolDeng HX +6 more
europepmc +1 more source
Targeted Protein Modification with an Antibody-Based System
ACS Central ScienceOded Rimon +7 more
doaj +1 more source
Scalable assay to identify inhibitors of prion-like propagation of protein misfolding as potential therapeutics for neurodegeneration. [PDF]
Protein SciNarayan A, Neupane K, Woodside MT.
europepmc +1 more source
An Immuno-Infrared Sensor Detects Preclinical Alzheimer's and Parkinson's Disease by Protein Misfolding. [PDF]
J Phys Chem BGerwert G +15 more
europepmc +1 more source