ChemMedChem, Volume 21, Issue 21, 12 November 2026.Can a single element help address the multifactorial nature of ALS? Boron‐containing compounds combine responsiveness to reactive oxygen species (ROS), neuroprotective activity, and favorable pharmacological properties, offering a distinctive framework for disease modification in a complex disease like ALS.
Nitesh Sanghai +5 more
wiley +1 more source
Do Extracellular Vesicles and the Biochemical Microenvironment Contribute to Amyloid Transthyretin Cardiomyopathy? [PDF]
JACC AdvFranzini M, Greco F, Musetti V, Emdin M.
europepmc +1 more source
All‐Amyloid Functional Coacervates
Advanced Materials, Volume 38, Issue 61, 2 November 2026.This study introduces an all‐amyloid interfacial complex coacervate technique that employs charge‐mediated or functionalization‐assisted complexation of oppositely charged food protein‐derived amyloid nanofibrils to engineer functional soft constructs across multiple length scales.
Seyyed Alireza Hashemi +4 more
wiley +1 more source
Complete SLC4A11 Detection in Saudi Congenital Hereditary Endothelial Dystrophy: A Transmembrane Glycine Hotspot and a Recurrent Splice Donor Allele in Consanguineous Patients. [PDF]
Int J Mol SciAbu-Amero KK +3 more
europepmc +1 more source
Annals of Neurology, Volume 100, Issue 5, Page 1055-1067, November 2026.Objective To characterize magnetic resonance imaging (MRI)‐based glymphatic surrogates in Huntington's disease (HD) using MRI measures of perivascular diffusivity and structural perivascular alterations across multiple large cohorts. Methods We analyzed 2,731 MRI sessions from 880 participants across 3 large retrospective HD cohorts.
Alexia Solomon +5 more
wiley +1 more source
The Sulfate-Reducing Bacteria Hypothesis in Parkinson's Disease: From <i>Desulfovibrio</i>-Derived Hydrogen Sulfide to Alpha-Synuclein Aggregation. [PDF]
BiomedicinesKoterba M +6 more
europepmc +1 more source
Revisiting Inherited Metabolic Diseases (IMDs) Through the Lens of Selective Autophagy
Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.ABSTRACT Selective autophagy is increasingly recognized as a fundamental quality‐control mechanism that complements bulk autophagy by enabling the targeted degradation of specific intracellular cargos, including mitochondria, endoplasmic reticulum (ER), lipid droplets, glycogen, peroxisomes, ferritin, ribosomes, and protein aggregates.
Marianna Maddaluno +3 more
wiley +1 more source
Proteostasis breakdown and aggregate diversity in aging and neurodegenerative disease. [PDF]
Front Aging NeurosciKhan ZN.
europepmc +1 more source
MedComm, Volume 7, Issue 11, November 2026.Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He +4 more
wiley +1 more source
Editorial: Unraveling protein misfolding and innate immunity in neurodegenerative diseases. [PDF]
Front ImmunolFang Q, Hong Y, Zhu B.
europepmc +1 more source