Results 101 to 110 of about 95,914 (208)

Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates

Communications Chemistry
Protein condensates can exist in different states with distinct material properties, corresponding to specific cellular functions. These material properties, however, remain difficult to characterise, in part due to the technical challenges associated ...
Alyssa Miller, Zenon Toprakcioglu, Seema Qamar, Peter St George-Hyslop, Francesco Simone Ruggeri, Tuomas P. J. Knowles, Michele Vendruscolo   +6 more
doaj   +1 more source

Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]

, 2018
The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core   +1 more source

Protein Misfolding Diseases [PDF]

Future Science OA, 2015
openaire   +2 more sources

“Prion-like” seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders

Frontiers in Neuroscience
Intra- or extracellular aggregates of proteins are central pathogenic features in most neurodegenerative disorders. The accumulation of such proteins in diseased brains is believed to be the end-stage of a stepwise aggregation of misfolded monomers to ...
Silvia Zampar, Silvia Zampar, Sonja E. Di Gregorio, Sonja E. Di Gregorio, Gustavo Grimmer, Gustavo Grimmer, Joel C. Watts, Joel C. Watts, Martin Ingelsson, Martin Ingelsson, Martin Ingelsson, Martin Ingelsson, Martin Ingelsson   +12 more
doaj   +1 more source

Impaired Acetyl-CoA Compartmentalization Drives a Futile Lipogenic–Oxidative Cycle in N88S Seipinopathy

Cells
The N88S mutation in human seipin causes a dominant motor neuron disease marked by ER stress and inclusion body formation, lipid imbalance, and oxidative damage.
Vítor Moreira, Carlo W. T. van Roermund, Vítor Costa, Vitor Teixeira   +3 more
doaj   +1 more source

Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification

ACS Central Science, 2019
Philip R. Lindstedt, Francesco A. Aprile, Maria J. Matos, Michele Perni, Jean B. Bertoldo, Barbara Bernardim, Quentin Peter, Gonzalo Jiménez-Osés, Tuomas P. J. Knowles, Christopher M. Dobson, Francisco Corzana, Michele Vendruscolo, Gonçalo J. L. Bernardes   +12 more
doaj   +1 more source

Mutations of Gly277 in <i>CPA1</i>-related chronic pancreatitis: clinical clues for misfolding aetiology. [PDF]

Gut
Zheng Y, Scheers I, Sándor M, Yi G, Sahin-Tóth M.   +4 more
europepmc   +1 more source

Adjacent domains drive the emergence of misfolded intermediates in the folding pathway of the PDZ4 from MAGI1. [PDF]

BBA Adv
Pennacchietti V, Obreja CM, Marinidis D, Di Matteo S, Ippoliti R, Gianni S, Malagrinò F.   +6 more
europepmc   +1 more source

A widespread protein misfolding mechanism is differentially rescued in vitro by chaperones based on gene essentiality. [PDF]

Nat Commun
Sitarik I, Vu QV, Petucci J, Frutos P, Song H, O'Brien EP.   +5 more
europepmc   +1 more source

Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core. [PDF]

J Phys Chem Lett
Nadwa H, Brotzakis ZF, Santucci A, Braconi D, Vendruscolo M.   +4 more
europepmc   +1 more source