Results 91 to 100 of about 95,914 (208)
GroEL dependency affects codon usage—support for a critical role of misfolding in gene evolution
Molecular Systems Biology, 2010 It has recently been suggested that the use of optimal codons limits mistranslation‐induced protein misfolding, yet evidence for this remains largely circumstantial.
Tobias Warnecke, Laurence D Hurst
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Biophysical Characterization of α-Synuclein and Rotenone Interaction
Biomolecules, 2013 Previous studies revealed that pesticides interact with α-synuclein and accelerate the rate of fibrillation. These results are consistent with the prevailing hypothesis that the direct interaction of α-synuclein with pesticides is one of many suspected ...
Anthony L. Fink +3 more
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Error-proof programmable self-assembly of DNA-nanoparticle clusters
, 2007 We study theoretically a new generic scheme of programmable self-assembly of nanoparticles into clusters of desired geometry. The problem is motivated by the feasibility of highly selective DNA-mediated interactions between colloidal particles.
A. Y. Grosberg +4 more
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Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]
, 2015 The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia +2 more
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The VES hypothesis and protein misfolding
Discrete and Continuous Dynamical Systems - S, 2011 Proteins function by changing conformation. These conformational changes, which involve the concerted motion of a large number of atoms are classical events but, in many cases, the triggers are quantum mechanical events such as chemical reactions. Here the initial quantum states after the chemical reaction are assumed to be vibrational excited states ...
openaire +2 more sources
Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response. [PDF]
, 2015 Protein misfolding neurodegenerative diseases arise through neurotoxicity induced by aggregation of host proteins. These conditions include Alzheimer's disease, Huntington's disease, Parkinson's disease, motor neuron disease, tauopathies and prion ...
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mAbsMost immune-system created antibodies balance good binding and stability with low toxicity and self-reactivity. Quantifying the nativeness of a candidate sequence – its likelihood of belonging to natural immune repertoires – has thus emerged as a ...
Aubin Ramon +6 more
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Exploring the Molecular Pathology of Iatrogenic Amyloidosis
Journal of Molecular PathologyIatrogenic amyloidosis results from medical therapeutic interventions, leading to the misfolding and aggregation of proteins into amyloid fibrils or to their direct deposition in different tissues.
Bernardo Bonilauri
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