Results 111 to 120 of about 25,182 (194)
Abstract Neurons depend on tightly regulated spatial proteostasis to maintain function across their extended morphology. The endoplasmic reticulum (ER), traditionally known for its function in protein synthesis, folding, and trafficking, has long been recognized as a central platform for directing proteins to organelles of the secretory and endocytic ...
J. Tabitha Hees, Angelika B. Harbauer
wiley +1 more source
The fluorescence intensity as well as the spectral shape of the emission of single dye molecules strongly depend on the molecules’ exact position relative to plasmonic nanoparticles in hybrid systems. By point‐spread function modification analysis, the vertical binding location of single fluorophores on gold nanocones is obtained and correlated to both
Lukas Lang +6 more
wiley +1 more source
Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari +6 more
wiley +1 more source
BAG6 'mops up' mislocalized proteins [PDF]
openaire +2 more sources
ABSTRACT Background Facial nerve (CN VII) diffusion MR tractography is considered as a useful adjunct in pre‐operative planning prior to vestibular schwannoma (VS) resection, especially in larger (Koos Grade III/IV) tumors. Since 2016, several systematic reviews have investigated the clinical value of CN VII tractography in VS, and all reported a ...
Yunjia Ni +11 more
wiley +1 more source
Controlling CENPA mislocalization [PDF]
openaire +1 more source
ABSTRACT Background Recent studies suggest that disruptions of the blood–cerebrospinal fluid (CSF) barrier within the choroid plexus (ChP) may contribute to multiple sclerosis (MS) pathogenesis. We investigated the relationship between a quantitative marker of ChP enhancement and markers of focal and diffuse brain tissue injury in MS.
Sneha Senthil +10 more
wiley +1 more source
Summary The vesicle trafficking system enables multidirectional cargo fluxes between endomembrane compartments. However, vesicle trafficking plays dual roles during pathogen infections. In plants, it mediates autophagic immune responses but can also be hijacked by pathogens to facilitate successful infections.
Pepe Cana‐Quijada +9 more
wiley +1 more source
Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal +3 more
wiley +1 more source

