Results 121 to 130 of about 25,182 (194)

Characterization of Phytoene Desaturase Knockout Carotenoid‐Deficient Microalgal Mutants Generated by Cas9‐Ribonucleoprotein Complexes

Physiologia Plantarum, Volume 178, Issue 2, March/April 2026.
ABSTRACT Phytoene desaturase (PDS; EC 1.3.5.5) is a key enzyme of the carotenoid biosynthetic pathway, catalyzing the desaturation of phytoene, precursor of all carotenoids. In this study, several PDS‐knockout (PDS‐KO) transformants of the chlorophyte microalga Chlamydomonas reinhardtii were generated using a reverse genetics strategy. Two single guide
Ana Molina‐Márquez, Simon Kelterborn, Peter Hegemann, Miguel Pérez‐Rodríguez, Javier Vigara, Rosa León   +5 more
wiley   +1 more source

Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite

Traffic, Volume 27, Issue 1, March 2026.
This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light chain, and AP‐1 γ subunit were found associated with certain proteins known to be involved in cytostome function, and they were localized at the collars of ...
Jun Miao, Amuza Byaruhanga Lucky, Gang Ning, Xian Xia, Xiaoying Liang, Faiza Siddiqui, Hui Min, Chengqi Wang, Xiaolian Li, Z. Hong Zhou, Liwang Cui   +10 more
wiley   +1 more source

Characterizing TDP-43 involvement in vascular dementia. [PDF]

Alzheimers Dement
Fung M, Chai YL, Cheng YL, Tabassum N, Lim VJT, Kalaria RN, Jo DG, Chen CP, Lai MKP, Arumugam TV.   +9 more
europepmc   +1 more source

A novel <i>de novo ATP2B1</i> variant causes autosomal dominant intellectual developmental disorder 66 by disrupting calcium homeostasis via impaired membrane trafficking. [PDF]

Exp Biol Med (Maywood)
Zang H, Yang X, Liu Y, Ma C, Yang D.
europepmc   +1 more source

Chromatin remodeling activity of EP400 safeguards chromosomal stability by preventing CENP-A mislocalization. [PDF]

Cell Rep
Sethi SC, Shrestha RL, Balachandra V, Hori T, Corda L, Lin S, Ozbun L, Karpova TS, McKinnon K, Chari R, Pegoraro G, Cheng KC, Giunta S, Caplen NJ, Fukagawa T, Basrai MA.   +15 more
europepmc   +1 more source

Afadin sorts different retinal neuron types into accurate cellular layers. [PDF]

Elife
Lum MR, Patel S, Graham HK, Zhao M, Yi Y, Li L, Yao M, La Torre A, Della Santina L, Han Y, Hu Y, Welsbie DS, Duan X.   +12 more
europepmc   +1 more source

Temporal dynamics of motion compression: a lagged extrapolation account. [PDF]

R Soc Open Sci
Nakayama R, Sano H, Motoyoshi I.
europepmc   +1 more source

Splicing the narrative: alternative TARDBP splicing and its relation to neurodegeneration in ALS and FTD. [PDF]

J Clin Invest
Miller MR, Dykstra M, Barmada S.
europepmc   +1 more source

Kinesins in <i>Caenorhabditis elegans</i> neuronal morphogenesis. [PDF]

Open Biol
Niwa S, Chiba K.
europepmc   +1 more source

Ubiquitin-specific peptidase-19 links TDP-43 aggregation to ER stress. [PDF]

Proc Natl Acad Sci U S A
Yan Y, Wang X, Jeon H, Kee TR, Tran KD, Lee H, Zhao X, Liu T, Wing SS, Woo JA, Kang DE.   +10 more
europepmc   +1 more source