Results 141 to 150 of about 31,078 (242)

Acyclic artificial nucleic acid substitution expands the safe design space of gapmer ASOs by preventing P54nrb mislocalization. [PDF]

NAR Mol Med
Ariyoshi J, Higuchi M, Oyama H, Asanuma H, Kamiya Y.   +4 more
europepmc   +1 more source

Synaptic Proteostasis in Health and Disease

Journal of Neurochemistry, Volume 170, Issue 10, October 2026.
The localised creation and degradation of proteins at the pre and postsynaptic terminal are processes that are crucial for neuronal homeostasis. Synaptic proteostasis pathways are frequently reported as dysregulated in neurodevelopmental and neurodegenerative disorders.
Paul G. Donlin‐Asp, Emma L. Clayton
wiley   +1 more source

Pathogenic <i>LRSAM1</i> RING Domain Variants Disrupt Intracellular Protein Localization in Charcot-Marie-Tooth Disease Type 2P. [PDF]

Hum Mutat
Hakonen JE, Hellings TP, Dingemanse E, Laman B, Froncek OJ, NynkeWienholts, Lamzira-Arichi N, van den Berg M, Baas F, Zelcer N, Weterman MAJ.   +10 more
europepmc   +1 more source

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, Volume 126, Issue 4, Page 412-432, October 2026.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

Nim1-related kinases regulate septin organization and cytokinesis by modulating Hof1 at the cell division site. [PDF]

Elife
Bhojappa B, Dhar A, Bagyashree VT, Kumari J, Cardozo F, Rizvi V, Guturu D, Palani S.   +7 more
europepmc   +1 more source

A Ralstonia solanacearum effector RipAD perturbs aquaporin NbPIP oligomeric status to suppress plant immunity

The Plant Journal, Volume 128, Issue 1, October 2026.
SUMMARY Bacterial wilt caused by Ralstonia solanacearum is a devastating disease that affects a wide range of crops, including tobacco. The pathogen promotes infection by secreting type III effector (T3E) proteins into host plants to facilitate pathogenicity; however, the molecular mechanisms for many of these effectors remain elusive.
Bo Nian, Sai Yuan, Yijie Liu, Ying Zhang, Pengyue Li, Yang Lin, Jiatao Xie, Jiasen Cheng, Yanping Fu, Xiao Yu, Daohong Jiang, Bo Li   +11 more
wiley   +1 more source

Pathological disruption of CELF2 shuttling causes neuronal hyperactivity, learning deficits, and seizures. [PDF]

J Clin Invest
Hua M, Aghanoori MR, MacPherson MJ, Ren Y, Siripala SV, Yang Y, Or YYY, Nguyen M, Duba-Kiss R, Feng D, Williams L, Gafuik CJ, Wang G, Quelin C, Keren B, Schuhmann S, Vasileiou G, Bourgois A, Vitobello A, Philippe C, Stark Z, Leventer RJ, McGillivray G, Tran Mau-Them F, Tessarech M, Prouteau C, Lakeman P, Motazacker MM, Latner DR, Caylor RC, van Ierland Y, Prijoles E, Lichty A, Theodorou E, Sweetser DA, Steel E, Cobben J, Dasouki MJ, Calame DG, Isidor B, Cogné B, Kesler M, Rackel B, Clark I, Kurrasch DM, Teskey GC, Ellis J, He G, Ryan SD, Mahoney DJ, Innes AM, Epp JR, Yang G.   +52 more
europepmc   +1 more source

The Grammar of Impasse – Causal Mislocation

The Grammar of Impasse II: Causal Mislocation This essay argues that many influential accounts of contemporary political conflict correctly identify persistent disagreement but systematically mislocate its causes. Across political theory, moral psychology, and deliberative models of democracy, political outcomes are routinely explained in terms of ...
openaire   +2 more sources

ZmDLR9 is required for lateral root development via pre‐rRNA processing in maize

The Plant Journal, Volume 128, Issue 1, October 2026.
SUMMARY Pumilio (PUM) proteins comprise an evolutionarily conserved family of sequence‐specific RNA‐binding proteins that act as key post‐transcriptional regulators in eukaryotes. In this study, we identified a maize PUM protein, named ZmDLR9 (Defective in Lateral Root 9), as a positive factor involved in lateral root development.
Daojun Li, Yang Li, Aiming Xing, Shixian Zhang, Yanbin Zhu, Feng Wei, Haitao Zeng, Tao Zheng, Zhubing Hu, Chunfei Wang   +9 more
wiley   +1 more source

Spatial lipid-barrier coupling in knee osteoarthritis: a mechanism-based perspective centered on the infrapatellar fat pad. [PDF]

Ther Adv Musculoskelet Dis
Liu Y, Chen M, Yong R.
europepmc   +1 more source