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Tumors defective for DNA polymerase (Pol) ε proofreading have the highest tumor mutation burden identified. A major unanswered question is whether loss of Pol ε proofreading by itself is sufficient to drive this mutagenesis, or whether additional factors
Karl P Hodel +12 more
doaj +1 more source
A differentiable BLEU loss. Analysis and first results [PDF]
In natural language generation tasks, like neural machine translation and image captioning, there is usually a mismatch between the optimized loss and the de facto evaluation criterion, namely token-level maximum likelihood and corpus-level BLEU score ...
Casas Manzanares, Noé +2 more
core
Association between family history and mismatch repair in colorectal cancer [PDF]
BACKGROUND AND AIMS: Germline mutations in mismatch repair (MMR) genes cause a greatly increased risk of cancer of the gastrointestinal and female reproductive tracts (hereditary non-polyposis colorectal cancer (HNPCC)).
Bell, S.M. +6 more
core +2 more sources
Screen‐Printed Flexible Piezoelectric Force Sensor Array with Electromagnetic Interference Shielding
This article introduces a flexible screen‐printed piezoelectric sensor array designed for low‐frequency healthcare applications such as tactile sensing and cardiovascular monitoring. The device integrates interface electronics enabling the simultaneous acquisition of up to 128 signals, along with flexible EMI shielding that significantly reduces noise ...
Joseph Faudou +6 more
wiley +1 more source
PMS2 variant results in loss of ATPase activity without compromising mismatch repair
Hereditary cancer syndromes account for approximately 5%–10% of all diagnosed cancer cases. Lynch syndrome (LS) is an autosomal dominant hereditary cancer condition that predisposes individuals to an elevated lifetime risk for developing colorectal ...
Brandon M. D'Arcy +8 more
doaj +1 more source
The thermal diffusivity of MgO‐C refractories is highly sensitive to sample preparation and processing procedures. In this article, the effects of coking sequence, machining conditions, structural inhomogeneity, and graphite coating application on measurements using laser flash apparatus are systematically investigated.
Luyao Pan +4 more
wiley +1 more source
A wood‐based magnetic and conductive material called Magwood (MW), capable of blocking almost 99.99% of electromagnetic waves (in the X‐band frequency range), is synthesized using a simple, solvent‐free process. MW is lightweight, resists water, and is flame‐retardant, making it a promising alternative for shielding electronics. The rapid proliferation
Akash Madhav Gondaliya +3 more
wiley +1 more source
Ground-installed PV power-systems are usually built in parallel-rows; each is composed of series-connected modules. With time, some modules got-polluted or −shaded differently. On damage, some modules may be replaced by others of different ratings.
Reham Kamal +2 more
doaj +1 more source
Potential predictors for CDX2 expression loss and mismatch repair deficiency in colorectal cancer
CDX2 expression loss is commonly associated with mismatch repair deficiency (dMMR) in colorectal cancer (CRC). However, there are only a few studies that have attempted to correlate CDX2 expression loss with specific MMR genes (MLH1, MSH2, MSH6, PMS2 ...
Ivan Vlahović +4 more
doaj +1 more source
Optical Properties of BN in the cubic and in the layered hexagonal phases
Linear optical functions of cubic and hexagonal BN have been studied within first principles DFT-LDA theory. Calculated energy-loss functions compare well with experiments and previous theoretical results both for h-BN and for c-BN.
Cappellini, Giancarlo +3 more
core +1 more source

