Results 41 to 50 of about 151,537 (305)

Loss of Cdx2 expression in primary tumors and lymph node metastases is specific for mismatch repair-deficiency in colorectal cancer [PDF]

, 2013
Background: Approximately 20% of all colorectal cancers are hypothesized to arise from the serrated pathway characterized by mutation in BRAF, high-level CpG Island Methylator Phenotype (CIMP) and microsatellite instability/mismatch repair (MMR ...
Makhmudbek eMallaev, Daniel Inderbitzin, Lukesch, Anne C, Lukesch, Anne C., Mallaev, Makhmudbek, Zlobec, Inti, Makhmudbek Mallaev, Alessandro Lugli, Anne C. Lukesch, Inderbitzin, Daniel, Heather eDawson, Heather Dawson, Inti Zlobec, Koelzer, Viktor H; https://orcid.org/, Daniel eInderbitzin, Lugli, Alessandro, Dawson, Heather, Viktor H. Koelzer, Inti eZlobec, Alessandro eLugli, Anne eLukesh, Viktor Hendrik Koelzer, Kölzer, Viktor H.   +22 more
core   +1 more source

Causes and Evolution Characteristics of Green Innovation Efficiency Loss: The Perspective of Factor Mismatch under Local Government Competition [PDF]

, 2022
The objective of this paper is to measure the efficiency loss of green innovation caused by local government competition and explore its causes and evolution characteristics. Based on the equimarginal principles such as the deviation of the allocation of
Xinliang Wang, Fei Liu, Ting Nan
core   +1 more source

Mitigation of mismatch losses in solar PV systems: a hybrid L-shaped propagated array configuration approach

Frontiers in Energy Research
There has been a global expansion of solar electricity during the past decades. Solar photovoltaic (PV) electricity generation is not only simple but also environmentally benign and cost-effective.
Belqasem Aljafari, S. Devakirubakaran, Praveen Kumar Balachandran, Sudhakar Babu Thanikanti   +3 more
doaj   +1 more source

Power enhanced solar PV array configuration based on calcudoku puzzle pattern for partial shaded PV system

Heliyon, 2023
The power output of solar photovoltaic systems can be affected by environmental factors, such as partial shading. This can lead to a decrease in the power conversion rate of the system.
Belqasem Aljafari, Devakirubakaran S, Bharatiraja C, Praveen Kumar Balachandran, Thanikanti Sudhakar Babu   +4 more
doaj   +1 more source

Effects of Gain-Loss Frames in Negotiation: Loss Aversion, Mismatching, and Frame Adoption [PDF]

Organizational Behavior and Human Decision Processes, 1994
Examined negotiator cognition and behavior as a function of own frame, foreknowledge about opponent's frame, opponent's communicated frame, and their interactions. Prenegotiation information about the opponent's gain or loss frame on negotiator cognition and behavior was also examined. Ss were 107 undergraduates.
de Dreu, C.K.W., Carnevale, P.J.D., Emans, B.J.M., van de Vliert, E.   +3 more
openaire   +4 more sources

Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort [PDF]

, 2009
Includes abstract.Includes bibliographical references (leaves 106-120).To date, surgery is the mainstay treatment for HNPCC. Adjuvant chemotherapy and radiotherapy are often used to reduce systemic and locoregional recurrence, respectively, after ...
Meyer, Jacqueline
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Event-related potential studies of somatosensory detection and discrimination. [PDF]

, 2007
This thesis contains four studies, the first examining methodology issues and four subsequent ones examining somatosensory cortical processing using event-related potentials (ERPs). The methodology section consists of 2 experiments.
Spackman, L.
core  

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source