Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2005 Aberrant expression of mismatch repair genes, such as human mutL homolog 1 (hMLH1) and human mutS homolog 2 (hMSH2), are common in some human cancers, and promoter methylation is believed to inactivate expression of hMLH1. We investigated whether promoter methylation is involved in loss of hMLH1 protein and whether aberrant expression of hMLH1 and ...
Ching, Tzao +9 more
openaire +4 more sources
Indian Journal of Pathology and MicrobiologyBackground: The development of colorectal carcinoma is a complicated multistep process that involves the accumulation of mutations in tumor suppressor genes and oncogenes.
Eshita Garg +5 more
doaj +2 more sources
The Keynote-177 Randomized Controlled Trial of First-line PD-1 Blockade for Microsatellite-High or Mismatch Repair-Deficient Advanced Colorectal Cancer: Potential Consequences of the Cross-Over Trial Design and Related Issues. [PDF]
Cancer MedABSTRACT Some new oncology drugs offer substantial patient health benefit. However, due to high costs, many remain unavailable to patients in low‐ and middle‐income countries. Next to exorbitant drug pricing, uncertainty of the magnitude of benefit of new treatments can contribute to differences in global access to cancer treatments, even in high ...
Gerritse SL +3 more
europepmc +2 more sources
Expression and prognostic significance of MLH1 and GPRC5C in resectable hepatocellular carcinoma [PDF]
BMC CancerBackground It has recently been shown that mut-L homolog 1 (MLH1), frequently lost in cancer initiation and progression, inhibited pancreatic cancer metastatic potential by downregulating G-protein coupled receptor C5C (GPRC5C). However, their expression
Jun Lu +12 more
doaj +2 more sources
Establishment of a Model to Predict the Prognosis of Endometrial Carcinoma Using Tumor‐Infiltrating Lymphocytes Evaluated With Artificial Intelligence: A Retrospective Analysis [PDF]
Cancer Rep (Hoboken)ABSTRACT Background The objective of this study was to establish a new model for predicting the prognosis of endometrial carcinoma (EC) using tumor‐infiltrating lymphocytes (TILs) based on artificial intelligence (AI). Methods Patients with EC who were treated between 1989 and 2022 were included in this study.
Hada T +17 more
europepmc +2 more sources
The GHKL ATPase Family as a Paradigm for MutL Homolog Function in DNA Mismatch Repair. [PDF]
Int J Mol SciPiscitelli JM, Manhart CM.
europepmc +2 more sources
Translational Oncology, 2022 Most tumors, including osteosarcomas, have deficiencies in DNA damage repair. However, the regulatory mechanisms underlying dysregulation of DNA damage repair genes are still being investigated.
Xun Chen +7 more
doaj +1 more source
Scientific Reports, 2022 The methylation status of the O6-methylguanine methyltransferase (MGMT) gene promoter has been widely accepted as a prognostic biomarker for treatment with the alkylator, temozolomide (TMZ). In the absence of promoter methylation, the MGMT enzyme removes
Sachita Ganesa +3 more
doaj +1 more source
PLoS ONE, 2022 Synthetic lethality in DNA repair pathways is an important strategy for the selective treatment of cancer cells without harming healthy cells and developing cancer-specific drugs. The synthetic lethal interaction between the mismatch repair (MMR) protein,
Berna Somuncu +12 more
doaj +3 more sources
Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae. [PDF]
, 2014 In Saccharomyces cerevisiae, the essential mismatch repair (MMR) endonuclease Mlh1-Pms1 forms foci promoted by Msh2-Msh6 or Msh2-Msh3 in response to mispaired bases. Here we analyzed the Mlh1-Mlh2 complex, whose role in MMR has been unclear.
Bowen, Nikki +7 more
core +6 more sources