Results 1 to 10 of about 33,127 (201)

Identifying primary and secondary MLH1 epimutation carriers displaying low-level constitutional MLH1 methylation using droplet digital PCR and genome-wide DNA methylation profiling of colorectal cancers

Clinical Epigenetics, 2023
Background MLH1 epimutation is characterised by constitutional monoallelic MLH1 promoter hypermethylation, which can cause colorectal cancer (CRC). Tumour molecular profiles of MLH1 epimutation CRCs were used to classify germline MLH1 promoter variants ...
Jihoon E. Joo, Khalid Mahmood, Romy Walker, Peter Georgeson, Ida Candiloro, Mark Clendenning, Julia Como, Sharelle Joseland, Susan Preston, Lise Graversen, Mathilda Wilding, Michael Field, Michelle Lemon, Janette Wakeling, Helen Marfan, Rachel Susman, Joanne Isbister, Emma Edwards, Michelle Bowman, Judy Kirk, Emilia Ip, Lynne McKay, Yoland Antill, John L. Hopper, Alex Boussioutas, Finlay A. Macrae, Alexander Dobrovic, Mark A. Jenkins, Christophe Rosty, Ingrid M. Winship, Daniel D. Buchanan   +30 more
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The marsupial imprinted gene MLH1 has retrocopies in three marsupial families [PDF]

Epigenetics & Chromatin
Background The mut-L homologue 1 gene (MLH1) is a DNA repair gene. Loss of biallelic expression of MLH1 in humans leads to increased predisposition to several cancer types. In the koala (Phascolarctos cinereus) and brushtail possum (Trichosurus vulpecula)
Jenna Pride, Geoff Shaw, Marilyn B. Renfree, Trent A. C. Newman   +3 more
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Structural insights into the MLH1–FAN1 interaction reveal an uncharacterized binding interface on MLH1 [PDF]

Nature Communications
Huntington’s disease is driven by CAG repeat expansion in the mutant huntingtin gene. Nuclease FAN1 and mismatch repair protein MLH1 regulate repeat expansion through direct interaction, but the underlying structural basis remains unclear.
Yichang Chen, Haiyun Hu, Xinci Shang, Keri M. Fishwick, Giada Greco, Qin Xiao, Yinhao Zhou, Qiuyan Huang, Tao Jiang, Xiaolei Huang, Guanghui Wang, Xuechu Zhen, Guoqiang Xu, Su Qin, Alessandro A. Sartori, Yanli Liu   +15 more
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Hesperetin effect on MLH1 and MSH2 expression on breast cancer cells BT-549

Journal of Advanced Pharmaceutical Technology & Research, 2023
Due to its genetic and phenotypic heterogeneity, breast cancer is very difficult to eliminate. The harmful consequences of conventional therapies like radiation and chemotherapy have prompted the search for organic-based alternatives. Hesperetin (HSP), a
Assim Khattab Hasan, Esmaeil Babaei, Ahmed Salim Kadhim Al-Khafaji   +2 more
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Hereditary ovarian cancer

Сибирский онкологический журнал, 2022
Background. Hereditary genetic mutations are a significant risk factor for malignant transformation of cells and cancer development. Hereditary genetic mutations account for 15 to 25 % of all ovarian carcinomas. Purpose of the study: to summarize data on
Kh. B. Kotiv, T. V. Gorodnova, A. P. Sokolenko, I. V. Berlev, E. N. Imyanitov   +4 more
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Two distinct deleterious causative variants in a family with multiple cancer-affected patients

Advanced Biomedical Research, 2023
Background: Only 5 to 10% of cancers are hereditary, but they are particularly important since they can be passed down from generation to generation, and family members are at elevated risk.
Erfan Khorram, Mohammad A Tabatabaiefar, Mehrdad Zeinalian   +2 more
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Negative heterosis for meiotic recombination rate in spermatocytes of the domestic chicken Gallus gallus

Вавиловский журнал генетики и селекции, 2021
Benefits and costs of meiotic recombination are a matter of discussion. Because recombination breaks allele combinations already tested by natural selection and generates new ones of unpredictable fitness, a high recombination rate is generally ...
L. P. Malinovskaya, K. V. Tishakova, T. I. Bikchurina, A. Yu. Slobodchikova, N. Yu. Torgunakov, A. A. Torgasheva, Y. A. Tsepilov, N. A. Volkova, P. M. Borodin   +8 more
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Relationship between the expression of mismatch repair proteins and colorectal cancer with mesenteric tumor deposit

Zhongguo linchuang yanjiu, 2023
Objective To investigate the clinicopathological significance of colorectal cancer with mesenteric tumor deposit(TD) and the relationship with DNA mismatch repair(MMR) protein expression.
HUANG Ke-qiang, TANG Hua, HUANG Qiu-xia, OU Hai-ling
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MLH1 mediates cytoprotective nucleophagy to resist 5-Fluorouracil-induced cell death in colorectal carcinoma

Neoplasia: An International Journal for Oncology Research, 2022
Colorectal Cancer (CRC) with Microsatellite instability (MSI) and mutLhomolog-1 (MLH1) gene deficiency are less aggressive than MLH1 proficient cancers.
Shaista Manzoor, Maha Saber-Ayad, Azzam A. Maghazachi, Qutayba Hamid, Jibran Sualeh Muhammad   +4 more
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Hepatica transsilvanica Fuss (Ranunculaceae) is an Allotetraploid Relict of the Tertiary Flora in Europe – Molecular Phylogenetic Evidence

Acta Societatis Botanicorum Poloniae, 2020
The Hepatica section Angulosa consists of mainly tetraploid (2n = 28) species that are distributed disjunctly throughout Eurasia. Karyological evidence proves the hybrid origin of the polyploid species of this section. Hepatica transsilvanica is a member
Levente Laczkó, Gábor Sramkó
doaj   +1 more source