Haploinsufficiency by minute MutL homolog 1 promoter DNA methylation may represent unique phenotypes of microsatellite instability-gastric carcinogenesis. [PDF]
PLoS ONE, 2021 Promoter DNA methylation of MutL homolog 1 (MLH1) is considered to play a causative role in microsatellite instability (MSI) carcinogenesis in primary gastric cancer, and a high MSI status is associated with treatment sensitivity to human cancers ...
Hiroki Harada +14 more
doaj +5 more sources
Overexpression of MutL homolog 1 and MutS homolog 2 proteins have reversed prognostic implications for stage I–II colon cancer patients [PDF]
Biomedical Journal, 2017 Background: The outcome of colon cancer patients without lymph node metastasis is heterogeneous. Searching for new prognostic markers is warranted. Methods: One hundred twenty stage I–II colon cancer patients who received complete surgical excision ...
Shih-Chiang Huang +7 more
doaj +4 more sources
A new mutL homolog 1 c.1896+5G>A germline mutation detected in a Lynch syndrome‐associated lung and gastric double primary cancer patient [PDF]
Molecular Genetics & Genomic Medicine, 2019 Background Mismatch‐repair genes (MMRs) ensure high fidelity in genome editing. Loss of function mutation of MMRs will lead to instability of the genome and increase the incidence of cancers.
Xuyuan Chen +6 more
doaj +5 more sources
Prevalence of somatic mutl homolog 1 promoter hypermethylation in Lynch syndrome colorectal cancer [PDF]
Cancer, 2015 BACKGROUNDColorectal cancers (CRCs) that have microsatellite instability (MSI) and mutL homolog 1 (MLH1) immunoloss are observed in 3 clinical scenarios: Lynch syndrome (LS), sporadic MSI CRC, and Lynch‐like syndrome (LLS). v‐Raf murine sarcoma viral oncogene homolog B1 (BRAF) mutational analysis is used to differentiate LS from sporadic MSI CRC.
Leticia Moreira +2 more
exaly +6 more sources
MutL homolog 1 participates in interference-sensitive meiotic crossover formation in soybean [PDF]
Plant PhysiologyAbstract MutL homolog 1 (MLH1), a member of the MutL homolog family, is required for normal recombination in most organisms. However, its role in soybean (Glycine max) remains unclear to date. Here, we characterized the Glycine max female and male sterility 1 (Gmfms1) mutation that reduces pollen grain viability and increases embryo sac ...
Tao Wu, Suxin Yang, Junling Fang
exaly +4 more sources
Expression and prognostic significance of MLH1 and GPRC5C in resectable hepatocellular carcinoma [PDF]
BMC CancerBackground It has recently been shown that mut-L homolog 1 (MLH1), frequently lost in cancer initiation and progression, inhibited pancreatic cancer metastatic potential by downregulating G-protein coupled receptor C5C (GPRC5C). However, their expression
Jun Lu +12 more
doaj +2 more sources
Explore the dominant factor in prime editing via a view of DNA processing
Synthetic and Systems Biotechnology, 2023 Prime editing is a revolutionary gene-editing method that is capable of introducing insertions, deletions and base substitutions into the genome. However, the editing efficiency of Prime Editor (PE) is limited by the DNA repair process.
Zhimeng Xu +6 more
doaj +1 more source
The GHKL ATPase Family as a Paradigm for MutL Homolog Function in DNA Mismatch Repair [PDF]
International Journal of Molecular SciencesCarol Manhart
exaly +2 more sources
Scientific Reports, 2022 The methylation status of the O6-methylguanine methyltransferase (MGMT) gene promoter has been widely accepted as a prognostic biomarker for treatment with the alkylator, temozolomide (TMZ). In the absence of promoter methylation, the MGMT enzyme removes
Sachita Ganesa +3 more
doaj +1 more source
Translational Oncology, 2022 Most tumors, including osteosarcomas, have deficiencies in DNA damage repair. However, the regulatory mechanisms underlying dysregulation of DNA damage repair genes are still being investigated.
Xun Chen +7 more
doaj +1 more source