Results 31 to 40 of about 5,198 (143)

A novel function for CDK2 activity at meiotic crossover sites.

PLoS Biology, 2020
Genetic diversity in offspring is induced by meiotic recombination, which is initiated between homologs at >200 sites originating from meiotic double-strand breaks (DSBs).
Nathan Palmer, S Zakiah A Talib, Priti Singh, Christine M F Goh, Kui Liu, John C Schimenti, Philipp Kaldis   +6 more
doaj   +1 more source

Immunohistochemistry Staining for the Mismatch Repair Proteins in Endometrial Cancer Patients

Thai Journal of Obstetrics and Gynaecology, 2020
Objectives: Lynch syndrome (LS) increases the lifetime risks of endometrial cancer by approximately 40-60%. Although universal screening with immunohistochemistry (IHC) for mismatch repair (MMR) proteins has been recommended, it is not yet common in ...
Pimpitcha Puangsricharoen, Tarinee Manchana, Chai Ariyasriwatana, Surang Triratanachat   +3 more
doaj   +1 more source

Expression of programmed cell death ligand-1 and mismatch repair status in endometrial carcinomas

Journal of Mid-Life Health, 2023
Background and Aims: Programmed death ligand-1 (PD-L1) is a co-regulatory molecule that suppresses local immunity, and mismatch repair (MMR) deficiency (dMMR) is reported to influence the response to anti-PD-L1-targeted therapy.
Madhubala Rajendran, Meenakshi Rao, Poonam Abhay Elhence, Jyotsna Naresh Bharti, Pratibha Singh, Garima Yadav, Aasma Nalwa, Akhil Dhanesh Goyal   +7 more
doaj   +1 more source

MutL homolog 1 contributes to temozolomide-induced autophagy via ataxia-telangiectasia mutated in glioma

Molecular Medicine Reports, 2015
In the present study, mutL homolog 1 (MLH1) small interfering (si)RNA, KU‑55933, an ataxia‑telangiectasia mutated (ATM) inhibitor, and compound C, an adenosine monophosphate‑activated protein kinase (AMPK) inhibitor, were used to investigate the mechanisms underlying temozolomide (TMZ)‑induced autophagy and to determine the role of MLH1 and ATM in ...
Yuhui, Zou, Qiong, Wang, Weimin, Wang
openaire   +3 more sources

Differential Expression and Clinical Significance of DNA Methyltransferase 3B (DNMT3B), Phosphatase and Tensin Homolog (PTEN) and Human MutL Homologs 1 (hMLH1) in Endometrial Carcinomas [PDF]

Medical Science Monitor, 2017
BACKGROUND The aim of this study was to investigate the expression and the clinicopathologic significance of DNA methyltransferase 3B (DNMT3B), phosphatase and tensin homolog (PTEN) and human MutL homologs 1 (hMLH1) in endometrial carcinomas between Han and Uygur women in Xinjiang.
Li, Wenting, Wang, Ying, Fang, Xinzhi, Zhou, Mei, Li, Yiqun, Dong, Ying, Wang, Ruozheng   +6 more
openaire   +2 more sources

Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.

PLoS Genetics, 2021
Histone methylation is dynamically regulated to shape the epigenome and adjust central nuclear processes including transcription, cell cycle control and DNA repair.
Xiaojuan Zhang, Sisi Tian, Sara E Beese-Sims, Jingjie Chen, Nara Shin, Monica P Colaiácovo, Hyun-Min Kim   +6 more
doaj   +1 more source

Expression of PD-L1 in Microsatellite Instability High Tumours: A Retrospective Study [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Microsatellite Instability (MSI) is the hallmark of Lynch syndrome/Constitutional Mismatch Repair Deficiency (CMMRD) and is also found in many sporadic cancers like colorectal cancer, endometrial, gastric, small intestine, urothelial ...
Dinisha Einstien, Gayathri Devi Thanigaimani, KS Mouleeswaran, A Prathiba, G Sarumathy, John Vergilin   +5 more
doaj   +1 more source

Establishment of a Model to Predict the Prognosis of Endometrial Carcinoma Using Tumor‐Infiltrating Lymphocytes Evaluated With Artificial Intelligence: A Retrospective Analysis [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background The objective of this study was to establish a new model for predicting the prognosis of endometrial carcinoma (EC) using tumor‐infiltrating lymphocytes (TILs) based on artificial intelligence (AI). Methods Patients with EC who were treated between 1989 and 2022 were included in this study.
Hada T, Miyamoto M, Einama T, Kakimoto S, Koga M, Watanabe T, Otsuka Y, Suminokura J, Ito T, Kishimoto N, Tanabe R, Nishimura S, Kato K, Soyama H, Omatsu K, Hamada Y, Sato K, Takano M.   +17 more
europepmc   +2 more sources

Mismatch repair genes in Lynch syndrome: a review

São Paulo Medical Journal
Lynch syndrome represents 1-7% of all cases of colorectal cancer and is an autosomal-dominant inherited cancer predisposition syndrome caused by germline mutations in deoxyribonucleic acid (DNA) mismatch repair genes.
Felipe Cavalcanti Carneiro da Silva, Mev Dominguez Valentin, Fábio de Oliveira Ferreira, Dirce Maria Carraro, Benedito Mauro Rossi   +4 more
doaj   +1 more source

Monosodium glutamate-induced alterations in MMR protein expression: A potential mechanism linking diet and colorectal cancer

Gastroenterology & Endoscopy
Background: Defective mismatch repair (MMR) proteins activate the microsatellite instability (MSI) pathway, contributing to colon carcinogenesis. Monosodium glutamate (MSG), a widely used flavor enhancer, has been implicated in colorectal cancer (CRC ...
Meenakshi Sundari Rajendran, Rajkumar Prabhakaran, Padma Malini Ravi   +2 more
doaj   +1 more source