Results 21 to 30 of about 5,198 (143)

Human MutL homolog 1 immunoexpression in oral leukoplakia and oral squamous cell carcinoma: A prospective study in Indian population.

J Oral Maxillofac Pathol, 2016
Mammalian mismatch repair system is responsible for maintaining genomic stability during repeated duplications, and human MutL homolog 1 (hMLH1) protein constitutes an important part of it. Various isolated studies have reported the altered expression of hMLH1 in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC).
Chaudhari NT, Tupkari JV, Joy T, Ahire MS.   +3 more
europepmc   +4 more sources

The Keynote-177 Randomized Controlled Trial of First-line PD-1 Blockade for Microsatellite-High or Mismatch Repair-Deficient Advanced Colorectal Cancer: Potential Consequences of the Cross-Over Trial Design and Related Issues. [PDF]

Cancer Med
ABSTRACT Some new oncology drugs offer substantial patient health benefit. However, due to high costs, many remain unavailable to patients in low‐ and middle‐income countries. Next to exorbitant drug pricing, uncertainty of the magnitude of benefit of new treatments can contribute to differences in global access to cancer treatments, even in high ...
Gerritse SL, van Meerten E, Duits AJ, Schnog JB.   +3 more
europepmc   +2 more sources

Identification of a novel pathogenic MLH1 mutation and recommended genetic screening strategy: An investigation of three Chinese Lynch syndrome pedigrees

Molecular Genetics & Genomic Medicine, 2020
Background Lynch syndrome (LS) is an autosomal‐dominant disorder that increases the risk of many cancers. The genetic basis of LS is germline mutations in DNA mismatch repair genes.
Fan Li, Yunwei Xia, Guoguang Wang, Chaoyang Tang, Tian Zhan, Jian Shen, Jianping Zhang   +6 more
doaj   +1 more source

Development of a liquid biopsy based purely quantitative digital droplet PCR assay for detection of MLH1 promoter methylation in colorectal cancer patients

BMC Cancer, 2021
Background MutL Homolog 1 (MLH1) promotor methylation is associated with microsatellite instability high colorectal cancer (CRC). The strong correlation between methylation status and cancer development and progression has led to a growing interest in ...
Danyi Wang, Dennis O’Rourke, Jorge F. Sanchez-Garcia, Ti Cai, Juergen Scheuenpflug, Zheng Feng   +5 more
doaj   +1 more source

Early Initiation of Temozolomide Therapy May Improve Response in Aggressive Pituitary Adenomas

Frontiers in Endocrinology, 2021
IntroductionAggressive pituitary adenomas (APAs) are, by definition, resistant to optimal multimodality therapy. The challenge lies in their early recognition and timely management.
Liza Das, Nidhi Gupta, Pinaki Dutta, Rama Walia, Kim Vaiphei, Ashutosh Rai, Bishan Dass Radotra, Kirti Gupta, Sreejesh Sreedharanunni, Chirag Kamal Ahuja, Anil Bhansali, Manjul Tripathi, Ridhi Sood, Sivashanmugam Dhandapani   +13 more
doaj   +1 more source

MutL homolog 1 expression in thyroid carcinoma and its clinical significance

Journal of Cancer Research and Therapeutics, 2016
The aim of this study was to evaluate the MutL homolog 1 (MLH1) protein expression in thyroid cancer patients and its association with clinical pathological characteristics.Forty thyroid cancer tissues and 22 partial paired normal thyroid tissues from 40 thyroid cancer patients who received surgery were collected in this study.
Yi, Lu, Baocheng, Jiang, Ye, Yuan, Jianping, Fei, Jiyuan, Wang   +4 more
openaire   +2 more sources

A retrotransposon insertion in MUTL-HOMOLOG 1 affects wild rice seed set and cultivated rice crossover rate

Plant Physiology, 2022
Abstract Wild rice (Oryza rufipogon) has a lower panicle seed setting rate (PSSR) and gamete fertility than domesticated rice (Oryza sativa), but the genetic mechanisms of this phenomenon remain unknown. Here, we cloned a null allele of OsMLH1, an ortholog of MutL-homolog 1 to yeast and mammals, from wild rice O.
Kun Liu, Erwang Chen, Zhoulin Gu, Bingxin Dai, Ahong Wang, Zhou Zhu, Qi Feng, Congcong Zhou, Jingjie Zhu, Yingying Shangguan, Yongchun Wang, Zhen Li, Qingqing Hou, Danfeng Lv, Changsheng Wang, Tao Huang, Zixuan Wang, Xuehui Huang, Bin Han   +18 more
openaire   +2 more sources

MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her‐2/PI3K/AKT Signaling

Advanced Science, 2020
The rapid onset of resistance to cetuximab (CTX) limits its clinical utility in colorectal cancer (CRC) patients. This study aims to understand a potential role of mismatch repair gene mutL homolog 1 (MLH1) in CTX response. Functional analysis of MLH1 in
Ying Han, Yinghui Peng, Yaojie Fu, Changjing Cai, Cao Guo, Shanshan Liu, Yiyi Li, Yihong Chen, Edward Shen, Kexin Long, Xinwen Wang, Jian Yu, Hong Shen, Shan Zeng   +13 more
doaj   +1 more source

Identification of Driving ALK Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer. [PDF]

PLoS Genetics, 2015
The genetic landscape of medullary thyroid cancer (MTC) is not yet fully understood, although some oncogenic mutations have been identified. To explore genetic profiles of MTCs, formalin-fixed, paraffin-embedded tumor tissues from MTC patients were ...
Jun Ho Ji, Young Lyun Oh, Mineui Hong, Jae Won Yun, Hyun-Woo Lee, DeokGeun Kim, Yongick Ji, Duk-Hwan Kim, Woong-Yang Park, Hyun-Tae Shin, Kyoung-Mee Kim, Myung-Ju Ahn, Keunchil Park, Jong-Mu Sun   +13 more
doaj   +1 more source

Promoter methylation of human mutL homolog 1 and colorectal cancer risk

Journal of Cancer Research and Therapeutics, 2018
Several studies suggested that promoter methylation of human mutL homolog 1 (hMLH1) was associated with the risk of colorectal cancer (CRC). However, other studies did not indicate the same results. To derive a more comprehensive estimation of the association between hMLH1 methylation and CRC risk, we conducted a meta-analysis.We searched in the PubMed,
Bian, Shi, Junfeng, Chu, Qilong, Gao, Tongde, Tian   +3 more
openaire   +2 more sources