Results 1 to 10 of about 23,834 (214)
MSH6 gene methylation on clinical pathology and diagnosis in retinoblastoma: a bioinformatics analysis [PDF]
International Journal of OphthalmologyAIM: To explore the methylation status of MSH6 in retinoblastoma (RB) and its impact on clinicopathological features and diagnosis. METHODS: Differentially expressed genes were identified through bioinformatics screening of the GSE24673 and GSE125903 ...
Cheng-Fang Zhang +3 more
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Cooperative nuclear localization sequences lend a novel role to the N-terminal region of MSH6. [PDF]
PLoS ONE, 2011 Human mismatch repair proteins MSH2-MSH6 play an essential role in maintaining genetic stability and preventing disease. While protein functions have been extensively studied, the substantial amino-terminal region (NTR*) of MSH6 that is unique to ...
Natalie R Gassman +5 more
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Zhongguo linchuang yanjiu, 2023 Objective To investigate the clinicopathological significance of colorectal cancer with mesenteric tumor deposit(TD) and the relationship with DNA mismatch repair(MMR) protein expression.
HUANG Ke-qiang, TANG Hua, HUANG Qiu-xia, OU Hai-ling
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Сибирский онкологический журнал, 2022 Background. Hereditary genetic mutations are a significant risk factor for malignant transformation of cells and cancer development. Hereditary genetic mutations account for 15 to 25 % of all ovarian carcinomas. Purpose of the study: to summarize data on
Kh. B. Kotiv +4 more
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A simplified two-marker immunohistochemistry strategy for Lynch syndrome screening in endometrial cancer patients [PDF]
Obstetrics & Gynecology Science, 2023 Objective To examine the efficacy of MSH6 and PMS2 immunohistochemistry (IHC) as a screening method for Lynch syndrome in endometrial cancer patients.
Ala Aiob +9 more
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Functional analysis in mouse embryonic stem cells reveals wild-type activity for three MSH6 variants found in suspected Lynch syndrome patients. [PDF]
PLoS ONE, 2013 Lynch syndrome confers an increased risk to various types of cancer, in particular early onset colorectal and endometrial cancer. Mutations in mismatch repair (MMR) genes underlie Lynch syndrome, with the majority of mutations found in MLH1 and MSH2 ...
Eva A L Wielders +3 more
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ACR Open Rheumatology, 2022 Objective To determine if single‐nucleotide polymorphisms (SNPs) in DNA repair genes are enriched in individuals with systemic lupus erythematosus (SLE) and if they are sufficient to confer a disease phenotype in a mouse model.
Rithy Meas +12 more
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Frontiers in Cellular and Infection Microbiology, 2020 MSH2, associated with MSH3 or MSH6, is a central component of the eukaryotic DNA Mismatch Repair (MMR) pathway responsible for the recognition and correction of base mismatches that occur during DNA replication and recombination.
Viviane Grazielle-Silva +6 more
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Combined MLH1/MSH2/MSH6 assessment by IHC and RT-qPCR: Differential expression analysis and incremental value for pathological risk stratification in colorectal cancer [PDF]
Journal of Medical BiochemistryBackground: Mismatch repair (MMR) status is routinely assessed in colorectal cancer (CRC), yet the laboratory value of combining multiple MMR targets across platforms for risk stratification requires verification under real-world testing conditions. This
Zhang Yi +3 more
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Frontiers in Oncology, 2022 Immunohistochemical analysis of mismatch repair (MMR) protein expression is widely used to identify tumors with a deficient MMR (dMMR). MMR proteins (MLH1/PMS2 and MSH2/MSH6) work as functional heterodimers, which usually leads to the loss of expression ...
Nic Gabriel Reitsam +5 more
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