MGMT and MSH6 immunoexpression for functioning pituitary macroadenomas [PDF]
Pituitary, 2017 Knowledge of biological behavior is crucial for clinical management of functioning pituitary macroadenomas. For recurrent cases unresponsive to standard treatment, temozolomide (TMZ) has been used as a therapeutic alternative. MGMT (O6-methyl-guanine-DNA methyltransferase) and MSH6 (mutS homolog 6) immunoexpression have been linked to the response to ...
Micko, Alexander S. G. +6 more
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An Escherichia coli effector protein promotes host mutation via depletion of DNA mismatch repair proteins. [PDF]
, 2013 Enteropathogenic Escherichia coli (EPEC) is an attaching and effacing (A/E) human pathogen that causes diarrhea during acute infection, and it can also sustain asymptomatic colonization. A/E E.
Donnenberg, Michael S. +2 more
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Hereditary Cancer in Clinical Practice, 2010 Background Approximately 10% of Lynch syndrome families have a mutation in MSH6 and fewer families have a mutation in PMS2. It is assumed that the cancer incidence is the same in families with mutations in MSH6 as in families with mutations in MLH1/MSH2 ...
Talseth-Palmer Bente A +4 more
doaj +1 more source
Mismatch repair enzyme expression in primary and castrate resistant prostate cancer
Asian Journal of Urology, 2016 Objective: Although the utility of immunohistochemistry (IHC) for assessing mismatch repair (MMR) protein expression has been demonstrated in solid tumors including primary prostate cancer (PCa), its utility has not been assessed in castration-resistant ...
Belinda Nghiem +8 more
doaj +1 more source
Multiple functions for the N-terminal region of Msh6 [PDF]
Nucleic Acids Research, 2007 The eukaryotic mismatch repair protein Msh6 shares five domains in common with other MutS members. However, it also contains several hundred additional residues at its N-terminus. A few of these residues bind to PCNA, but the functions of the other amino acids in the N-terminal region (NTR) are unknown.
Clark, Alan B. +3 more
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Modulation of gene expression in endothelial cells in response to high LET nickel ion irradiation [PDF]
, 2014 Ionizing radiation can elicit harmful effects on the cardiovascular system at high doses. Endothelial cells are critical targets in radiation-induced cardiovascular damage.
Aerts, An +15 more
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Suspected Lynch syndrome associated MSH6 variants: A functional assay to determine their pathogenicity. [PDF]
PLoS Genetics, 2017 Lynch syndrome (LS) is a hereditary cancer predisposition caused by inactivating mutations in DNA mismatch repair (MMR) genes. Mutations in the MSH6 DNA MMR gene account for approximately 18% of LS cases. Many LS-associated sequence variants are nonsense
Hellen Houlleberghs +10 more
doaj +1 more source
Complex-based analysis of dysregulated cellular processes in cancer [PDF]
, 2014 Background: Differential expression analysis of (individual) genes is often used to study their roles in diseases. However, diseases such as cancer are a result of the combined effect of multiple genes.
Khanna, Kum Kum +6 more
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DNA methylation of selected tumor suppressor genes in endometrial hyperplasia
Biomedical PapersAims. To investigate DNA methylation of specific gene promoters in endometrial hyperplasia compared to normal endometrial tissue. Materials and Methods.
Ondrej Dvorak +4 more
doaj +1 more source
The mismatch repair system protects against intergenerational GAA repeat instability in a Friedreich ataxia mouse model [PDF]
, 2012 Copyright @ 2012 Elsevier. The article can be accessed from the link below.This article has been made available through the Brunel Open Access Publishing Fund.Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by a ...
Al-Mahdawi, S +6 more
core +1 more source