Results 1 to 10 of about 17,115 (145)

A POLE P286R‐Mutated Hepatoid Adenocarcinoma of the Lung Showing Substantial Response to Immune Checkpoint Inhibition [PDF]

Cancer Reports
Background Hepatoid adenocarcinoma of the lung (HAL) is a rare form of lung cancer with histological and morphological properties of hepatocellular carcinoma, characterized by an aggressive course of the disease and unfavorable prognosis.
Aleksey Chernev, Alina Kaurtseva, Ruslan Abasov, Rafael Enikeev, Nina Gegelia, Gulnara Abdrakova, Natalia Usman, Alexander Druy, Grigory Raskin   +8 more
doaj   +2 more sources

Prostatic Adenosquamous Carcinoma With a Minute Squamous Component in the Initial Biopsy and Early Liver Metastasis: A Case Report [PDF]

IJU Case Rep
ABSTRACT Introduction We report a case of de novo prostatic adenosquamous carcinoma with a minute squamous component in the initial biopsy and early liver metastasis despite a marked prostate‐specific antigen response. Case Presentation A 72‐year‐old man was diagnosed with locally advanced prostate cancer with nodal and multiple bone metastases ...
Tsubouchi Y, Naiki T, Naiki‐Ito A, Unno R, Etani T, Nagai T, Morikawa T, Ishikawa D, Suzuki H, Yasui T.   +9 more
europepmc   +2 more sources

Novel MSH2 frameshift variant (c.579delG) in a patient with suspected Lynch syndrome in China [PDF]

Frontiers in Medicine
PurposeTo identify genetic variants in Chinese families with colorectal cancer.MethodsExpression of mismatch-repair proteins was assessed via immunohistochemistry in three probands. Genetic variants were identified using whole-exome sequencing. In silico
Haichun Ni, Xiufang Wang, Yi Zhu, Chengzhi He, Hengfei Li, Aiping Deng, Fei You, Juyi Li, Yi Hu   +8 more
doaj   +2 more sources

Dedifferentiation in endometrial cancer is associated with HLA-I silencing that may be restored by IFN-γ. [PDF]

J Pathol
Abstract Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low‐grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non‐Fermentable (SWI/SNF) complex protein(s).
De Leo A, Wickenberg M, Grillini M, Coadǎ CA, Praveen Kumar P, Tong A, Key J, Kim H, Kommoss F, Carey M, Fu Y, Ceccarelli C, Tallini G, LaPointe P, Köbel M, Lee CH.   +15 more
europepmc   +2 more sources

Outcomes of 'in-house' genetic testing within a specialist hereditary colorectal cancer registry. [PDF]

Colorectal Dis
Abstract Aims Approximately 5%–10% of colorectal cancer (CRC) cases are due to known Mendelian syndromes. This study aimed to report the diagnostic yield of constitutional genetic testing, alongside clinicopathological factors for hereditary CRC, within a specialised National Bowel Hospital, and outside traditional genetics referral pathways.
Srisuttayasathien M, Cuthill V, Hawkins M, Sinha A, Clark S, Latchford A, Monahan KJ.   +6 more
europepmc   +2 more sources

Hereditary ovarian cancer

Сибирский онкологический журнал, 2022
Background. Hereditary genetic mutations are a significant risk factor for malignant transformation of cells and cancer development. Hereditary genetic mutations account for 15 to 25 % of all ovarian carcinomas. Purpose of the study: to summarize data on
Kh. B. Kotiv, T. V. Gorodnova, A. P. Sokolenko, I. V. Berlev, E. N. Imyanitov   +4 more
doaj   +1 more source

A simplified two-marker immunohistochemistry strategy for Lynch syndrome screening in endometrial cancer patients [PDF]

Obstetrics & Gynecology Science, 2023
Objective To examine the efficacy of MSH6 and PMS2 immunohistochemistry (IHC) as a screening method for Lynch syndrome in endometrial cancer patients.
Ala Aiob, Yeo Rae Kim, Kidong Kim, Hyojin Kim, Yong Beom Kim, Duck Woo Kim, Jae Hong No, Soo Hyun Seo, Dong Hoon Suh, Kyoung Un Park   +9 more
doaj   +1 more source

Relationship between the expression of mismatch repair proteins and colorectal cancer with mesenteric tumor deposit

Zhongguo linchuang yanjiu, 2023
Objective To investigate the clinicopathological significance of colorectal cancer with mesenteric tumor deposit(TD) and the relationship with DNA mismatch repair(MMR) protein expression.
HUANG Ke-qiang, TANG Hua, HUANG Qiu-xia, OU Hai-ling
doaj   +1 more source

THE IMMUNOHISTOCHEMICAL EXPRESSIONS OF MISMATCH REPAIR GENES MLH1, PMS2, MSH6, MSH2 IN GASTRIC CANCER; A TISSUE MICROARRAY STUDY

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 2021
ObjectiveWe aimed to evaluate the correlation between theimmunohistochemical expressions of MLH1, PMS2,MSH6, MSH2 and clinicopathological parameters ingastric carcinoma.Matherials and MethodsImmunohistochemistry was performed on the tissuemicroarray (TMA)
Gamze Erkılınç, Nermin Karahan, Şirin Başpınar, Zümrüt Arda Kaymak, Şehnaz Evrimler   +4 more
doaj   +1 more source

Diagnostic and therapeutic challenges of glioblastoma as an initial malignancy of constitutional mismatch repair deficiency (CMMRD): two case reports and a literature review

BMC Medical Genomics, 2023
Background Constitutional mismatch repair deficiency (CMMRD) results from a biallelic germline pathogenic variant in a mismatch repair (MMR) gene. The most common CMMRD-associated malignancies are brain tumors; an accurate diagnosis is challenging when a
Shumpei Onishi, Fumiyuki Yamasaki, Kazuya Kuraoka, Akira Taguchi, Takeshi Takayasu, Kiwamu Akagi, Takao Hinoi   +6 more
doaj   +1 more source