Results 1 to 10 of about 29,501 (185)
Haseki Tıp Bülteni, 2021 Aim:Colorectal cancer (CRC) is the third most common cancer in the world. About 5-6% of all CRCs have a hereditary inheritance related with germline mutations.
Mehmet Buğrahan Düz
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Inhibition of TGM2 enhances cisplatin sensitivity in MSH2-deficient bladder cancer [PDF]
Cell Death DiscoveryMSH2 (mutS homolog 2) gene, a key component of the DNA mismatch repair system, garners significant attention for its influence on cancer progression and prognosis.
Wenjie Wei +9 more
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Immunohistochemical Expression of MSH2 and MSH6 Mismatch Repair Proteins and Their Pathological Correlations in Canine Primary Pulmonary Carcinoma [PDF]
AnimalsDNA mismatch repair (MMR) proteins have been investigated as biomarkers in human oncology, but their role in canine PPCs has not been characterized.
Alexandra Morar +6 more
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A Lynch Syndrome Family With Germline <i>MLH1</i> c.931A>G Showing Preserved Tumor MMR Immunostaining but MSI-H Status: A Case Report. [PDF]
Clin Case RepABSTRACT Lynch syndrome screening may be complicated by discordant tumor testing results. We report a family carrying the germline MLH1 c.931A>G (p.Lys311Glu) variant in which both the proband and his father had colorectal tumors with retained mismatch repair protein expression by immunohistochemistry but microsatellite instability‐high status on tumor
Cai J +6 more
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Mutators Enhance Adaptive Micro-Evolution in Pathogenic Microbes
Microorganisms, 2022 Adaptation to the changing environmental conditions experienced within a host requires genetic diversity within a microbial population. Genetic diversity arises from mutations which occur due to DNA damage from exposure to exogenous environmental ...
Kylie J. Boyce
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Zhongguo linchuang yanjiu, 2023 Objective To investigate the clinicopathological significance of colorectal cancer with mesenteric tumor deposit(TD) and the relationship with DNA mismatch repair(MMR) protein expression.
HUANG Ke-qiang, TANG Hua, HUANG Qiu-xia, OU Hai-ling
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Hesperetin effect on MLH1 and MSH2 expression on breast cancer cells BT-549
Journal of Advanced Pharmaceutical Technology & Research, 2023 Due to its genetic and phenotypic heterogeneity, breast cancer is very difficult to eliminate. The harmful consequences of conventional therapies like radiation and chemotherapy have prompted the search for organic-based alternatives. Hesperetin (HSP), a
Assim Khattab Hasan +2 more
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Frontiers in Oncology, 2021 BackgroundA large proportion of patients with Lynch syndrome (LS) have MSH2 abnormalities, but genotype-phenotype studies of MSH2 mutations in LS are still lacking.
Lin Dong +7 more
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MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice. [PDF]
PLoS Genetics, 2009 Myotonic dystrophy type 1 (DM1) is associated with one of the most highly unstable CTG*CAG repeat expansions. The formation of further repeat expansions in transgenic mice carrying expanded CTG*CAG tracts requires the mismatch repair (MMR) proteins MSH2 ...
Stéphanie Tomé +6 more
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Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice
Genes and Environment, 2021 Background Base pair mismatches in genomic DNA can result in mutagenesis, and consequently in tumorigenesis. To investigate how mismatch repair deficiency increases mutagenicity under oxidative stress, we examined the type and frequency of mutations ...
Yasunobu Aoki +6 more
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