Results 41 to 50 of about 29,501 (185)

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma

Journal of Applied Oral Science, 2013
OBJECTIVE: This study aimed to investigate the expression of the MSH2 DNA repair protein in head and neck squamous cell carcinoma (HNSCC) in order to analyze its association with clinicopathologic factors and overall survival of patients.
Camila Santos Pereira, Marcos Vinicius Macedo de Oliveira, Lucas Oliveira Barros, Gabriela Alencar Bandeira, Sergio Henrique Sousa Santos, John R. Basile, Andre Luiz Sena Guimaraes, Alfredo Mauricio Batista De Paula   +7 more
doaj   +1 more source

Artificial Intelligence in Colonoscopy Surveillance for Lynch Syndrome: Emerging Evidence, Lessons Learned From Average‐Risk Populations, and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome and is characterized by an accelerated adenoma‐carcinoma sequence, a relatively higher prevalence of flat and subtle CRC precursor lesions, and exceptionally high adenoma miss rates despite intensive colonoscopy surveillance.
Robert Hüneburg, Querijn N. E. van Bokhorst, Evelien Dekker, Jacob Nattermann   +3 more
wiley   +1 more source

Msh2 protein levels in the striata of Msh2 conditional knockout mice. A.

, 2012
Representative immunoblot of striatal lysates from five-month HdhQ111/+ mice with Msh2+/+, Msh2+/−, Msh2Δ/Δ, Msh2Δ/− and Msh2−/− genotypes probed with an anti-Msh2 antibody (upper panel).
Marina Kovalenko (136557), Ella Dragileva (136558), Raju Kucherlapati (21343), Michelle E. Ehrlich (136564), Jason St. Claire (136559), Tammy Gillis (21924), Hualing Dong (136562), Jolene R. Guide (136560), Jaclyn New (136561), Vanessa C. Wheeler (136566), Melanie H. Kucherlapati (136563), Jong-Min Lee (105338)   +11 more
core   +1 more source

MSH2 (human mutS homolog 2) [PDF]

, 2005
Review on MSH2 (human mutS homolog 2), with data on DNA, on the protein encoded, and where the gene is ...
Domingo, E, Schwartz, S Jr, S Jr Schwartz, E Domingo   +3 more
core   +1 more source

Colorectal Cancer Screening in Hereditary and Familial High‐Risk Populations: Best Practices and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related morbidity and mortality worldwide yet is largely preventable through effective screening and surveillance. While most CRC cases are sporadic, a substantial proportion occur in individuals at increased risk due to hereditary cancer syndromes or family history who require tailored
Ophir Gilad, Francesc Balaguer, Elizabeth E. Half, Kevin J. Monahan, Elena M. Stoffel, Sonia S. Kupfer   +5 more
wiley   +1 more source

MSH2 Loss in Primary Prostate Cancer.

, 2017
Purpose: Inactivation of mismatch repair (MMR) genes may predict sensitivity to immunotherapy in metastatic prostate cancers. We studied primary prostate tumors with MMR defects.
De Marzo, Angelo M, Jessica Hicks, Mario A. Eisenberger, Hicks, Jessica L, Guedes, Liana, Park, Jong Chul, Jong Chul Park, Stephanie Glavaris, William B. Isaacs, Angelo M. De Marzo, Liana B. Guedes, Glavaris, Stephanie A, Lotan, Tamara L, Eisenberger, Mario A, Fawaz Almutairi, Mirkheshti, Nooshin, Eshleman, James R, Tamara L. Lotan, Antonarakis, Emmanuel S, Michael T. Schweizer, Nooshin Mirkheshti, Emmanuel S. Antonarakis, Epstein, Jonathan I, Isaacs, William B, Schweizer, Michael T, Pritchard, Colin C, Almutairi, Fawaz, James R. Eshleman, Colin C. Pritchard, Jonathan I. Epstein   +29 more
core   +1 more source

MutS‐Homolog2 silencing generates tetraploid meiocytes in tomato (Solanum lycopersicum)

Plant Direct, 2018
MSH2 is the core protein of MutS‐homolog family involved in recognition and repair of the errors in the DNA. While other members of MutS‐homolog family reportedly regulate mitochondrial stability, meiosis, and fertility, MSH2 is believed to participate ...
Supriya Sarma, Arun Kumar Pandey, Kapil Sharma, Maruthachalam Ravi, Yellamaraju Sreelakshmi, Rameshwar Sharma   +5 more
doaj   +1 more source

Is Less More? An Update on Aspirin for Cancer Prevention in Lynch Syndrome From the Cancer Prevention Programme—CaPP

International Journal of Cancer, EarlyView.
ABSTRACT Aspirin has been used to treat pain and fever for 120 years. Its uses expanded into treating arthritis and prevention of thrombotic events. Its anti‐cancer role emerged with observational studies in the 1980's and subsequent cancer review in those treated with aspirin in cardiovascular trials.
John Burn, D. Timothy Bishop
wiley   +1 more source

Msh2-Msh6 and Msh2-Msh3 can recruit Mlh1-Pms1 and Mlh1-Mlh2 to mispaired bases.

, 2014
(A–C) Recruitment of Mlh1-Pms1 or Mlh1-Mlh2 by Msh2-Msh6 to (A) homoduplex DNA, (B) DNA containing a central TG mispair, and (C) DNA containing a central +T insertion.
Christopher S. Campbell (478470), Christopher D. Putnam (249172), Nikki Bowen (478469), Kerstin Gries (561657), Hans Hombauer (75199), Arshad Desai (205455), Richard D. Kolodner (28551), Anjana Srivatsan (255046)   +7 more
core   +1 more source