Results 21 to 30 of about 29,501 (185)

Elevated MSH2 MSH3 expression interferes with DNA metabolism in vivo

, 2023
The Msh2-Msh3 mismatch repair (MMR) complex in Saccharomyces cerevisiae recognizes and directs repair of insertion/deletion loops (IDLs) up to ∼17 nucleotides.
Medina-Rivera, Melisa, Sutton, Mark D., Kumar, Charanya, Lamb, Natalie A., Surtees, Jennifer A., Balakrishnan, Lata, Bielinsky, Anja, Phelps, Samantha, Sridharan, Madhumita, Becker, Jordan   +9 more
core   +1 more source

Msh2 blocks an alternative mechanism for non-homologous tail removal during single-strand annealing in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2009
Chromosomal translocations are frequently observed in cells exposed to agents that cause DNA double-strand breaks (DSBs), such as ionizing radiation and chemotherapeutic drugs, and are often associated with tumors in mammals.
Glenn M Manthey, Nilan Naik, Adam M Bailis   +2 more
doaj   +1 more source

MutSα mismatch repair protein stability is governed by subunit interaction, acetylation, and ubiquitination

G3: Genes, Genomes, Genetics, 2021
In eukaryotes, DNA mismatch recognition is accomplished by the highly conserved MutSα (Msh2/Msh6) and MutSβ (Msh2/Msh3) complexes.
Tim Arlow, Junwon Kim, Joanna E. Haye-Bertolozzi, Cristina Balbás Martínez, Caitlin Fay, Emma Zorensky, Mark D. Rose, Alison E. Gammie   +7 more
doaj   +1 more source

Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2014
In Saccharomyces cerevisiae, the essential mismatch repair (MMR) endonuclease Mlh1-Pms1 forms foci promoted by Msh2-Msh6 or Msh2-Msh3 in response to mispaired bases. Here we analyzed the Mlh1-Mlh2 complex, whose role in MMR has been unclear.
Christopher S Campbell, Hans Hombauer, Anjana Srivatsan, Nikki Bowen, Kerstin Gries, Arshad Desai, Christopher D Putnam, Richard D Kolodner   +7 more
doaj   +1 more source

The decrease in Rad51 and DNA ligase IV nuclear protein expression in Msh2 knockdown HC11 cells induced the low CRISPR/Cas9-mediated knock-in efficiency at the β-casein gene locus [PDF]

Animal Bioscience
Objective Successful gene editing technology is crucial in molecular biology and related fields. An essential part of an efficient knock-in system is increasing homologous recombination (HR) efficiency in the double-strand break (DSB) repair pathways ...
Ga-Yeon Kim, Man-Jong Kang
doaj   +1 more source

Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues [PDF]

, 2012
Copyright @ 2012 Bourn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
De Biase, I, Al-Mahdawi, S, De Biase Irene, Al-Mahdawi Sahar, Pinto Ricardo Mouro, Sandi, C, Pook, MA, Pinto, RM, Sahar Al-Mahdawi, Chiranjeevi Sandi, Sandi Chiranjeevi, Sanjay I Bidichandani, Bourn Rebecka L., Bidichandani, S, Irene De Biase, Bourn, RL, Ricardo Mouro Pinto, Pook Mark A., Rebecka L Bourn, Bidichandani Sanjay I., Mark A Pook   +20 more
core   +2 more sources

A Novel Splice-Site Mutation in MSH2 Is Associated With the Development of Lynch Syndrome

Frontiers in Oncology, 2020
Lynch syndrome (LS) is an inherited autosomal dominant disorder caused by germline mutations of mismatch repair (MMR) genes, including MSH2, MSH6, PMS2, and MLH1.
Juyi Li, Yuanyuan Li, Haichun Ni, Zhibin Yang, Jian Chen, Yarong Li, Sheng Ding, Xiaowan Jiang, Mengjie Wang, Li Li, Xiaoyu Lv, Xiaoyun Ruan, Qian Jiang, Zhang Lei, Yong Cheng, Juan Huang, Aiping Deng   +16 more
doaj   +1 more source

A Hereditable Mutation of MSH2 Gene Associated with Lynch Syndrome in a Five Generation Chinese Family

Cancer Management and Research, 2020
Wei-Hua Shao,1– 4,* Cheng-Yu Wang,4,5,* Lei-Yun Wang,1– 4 Fan Xiao,1– 4 De-Sheng Xiao,6 Hao Yang,4,5 Xue-Ying Long,7 Le Zhang,8 Heng-Gui Luo,9 Ji-Ye Yin,1– 4 Wei Wu4,5 1Department of Clinical Pharmacology, Xiangya Hospital ...
Shao WH, Wang CY, Wang LY, Xiao F, Xiao DS, Yang H, Long XY, Zhang L, Luo HG, Yin JY, Wu W   +10 more
doaj  

Mismatch Repair Protein MSH2 Expression and Prognosis of Colorectal Cancer Patients

The International Journal of Biological Markers, 2004
Introduction and aims The role of genetic factors in the etiology and prognosis of patients with sporadic colorectal cancer is controversial. We have therefore investigated the biological and clinicopathological influence of immunohistochemical MSH2 ...
C.G. Bernardo, J.J. Gonzílez, L. Sanz, E. Barbón, J.G. Noval, M.F. Fresno, J. Aza   +6 more
doaj   +1 more source

Mismatch repair status in Endometrioid type of Endometrial Carcinoma: association with clinicopathological parameters [PDF]

Egyptian Journal of Cancer and Biomedical Research, 2020
Introduction: Endometrial carcinoma [EC], particularly the most predominant endometrioid type [EEC] is a major contributor to cancer burden globally, and its molecular classification has gained much importance recently. Aim: This study aimed to determine
Asmaa Eid, noha elanwar, Shorouk Mwafy
doaj   +1 more source