Results 11 to 20 of about 29,501 (185)

Càncer colorectal hereditari: Aplicacions diagnòstiques de l'estudi de la dosi dels gens APC, MLH1 i MSH2 [PDF]

, 2009
[cat] Les síndromes de càncer colorectal (CCR) hereditari representen entre un 3% i un 5% de tots els casos de CCR i inclouen tots aquells individus amb un elevat grau d'agregació familiar.
Castellsagué Torrents, Ester
core   +6 more sources

Mutator phenotype in Msh2-deficient murine embryonic fibroblasts

, 1997
Embryonic fibroblast cell lines were established from mice deficient, heterozygous, or proficient for Msh2, one of the three known DNA mismatch repair genes involved in hereditary nonpolyposis colon cancer (HNPCC).
Meuth, Mark, Reitmair, Armin H., Hill, Richard P., Mak, Tak W., Benchimol, Samuel, Fishel, Richard, Ganesh, Anil, Jang, Anne, Peacock, James, Bristow, Robert G.; id_orcid, Risley, Robert, Wilson, Teresa   +11 more
core   +11 more sources

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

MSH2 stimulates interfering and inhibits non-interfering crossovers in response to genetic polymorphism

Nature Communications, 2023
Meiotic crossovers can be formed through the interfering pathway, in which one crossover prevents another from forming nearby, or by an independent non-interfering pathway.
Julia Dluzewska, Wojciech Dziegielewski, Maja Szymanska-Lejman, Monika Gazecka, Ian R. Henderson, James D. Higgins, Piotr A. Ziolkowski   +6 more
doaj   +1 more source

MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites. [PDF]

PLoS ONE, 2010
Mismatch repair of AID-generated dU:G mispairs is critical for class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The generation of a previously unavailable Msh2(-/-)Msh6(-/-) mouse has for the first time allowed us to examine ...
Sergio Roa, Ziqiang Li, Jonathan U Peled, Chunfang Zhao, Winfried Edelmann, Matthew D Scharff   +5 more
doaj   +1 more source

Restoration of mismatch repair functions in human cell line Nalm-6, which has high efficiency for gene targeting. [PDF]

PLoS ONE, 2013
Gene targeting is a powerful approach in reverse genetics. The approach has been hampered in most of human cell lines, however, by the poor targeting efficiency.
Tetsuya Suzuki, Akiko Ukai, Masamitsu Honma, Noritaka Adachi, Takehiko Nohmi   +4 more
doaj   +1 more source

Andrias davidianus Ranavirus (ADRV) Genome Replicate Efficiently by Engaging Cellular Mismatch Repair Protein MSH2

Viruses, 2022
As nucleocytoplasmic large DNA viruses, replication of ranaviruses (genus Ranavirus, family Iridoviridae) involves a series of viral and host proteins.
Fei Ke, Renbao Wang, Zihao Wang, Qiya Zhang   +3 more
doaj   +1 more source

Combined MLH1/MSH2/MSH6 assessment by IHC and RT-qPCR: Differential expression analysis and incremental value for pathological risk stratification in colorectal cancer [PDF]

Journal of Medical Biochemistry
Background: Mismatch repair (MMR) status is routinely assessed in colorectal cancer (CRC), yet the laboratory value of combining multiple MMR targets across platforms for risk stratification requires verification under real-world testing conditions. This
Zhang Yi, Li Xin, Ran Jing, Zuo Ningchuan   +3 more
doaj   +1 more source

Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: Genetic reclassification and correlation with clinical features [PDF]

, 2004
Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly ...
Gross, M., Lohse, P., Muders, M., Müller-Koch, Y., Daum, J., Mussack, T., Baretton, G., Kopp, R., Schiemann, Uwe, Holinski-Feder, E.   +9 more
core   +1 more source

CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSα/ATM-p73 axis in bladder cancer

Molecular Cancer, 2021
Background Cisplatin (CDDP) has become a standard-of-care treatment for muscle-invasive bladder cancer (MIBC), while chemoresistance remains a major challenge. Accumulating evidence indicates that circular RNAs (circRNAs) are discrete functional entities.
Hui Zhang, Xingyuan Xiao, Wenjie Wei, Chao Huang, Miao Wang, Liang Wang, Yuanqiao He, Jiayin Sun, Yangkai Jiang, Guosong Jiang, Xiaoping Zhang   +10 more
doaj   +1 more source