Results 31 to 40 of about 33,127 (201)

Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer. [PDF]

PLoS ONE, 2010
We previously identified an association between a mismatch repair gene, MLH1, promoter SNP (rs1800734) and microsatellite unstable (MSI-H) colorectal cancers (CRCs) in two samples.
Miralem Mrkonjic, Nicole M Roslin, Celia M Greenwood, Stavroula Raptis, Aaron Pollett, Peter W Laird, Vaijayanti V Pethe, Theodore Chiang, Darshana Daftary, Elizabeth Dicks, Stephen N Thibodeau, Steven Gallinger, Patrick S Parfrey, H Banfield Younghusband, John D Potter, Thomas J Hudson, John R McLaughlin, Roger C Green, Brent W Zanke, Polly A Newcomb, Andrew D Paterson, Bharati Bapat   +21 more
doaj   +1 more source

BRAF and MLH1 Analysis Algorithm for the Evaluation of Lynch Syndrome Risk in Colorectal Carcinoma Patients: Evidence-Based Data from the Analysis of 100 Consecutive Cases

Journal of Molecular Pathology, 2022
Several causes may lead to CRC, either extrinsic (sporadic forms) or genetic (hereditary forms), such as Lynch syndrome (LS). Most sporadic deficient mismatch repair (dMMR) CRC cases are characterized by the methylation of the MLH1 promoter gene and/or ...
Thais Maloberti, Antonio De Leo, Viviana Sanza, Lidia Merlo, Michela Visani, Giorgia Acquaviva, Sara Coluccelli, Annalisa Altimari, Elisa Gruppioni, Stefano Zagnoni, Daniela Turchetti, Sara Miccoli, Michelangelo Fiorentino, Antonietta D’Errico, Dario de Biase, Giovanni Tallini   +15 more
doaj   +1 more source

MLH1 mutation.

, 2022
MLH1 mutation.
Vania Myralda Giamour Marbun (12884117), Toar Jean Maurice Lalisang (12884120), Linda Erlina (9914846)   +2 more
core   +1 more source

MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway

BMC Cancer, 2018
Background MLH1 plays a critical role in maintaining the fidelity of DNA replication, and defects in human MLH1 have been reported. However, the role of MLH1 in endometrial carcinoma has not been fully investigated.
Yue Li, Shihong Zhang, Yuanjian Wang, Jin Peng, Fang Fang, Xingsheng Yang   +5 more
doaj   +1 more source

MLH1–93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation

BMC Cancer, 2018
Background Sessile serrated adenomas with BRAF mutation progress rapidly to cancer following the development of dysplasia (SSAD). Approximately 75% of SSADs methylate the mismatch repair gene MLH1, develop mismatch repair deficiency and the resultant ...
Lochlan J. Fennell, Saara Jamieson, Diane McKeone, Tracie Corish, Megan Rohdmann, Tori Furner, Mark Bettington, Cheng Liu, Futoshi Kawamata, Catherine Bond, Jolieke Van De Pols, Barbara Leggett, Vicki Whitehall   +12 more
doaj   +1 more source

Association between colorectal cancer, the frequency of Bacteroides fragilis, and the level of mismatch repair genes expression in the biopsy samples of Iranian patients

BMC Gastroenterology
Background Deficient DNA mismatch repair (MMR) can cause microsatellite instability (MSI) and is more common in colorectal cancer (CRC) patients.
Nooshin Nazarinejad, Bahareh Hajikhani, Amir Abbas Vaezi, Farzaneh Firoozeh, Fatemeh Sameni, Somayeh Yaslianifard, Mehdi Goudarzi, Masoud Dadashi   +7 more
doaj   +1 more source

MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her‐2/PI3K/AKT Signaling

Advanced Science, 2020
The rapid onset of resistance to cetuximab (CTX) limits its clinical utility in colorectal cancer (CRC) patients. This study aims to understand a potential role of mismatch repair gene mutL homolog 1 (MLH1) in CTX response. Functional analysis of MLH1 in
Ying Han, Yinghui Peng, Yaojie Fu, Changjing Cai, Cao Guo, Shanshan Liu, Yiyi Li, Yihong Chen, Edward Shen, Kexin Long, Xinwen Wang, Jian Yu, Hong Shen, Shan Zeng   +13 more
doaj   +1 more source

CDK2 phosphorylates full-length MLH1.

, 2023
(A) CDK2/cyclin A2 kinase assay directed against GST-tagged fusion MLH1 (all lanes). Increasing amounts of GST-MLH1 are used in lanes 1–3 as indicated.
Kajal Biswas (14833686), Nathan Palmer (264897), Philipp Kaldis (3122793), S. Zakiah A. Talib (9536989), Christine M. F. Goh (9536992), Shyam K. Sharan (3142788)   +5 more
core   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Lynch syndrome with MLH1 germline variant in an extended family: a case report

Open Life Sciences
Lynch syndrome (LS) is an inherited cancer predisposition syndrome associated with an increased risk of several malignancies, particularly colorectal cancer (CRC). The diagnosis of LS is typically based on family history and confirmed by genetic testing,
Duan Zhipei, Hu Chengru, Cao Tinghua, Chen Chao, Li Yan   +4 more
doaj   +1 more source