Results 51 to 60 of about 33,127 (201)

MLH1 immunolocalization.

, 2014
Immunolocalization of MLH1 at diakinesis is shown (A) in wild type and (B) in Atpss1-1. (C, D). Scatter plot of MLH1 foci number per cell at diplotene and diakinesis.
Yann Duroc (646057), Christine Horlow (106244), Aurélie Hurel (646059), Liudmila Chelysheva (35344), Laurence Cromer (149035), Afef Lemhemdi (149137), Maria Cuacos (646060), Raphael Mercier (35349), Susan J. Armstrong (185516), Cécile Larchevêque (646058)   +9 more
core   +1 more source

Colorectal Cancer Screening in Hereditary and Familial High‐Risk Populations: Best Practices and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related morbidity and mortality worldwide yet is largely preventable through effective screening and surveillance. While most CRC cases are sporadic, a substantial proportion occur in individuals at increased risk due to hereditary cancer syndromes or family history who require tailored
Ophir Gilad, Francesc Balaguer, Elizabeth E. Half, Kevin J. Monahan, Elena M. Stoffel, Sonia S. Kupfer   +5 more
wiley   +1 more source

Modulation of transcription factor binding and epigenetic regulation of the MLH1 CpG island and shore by polymorphism rs1800734 in colorectal cancer

Epigenetics, 2017
The MLH1 promoter polymorphism rs1800734 is associated with MLH1 CpG island hypermethylation and expression loss in colorectal cancer (CRC). Conversely, variant rs1800734 is associated with MLH1 shore, but not island, hypomethylation in peripheral blood ...
Andrea J. Savio, Bharati Bapat
doaj   +1 more source

Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway. [PDF]

PLoS Genetics, 2013
Lynch syndrome (hereditary nonpolypsis colorectal cancer or HNPCC) is a common cancer predisposition syndrome. Predisposition to cancer in this syndrome results from increased accumulation of mutations due to defective mismatch repair (MMR) caused by a ...
Catherine E Smith, Marc L Mendillo, Nikki Bowen, Hans Hombauer, Christopher S Campbell, Arshad Desai, Christopher D Putnam, Richard D Kolodner   +7 more
doaj   +1 more source

Is Less More? An Update on Aspirin for Cancer Prevention in Lynch Syndrome From the Cancer Prevention Programme—CaPP

International Journal of Cancer, EarlyView.
ABSTRACT Aspirin has been used to treat pain and fever for 120 years. Its uses expanded into treating arthritis and prevention of thrombotic events. Its anti‐cancer role emerged with observational studies in the 1980's and subsequent cancer review in those treated with aspirin in cardiovascular trials.
John Burn, D. Timothy Bishop
wiley   +1 more source

MLH1 deficiency leads to deregulated mitochondrial metabolism [PDF]

, 2019
The DNA mismatch repair (MMR) pathway is responsible for the repair of base–base mismatches and insertion/deletion loops that arise during DNA replication.
Chelala, C, Cucchi, D, Suraweera, N, Silver, A, Gay, L, Szabadkai, G, Martin, SA, Wang, J, Freitas, MO, Yao, Z, Williams, M, Rashid, S, McDonald, SAC, Bridge, G   +13 more
core   +2 more sources

MLH1 Gene Expression and Pathologic Factors in Iranian Patients with Colorectal Cancer

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2020
Background and Objectives: MutL homolog (MLH1) is a key component of heterodimeric complex MutLα, which recognizes and repairs base-base mismatches or insertion/deletion loops that arise from nucleotide misincorporation.
Ahdieh Hosseini Anvari, Shahla Mohammad Ganji, Tahereh Ahdieh Hosseini Komeili Movahhed   +2 more
doaj  

MLH1 promoter methylation frequency in colorectal cancer patients and related clinicopathological and molecular features.

PLoS ONE, 2013
PurposeTo describe the frequency of MLH1 promoter methylation in colorectal cancer (CRC); to explore the associations between MLH1 promoter methylation and clinicopathological and molecular factors using a systematic review and meta-analysis.MethodsA ...
Xia Li, Xiaoping Yao, Yibaina Wang, Fulan Hu, Fan Wang, Liying Jiang, Yupeng Liu, Da Wang, Guizhi Sun, Yashuang Zhao   +9 more
doaj   +1 more source

Msh2-Msh6 and Msh2-Msh3 can recruit Mlh1-Pms1 and Mlh1-Mlh2 to mispaired bases.

, 2014
(A–C) Recruitment of Mlh1-Pms1 or Mlh1-Mlh2 by Msh2-Msh6 to (A) homoduplex DNA, (B) DNA containing a central TG mispair, and (C) DNA containing a central +T insertion.
Christopher S. Campbell (478470), Christopher D. Putnam (249172), Nikki Bowen (478469), Kerstin Gries (561657), Hans Hombauer (75199), Arshad Desai (205455), Richard D. Kolodner (28551), Anjana Srivatsan (255046)   +7 more
core   +1 more source

Urinary and Faecal Amino‐Acids as Biomarkers for Colorectal Neoplasia in Lynch Syndrome—A Prospective Longitudinal Study

International Journal of Cancer, EarlyView.
ABSTRACT In Lynch syndrome, colonoscopy surveillance for colorectal cancer (CRC) is burdensome and post‐colonoscopy CRCs still occur. Unlike the faecal immunochemical test (FIT), gut metabolomic alterations including amino‐acids have shown potential as non‐invasive biomarkers for detecting both advanced and non‐advanced sporadic colorectal neoplasia ...
Roza C. M. Opperman, Elsa L. S. A. van Liere, Animesh Acharjee, Sudip Mondal, Eduard A. Struys, Andreas Antoniadis, Jasmijn E. B. de Boer, Shivra R. Siriram, Abdellatif Bakkali, Sofie Bosch, Maarten A. J. M. Jacobs, Jan Jacob Koornstra, Johan P. Kuijvenhoven, Monique E. van Leerdam, Manon C. W. Spaander, Tim G. J. de Meij, Evelien Dekker, Dewkoemar Ramsoekh, Nanne K. H. de Boer   +18 more
wiley   +1 more source