Results 61 to 70 of about 33,127 (201)

Impact of ovarian preservation on survival for premenopausal women with early‐stage endometrial carcinoma: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Up to 14% of women with early‐stage endometrial carcinoma (EEC) are diagnosed before menopause. Although ovarian preservation (OP) within surgical staging might avoid surgical menopause, its rate remains low in clinical practice, probably because the impact of OP on survival outcomes is unclear.
Antonio Raffone, Diego Raimondo, Daniele Neola, Manuela Maletta, Marisol Doglioli, Antonio Travaglino, Carlo Ronsini, Maria Giovanna Vastarella, Stefano Ferla, Francesco Cosentino, Pasquale De Franciscis, Renato Seracchioli, Luigi Cobellis   +12 more
wiley   +1 more source

Analysis of SPTAN1 expression in MLH1-deficient and MLH1-proficient CRCs.

, 2019
Sample immunohistochemistry images of an MLH1-deficient CRC show (A) loss of MLH1, (B) moderate SPTAN1 expression in the adjacent normal mucosa, and (C) a clear reduction of SPTAN1 expression in the tumor. The sporadic CRC below shows (D) intense nuclear
Dimitra Bon (797699), Anne Ackermann (6443975), Guido Plotz (22851), Peter Wild (18726), Martin-Leo Hansmann (260067), Angela Brieger (333158), Katrin Bankov (4025753), Nicolaus Friedrichs (6443978), Eva Herrmann (139197), Christopher Schrecker (5754143), Stefan Zeuzem (22856)   +10 more
core   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair. [PDF]

PLoS Genetics, 2008
DNA interstrand crosslinks (ICLs) are among the most toxic types of damage to a cell. For this reason, many ICL-inducing agents are effective therapeutic agents.
Qi Wu, Karen M Vasquez
doaj   +1 more source

Association between the MLH1 gene and longevity

, 2006
Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which ...
Park, Sang Chul, Yi, Sang Mi, Lee, Seung Yeon, Choi, Yoon-Ho, Kang, Heun Soo, Song, Yeong Wook, Kim, Dong Jo   +6 more
core   +1 more source

Bipolar Androgen Therapy as a Potential Mechanistic Bridge to Enhance PARP Inhibitor Efficacy in Prostate Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Prostate cancer remains a leading cause of cancer‐related mortality, largely driven by progression to metastatic castration‐resistant prostate cancer (mCRPC). Although poly(ADP‐ribose) polymerase inhibitors (PARPis) have improved outcomes in patients with homologous recombination repair (HRR) alterations, particularly in BRCA2‐mutated disease,
Jhen‐Hao Jhan, Jiun‐Hung Geng, Hung‐Lung Ke, Shu‐Pin Huang, Li Jia   +4 more
wiley   +1 more source

Epigenetic differences in the tumor suppressor genes MLH1 and p16INK4a between Nepalese and Swedish patients with colorectal cancer

Innovative Surgical Sciences
Colorectal cancer (CRC) is one of the most prevalent cancer types worldwide, exhibiting significant variance in incidence rates across different ethnicities and geographical regions.
Ghimire Bikal, Kurlberg Göran, Falk Peter, Singh Yogendra, Wettergren Yvonne   +4 more
doaj   +1 more source

Dedifferentiation in endometrial cancer is associated with HLA‐I silencing that may be restored by IFN‐γ

The Journal of Pathology, EarlyView.
Abstract Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low‐grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non‐Fermentable (SWI/SNF) complex protein(s).
Antonio De Leo, Madison Wickenberg, Marco Grillini, Camelia Alexandra Coadǎ, Pooja Praveen Kumar, Annie Tong, James Key, Hannah Kim, Felix Kommoss, Mark Carey, Yangxin Fu, Claudio Ceccarelli, Giovanni Tallini, Paul LaPointe, Martin Köbel, Cheng‐Han Lee   +15 more
wiley   +1 more source

Spreading of Alu methylation to the promoter of the MLH1 gene in gastrointestinal cancer. [PDF]

PLoS ONE, 2011
The highly repetitive Alu retroelements are regarded as methylation centres in the genome. Methylation in the gene promoters could be spreading from them.
Xiyin Wang, Jing Fan, Dong Liu, Siqing Fu, Sigurdur Ingvarsson, Huiping Chen   +5 more
doaj   +1 more source

Case Report: Medullary carcinoma of the pancreas with MLH1 promoter hypermethylation, induced deficient mismatch repair, successfully treated with an immune checkpoint inhibitor [PDF]

We report the case of a 75-year-old woman with a pancreatic body mass. Pathological findings from endoscopic ultrasonography-guided fine-needle aspiration revealed medullary carcinoma of the pancreas (MCP).
Gabata, Toshifumi, Takayuki Yoshino, Nakamura, Yoshiaki, Hiroyuki Sakaguchi, Miwa, Kazuhiro, Yamashita, Kaname, 24695, Kaname Yamashita, Seiji Yano, Notohara, Kenji, Watanabe, Atsushi, Miyake, Kunio, Sato, Shigeki, Fujisawa, Takao, Fumihito Toshima, Kazuhiro Miwa, Inoue, Dai, Takao Fujisawa, ミヤケ, クニオ, Ikeda, Hiroko, 60550712, Kenji Notohara, Kotani, Hiroshi, Sakaguchi, Hiroyuki, Hiroko Ikeda, Dai Inoue, Shigeki Sato, Toshima, Fumihito, Hiroshi Kotani, Nishiyama, Akihiro, Akihiro Nishiyama, Ohtsubo, Koushiro, Kunio Miyake, Atsushi Watanabe, Takeuchi, Shinji, Shinji Takeuchi, Yoshino, Takayuki, Yano, Seiji, Koushiro Ohtsubo, Toshifumi Gabata, 三宅, 邦夫, Yoshiaki Nakamura   +41 more
core   +1 more source