Results 41 to 50 of about 33,127 (201)

BRD4 expression against MLH1.

, 2022
The loss of MLH1 expression is associated with low BRD4 H-scores. (TIFF)
Biwei Cao (8487582), Ozlen Saglam (727336), Gokce A. Toruner (7364117), Xuefeng Wang (113961), Jose R. Conejo-Garcia (6055289)   +4 more
core   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Living at genetic risk: The patient experience of Lynch syndrome

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents, Georgina Hoffmann, Kelly Kohut   +2 more
wiley   +1 more source

Coordinated and Independent Roles for MLH Subunits in DNA Repair

Cells, 2021
The MutL family of DNA mismatch repair proteins (MMR) acts to maintain genomic integrity in somatic and meiotic cells. In baker’s yeast, the MutL homolog (MLH) MMR proteins form three heterodimeric complexes, MLH1-PMS1, MLH1-MLH2, and MLH1-MLH3.
Gianno Pannafino, Eric Alani
doaj   +1 more source

Comparison of SPTAN1 in MLH1-proficient vs. MLH1-deficient CRCs.

, 2019
The intensity of protein expression was determined by immunohistochemistry to compare SPTAN1 expression in CRC tissue from 189 patients. SPTAN1 expression of (A) MLH1-proficient tumors and (B) MLH1-deficient tumors was compared with the surrounding ...
Dimitra Bon (797699), Anne Ackermann (6443975), Guido Plotz (22851), Peter Wild (18726), Martin-Leo Hansmann (260067), Angela Brieger (333158), Katrin Bankov (4025753), Nicolaus Friedrichs (6443978), Eva Herrmann (139197), Christopher Schrecker (5754143), Stefan Zeuzem (22856)   +10 more
core   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

QuPath Algorithm Accurately Identifies MLH1-Deficient Inflammatory Bowel Disease-Associated Colorectal Cancers in a Tissue Microarray

Diagnostics, 2023
Current methods for analysing immunohistochemistry are labour-intensive and often confounded by inter-observer variability. Analysis is time consuming when identifying small clinically important cohorts within larger samples.
Ross J. Porter, Shahida Din, Peter Bankhead, Anca Oniscu, Mark J. Arends   +4 more
doaj   +1 more source

Induction of MLH1 shRNA decreases MLH1 protein levels.

, 2013
MLH1 protein levels in NCI-H23 subclones induced for the MLH1 928 shRNA were compared to MLH1 protein levels in the NCI-H23 parental cells (H23). Protein lysates were analyzed by SDS-PAGE and immunoblotting for the MLH1 and MSH2 protein levels. GAPDH was
Julie M. Bailis (477608), Jacqueline K. Barton (477612), Ilan R. Kirsch (477613), Alexis C. Komor (477611), Jesse L. Gurgel (477610), Marcia L. Gordon (477609)   +5 more
core   +1 more source

Artificial Intelligence in Colonoscopy Surveillance for Lynch Syndrome: Emerging Evidence, Lessons Learned From Average‐Risk Populations, and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome and is characterized by an accelerated adenoma‐carcinoma sequence, a relatively higher prevalence of flat and subtle CRC precursor lesions, and exceptionally high adenoma miss rates despite intensive colonoscopy surveillance.
Robert Hüneburg, Querijn N. E. van Bokhorst, Evelien Dekker, Jacob Nattermann   +3 more
wiley   +1 more source

Haploinsufficiency by minute MutL homolog 1 promoter DNA methylation may represent unique phenotypes of microsatellite instability-gastric carcinogenesis.

PLoS ONE, 2021
Promoter DNA methylation of MutL homolog 1 (MLH1) is considered to play a causative role in microsatellite instability (MSI) carcinogenesis in primary gastric cancer, and a high MSI status is associated with treatment sensitivity to human cancers ...
Hiroki Harada, Yusuke Nie, Ippeita Araki, Takafumi Soeno, Motohiro Chuman, Marie Washio, Mikiko Sakuraya, Hideki Ushiku, Masahiro Niihara, Kei Hosoda, Yusuke Kumamoto, Takeshi Naitoh, Takafumi Sangai, Naoki Hiki, Keishi Yamashita   +14 more
doaj   +1 more source