Results 11 to 20 of about 44,743 (233)
Selection of patients with germline MLH1 mutated Lynch syndrome by determination of MLH1 methylation and BRAF mutation [PDF]
Familial Cancer, 2018 Lynch syndrome is one of the most common hereditary colorectal cancer (CRC) syndrome and is caused by germline mutations of MLH1, MSH2 and more rarely MSH6, PMS2, MLH3 genes.
Benhattar, Jean +4 more
core +5 more sources
Isolated MLH1 Loss by Immunohistochemistry Because of Benign Germline MLH1 Polymorphisms
JCO Precision Oncology, 2022 PURPOSE Mismatch repair (MMR) immunohistochemistry (IHC) is frequently used to inform prognosis, select (immuno-)therapy, and identify patients for heritable cancer syndrome testing. However, false-negative and false-positive MMR IHC interpretations have been described.
Dustin E. Bosch +6 more
openaire +2 more sources
Вавиловский журнал генетики и селекции, 2021 Benefits and costs of meiotic recombination are a matter of discussion. Because recombination breaks allele combinations already tested by natural selection and generates new ones of unpredictable fitness, a high recombination rate is generally ...
L. P. Malinovskaya +8 more
doaj +1 more source
Hereditary Cancer in Clinical Practice, 2008 DNA testing is recommended in families fulfilling at least "suspected HNPCC" criteria. After exclusion of FAP (characteristic FAP features include polyposis, congenital hypertrophy of the retinal pigment epithelium, cysts and osteomata of bones of the maxilla and mandible, desmoid tumours), immunohistochemical analyses (IHC) of MLH1, MSH2 and MSH6 ...
Kurzawski Grzegorz +2 more
openaire +3 more sources
Acta Societatis Botanicorum Poloniae, 2020 The Hepatica section Angulosa consists of mainly tetraploid (2n = 28) species that are distributed disjunctly throughout Eurasia. Karyological evidence proves the hybrid origin of the polyploid species of this section. Hepatica transsilvanica is a member
Levente Laczkó, Gábor Sramkó
doaj +1 more source
CTGF and MLH1 Gene Expression Levels in Colorectal Cancer Tumor Tissues and Adjacent Normal Tissues in Patients in Golestan Province [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: Colorectal cancer is the third most common type of cancer in terms of incidence and the second most common cause of cancer-related death worldwide.
Amin Lotfvarzi, Farkhondeh Nemati
doaj
BJS (British Journal of Surgery), EarlyView., 2020 Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä +18 more
wiley +1 more source
Micronucleus-specific histone H1 is required for micronuclear chromosome integrity in Tetrahymena thermophila. [PDF]
PLoS ONE, 2017 Histone H1 molecules play a key role in establishing and maintaining higher order chromatin structures. They can bind to linker DNA entering and exiting the nucleosome and regulate transcriptional activity.
Juxia Qiao, Jing Xu, Tao Bo, Wei Wang
doaj +1 more source
DNA Repair, 2021 Tumors of Lynch syndrome (LS) patients display high levels of microsatellite instability (MSI), which results from complete loss of DNA mismatch repair (MMR), in line with Knudson's two-hit hypothesis. Why some organs, in particular those of the gastrointestinal (GI) tract, are prone to tumorigenesis in LS remains unknown.
Kul S. Shrestha +3 more
openaire +3 more sources
High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast. [PDF]
, 2017 In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Dominska, Margaret +3 more
core +3 more sources