Results 41 to 50 of about 5,093 (138)

Changes in protein composition of meiotic nodules during mammalian meiosis [PDF]

, 1998
Homologous chromosome synapsis and meiotic recombination are facilitated by several meiosis-specific structures: the synaptonemal complex (SC), and two types of meiotic nodules: (1) early meiotic nodules (MNs), also called zygotene nodules or early ...
Hoekstra, M.F., Plug, A.W., Boer, P., de, de Boer, P., Keegan, K.S., Peters, A.H.F.M., Ashley, T.   +6 more
core  

Diagnosis and functional prediction of microbial markers in tumor tissues of sporadic colorectal cancer patients associated with the MLH1 protein phenotype [PDF]

, 2023
ObjectiveMost patients with sporadic colorectal cancer (SCRC) develop microsatellite instability because of defects in mismatch repair (MMR). Moreover, the gut microbiome plays a vital role in the pathogenesis of SCRC.
Ying He, Zongmin Li, Yuying Zhang, Wu, Youtian, Lijing Bai, Ping Jiang, Jiang, Ping, Ying Huang, Bai, Lijing, Li, Zongmin, He, Ying, Yingying Liu, Youtian Wu, Anchao Zhu, Liu, Yingying, Zhang, Yuying, Huang, Ying, Zhu, Anchao   +17 more
core   +1 more source

Incidental Colorectal Adenomas in Adolescents: Clinical Management, Genetic Evaluation, and Surveillance

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1743-1750, June 2026.
Adolescents with incidental colorectal adenomas require age‐conscious management balancing referral for genetic counseling with evidence‐based surveillance. This narrative review proposes a pragmatic clinical algorithm integrating adenoma characteristics, hereditary risk assessment, and guideline‐concordant follow‐up to support individualized ...
Brett J. Hoskins, Shlomi Cohen, Colleen B. Flahive, Isabel Rojas, Aparajita Singh, Thomas M. Attard   +5 more
wiley   +1 more source

Multicenter Phase II Trial of Temozolomide in Mycosis Fungoides/Sézary Syndrome: Correlation with O6-Methylguanine-DNA Methyltransferase and Mismatch Repair Proteins [PDF]

, 2011
Purpose: Temozolomide (TMZ) is an oral derivative of dacarbazine that induces DNA damage by methylating nucleotide bases. Resistance has been associated with high levels of O6-methylguanine-DNA methyltransferase (MGMT). Malignant CD4+ T cells of patients
Francine Foss, Alfred Rademaker, M. Eileen Dolan, Joseph Baron, Daniel B. Yarosh, Timothy M. Kuzel, Christiane Querfeld, David S. Pezen, Steven T. Rosen, Joan Guitart   +9 more
core   +1 more source

Comparison of Microsatellite Instability (MSI) and Microsatellite Stable (MSS) Invasive Breast Carcinoma Cases In Terms Of Neoadjuvant Chemotherapy Response, ER/PR Status, CerbB2, and Ki-67 [PDF]

Introduction: Microsatellite instability (MSI) is a well-established biomarker in certain malignancies; however, its prognostic and predictive role in breast cancer remains unclear. This study aimed to compare invasive breast carcinoma cases with MSI and
Selçuk Cin, Özgecan Gündoğar, Canan Kelten Talu, Merve Cin, Sibel Bektaş, Emine Yıldırım   +5 more
core   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

The Aberrant Activation of NLRP3 in Microsatellites Stability Colon Cancer Promotes M2 Macrophage Polarization Based on the TCGA Database and Tissue Microarray Analysis

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Microsatellites stability (MSS) colon cancer patients exhibit a significant suppressive immune status, and the functional status of tumor NLRP3 immunosomes plays an important role in regulating the tumor immune microenvironment, but whether they are involved in the regulation of immunosuppression in MSS patients is unclear ...
Li Lu, Menglin Wu, Xunzhen Jiang, Tong Liu, Weihua Fu, Weidong Li, Xue Li, Zhicheng Zhao   +7 more
wiley   +1 more source

Exploring the Key Role of Nanotechnology on Intratumoral Microbiome Modulation for Cancer Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
The review provides a comprehensive analysis of microbiome‐mediated oncogenic mechanisms in various cancers, emphasizing the unique therapeutic strategies facilitated by nanotechnology. It aims to fill this gap by systematically reviewing nanotechnology‐driven strategies for microbiome elimination, with a focus on their ability to improve the cold TME ...
Yumei Gan, Yan Zhang, Xia Dong, Feng Lv
wiley   +1 more source

Association Between Microsatellite Instability Status, Clinicopathological Features and Mitochondrial DNA Amplification in Patients With Colorectal Cancer [PDF]

The relationship between BRAF-V600E mutations, mitochondrial DNA amplification and microsatellite instability-high (MSI-H) in colorectal cancer (CRC) has yet to be fully elucidated.
Chen, Xi, Lu, Junmi, Tong, Zhongyi, Tan, Hong, Guo, Tao   +4 more
core   +2 more sources

Leucine modulates the IPEC-J2 cell proteome associated with cell proliferation, metabolism and phagocytosis [PDF]

, 2018
Leucine can affect intestinal protein expressions, and improve mucosal immune function. However, little study has been conducted to determine the change of protein component by leucine treatment in intestine epithelial cells.
Junqiu Luo, Xiangbing Mao, Jun He, Daiwen Chen, Man Ren, Yuheng Luo, Hui Sun, Bing Yu, Lianqiang Che, Jianping Wang   +9 more
core   +1 more source