Results 61 to 70 of about 32,331,402 (154)

Structure of the MutL$\alpha$ C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site.

, 2013
International audienceMismatch-repair factors have a prominent role in surveying eukaryotic DNA-replication fidelity and in ensuring correct meiotic recombination. These functions depend on MutL-homolog heterodimers with Mlh1.
Le Du, Marie-Hélene, Pierre Legrand, Bernard Gilquin, Boiteux, Serge, Emeric Gueneau, Márquez, Josan A, Gondry, Muriel, Moutiez, Mireille, Carine Tellier-Lebegue, Mireille Moutiez, Josan A Márquez, Legrand, Pierre, Dherin, Claudine, Cathy Quemener, Quemener, Cathy, Londino, Floriana, Bonnesoeur, Pierre, Tellier-Lebegue, Carine, Gilquin, Bernard, Muriel Gondry, Serge Boiteux, Gueneau, Emeric, Pierre Bonnesoeur, Floriana Londino, Charbonnier, Jean-Baptiste, Claudine Dherin, Marie-Hélene Le Du, Jean-Baptiste Charbonnier   +27 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Downregulation of SPTAN1 is related to MLH1 deficiency and metastasis in colorectal cancer.

PLoS ONE, 2019
IntroductionColorectal cancers (CRCs) deficient in the DNA mismatch repair protein MutL homolog 1 (MLH1) display distinct clinicopathological features and require a different therapeutic approach compared to CRCs with MLH1 proficiency.
Anne Ackermann, Christopher Schrecker, Dimitra Bon, Nicolaus Friedrichs, Katrin Bankov, Peter Wild, Guido Plotz, Stefan Zeuzem, Eva Herrmann, Martin-Leo Hansmann, Angela Brieger   +10 more
doaj   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

CHARACTERIZATION OF MUTL-MEDIATED PROTEIN INTERACTIONS IN DNA MISMATCH REPAIR [PDF]

, 2014
DNA encodes the genetic information of the cell, therefore, every single living organism has a precise DNA damage response mechanism to safeguard DNA integrity.
Pillon, Monica
core   +1 more source

The Tumor Immune Microenvironment in Endometrial Cancer: Composition, Molecular Subtypes, and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Endometrial cancer (EC), a major gynecologic malignancy and a representative “cold tumor”, exhibits a tumor immune microenvironment (TIME) influenced by a broad range of cellular and molecular elements, immunosuppressive signals, and pathways of immune evasion.
Jingxuan Ye, Yashi Shi, Alexander Mustea, Xiaodan Mao, Pengming Sun   +4 more
wiley   +1 more source

ASCL1 (achaete-scute homolog 1 or achaete-scute complex homolog 1) [PDF]

, 2008
Review on ASCL1 (achaete-scute homolog 1 or achaete-scute complex homolog 1), with data on DNA, on the protein encoded, and where the gene is ...
Ladha, JS, Rao, MRS
core   +1 more source

Adaptive Laboratory Evolution Unlocks Membrane Permeability as a Key Limitation in Long‐Chain Alcohol Metabolism by Pseudomonas putida KT2440

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
Pseudomonas putida KT2440 grows on polyethylene‐derived long‐chain alcohols (C16OH, C20OH) as sole carbon sources. Adaptive laboratory evolution rapidly increases growth, converging on envelope‐associated mutations. Expressing the outer‐membrane transporter AlkL recapitulates much of the evolved phenotype, identifying substrate access and membrane ...
Raul Mireles, Lianet Noda‐García
wiley   +1 more source

Characterization of murine gammaherpesvirus 68 glycoprotein B (gB) homolog: similarity to Epstein-Barr virus gB (gp110) [PDF]

, 1994
Murine gammaherpesvirus 68 (MHV-68) is a natural pathogen of murid rodents and displays similar pathobiological characteristics to those of the human gammaherpesvirus Epstein-Barr virus (EBV).
Sunil-Chandra, N P, Nash, Anthony, Janjua, N J, Arrand, J R, Stewart, J.P.   +4 more
core  

Single-molecule fluorescence studies of Protein Folding and Molecular Chaperones [PDF]

, 2011
Folding of newly synthesized proteins is an essential part of protein biosynthesis and misfolding can result in protein aggregation which can also lead to several severe diseases.
Sikor, Martin
core   +1 more source