Results 61 to 70 of about 5,093 (138)

Germline minisatellite instability in the presence and absence of MLH1, a mismatch repair protein [PDF]

, 2014
MLH1 (MutL homolog 1) is a mismatch repair protein that can form heterodimer with MLH3 in meiosis. A functional MLH1-MLH3 heterodimer is essential for crossover recombination.
Shrestha, Kul
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Molecular classification of microsatellite-instable colorectal cancers reveals distinct predictors of immunotherapy response [PDF]

Microsatellite-instable (MSI) tumours constitute one-fifth of colorectal cancers (CRCs). However, the MSI CRCs display substantial tumour microenvironment (TME) heterogeneity and variable responses to immunotherapy, necessitating a refined classification
Ljuslinder, I., Ljuslinder, Ingrid, Hammarström, K., Luo, T., Isaksson, A., Palmqvist, R., Wu, M., Glimelius, Bengt, Glimelius, B., Wu, K., Sjöblom, T., Isaksson, Anders, Li, F., Nunes, L., Zhu, S., Lin, C., Sjöblom, Tobias, Uhlén, M., Mezheyeuski, A., Palmqvist, Richard   +19 more
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AN ABSTRACT OF THE THESIS OF Title: Functional Analysis of the Pathogenic Mutation MLH1-E578G on Human MLH1 activity in DNA Mismatch Repair All Rights Reserved Functional Analysis of the Pathogenic Mutation MLH1-E578G on Human MLH1 Activity in DNA Mismatc [PDF]

, 2020
approved: Andrew B. Buermeyer Mismatch repair (MMR) system performs mainly three roles to maintain genomic stability, correct DNA biosynthetic errors, ensure the fidelity of genetic recombination, and in mammalian cells participate in the cellular ...
Xin Huo
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AMPK Deficiency Increases DNA Methylation and Aggravates Colorectal Tumorigenesis in AOM/DSS Mice [PDF]

The incidence of colorectal cancer (CRC) is closely linked to metabolic diseases. Accumulating evidence suggests the regulatory role of AMP-activated protein kinase (AMPK) in cancer metabolic reprogramming. In this study, wild-type and AMPK knockout mice
Min Du, Qi Sun, Mei-Jun Zhu, Alejandro Bravo Iniguez, Qiyu Tian, Jeanene Deavila, Xiaofei Sun, Hui Zhang   +7 more
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Helicases and DNA dependent ATPases of Sulfolobus solfataricus [PDF]

, 2008
Electronic version does not contain associated previously published materialDNA is susceptible to various types of damage as a result of normal cellular metabolism or from environmental sources.
Richards, Jodi D.
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MutL protein homolog 1 isoform 1 from Homo sapiens [PDF]

, 2010
R. Lam, H. Zeng, A. Bochkarev, H. Wu, null null, J. Min, P. Loppnau, C. Bountra, C.H. Arrowsmith, J. Weigelt, A.M. Edwards   +10 more
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Mismatch repair protein MLH1 suppresses replicative stress in BRCA2-deficient breast tumors [PDF]

Loss of BRCA2 (breast cancer 2) is lethal for normal cells. Yet it remains poorly understood how, in BRCA2 mutation carriers, cells undergoing loss of heterozygosity overcome the lethality and undergo tissue -specific neoplastic transformation.
Singh, Vinod Kumar,, Subhajyoti De, Tyler Malys, Kharat, Suhas S., Zhao, Yongmei, Sharan, Shyam K., Lois McKennett, Mary E. Albaugh, Yongmei Zhao, Burkett, Sandra S., Xiaoju Hu, McKennett, Lois, Kuppusamy Balamurugan, Albaugh, Mary E., Peddibhotla, Vaishnavi, Sanawar, Rahul, Malys, Tyler, Vinod Kumar Singh, Esta Sterneck, Suhas S. Kharat, Shyam K. Sharan, Satheesh K. Sengodan, Hu, Xiaoju, Sengodan, Satheesh K., Bao Tran, Alexander Y. Mitrophanov, De, Subhajyoti, Balamurugan, Kuppusamy, Vaishnavi Peddibhotla, Tran, Bao, Sterneck, Esta, Rahul Sanawar, Sandra S. Burkett, Mitrophanov, Alexander Y.   +33 more
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Genotoxic effects of systemic chemotherapy in cancer patients, with special focus on the relation between MSI, LOH and development of secondary cancers [PDF]

, 2013
Systemic chemotherapy results in both phenotypic and genotypic side effects. Genotoxicity posed by chemotherapy is a major concern since it induces DNA damage and instability in the patients’ genome. Chemotherapy-related genetic instability is thought to
Rannug, Ulf,, Corso, Giovanni,, Kamat, Nasir K.,   +2 more
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Genetic regulation of iron responsive genes in sinorhizobium meliloti [PDF]

, 2005
Iron is an essential nutrient for most bacteria. It is a crucial metal of many metalloenzymes and functions m important biological systems mamly as the cofactor of redox enzymes Bacteria must acquire iron from the environment where the metal is mainly ...
Viguier, Caroline
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Hereditary non-polyposis colorectal carcinoma (HNPCC) : morphological and immunohistochemical studies [PDF]

, 2005
Includes bibliographical references.Families with hereditary non-polyposis colorectal carcinoma (HNPCC) are not uncommon along the West-Coast of South Africa.
Holm, Hannes
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