The role of testosterone in colorectal carcinoma : pathomechanisms and open questions [PDF]
, 2016 Colorectal cancer (CRC) is the fourth commonest type of malignancy after breast, lung and prostate in the USA and accounts for approximately 49,190 deaths annually in USA alone. The 5-year survival rate of CRC has increased over the past decades, in part,
Pace, Nikolai Paul +2 more
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Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: Genetic reclassification and correlation with clinical features [PDF]
, 2004 Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly ...
Baretton, G. +9 more
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Functional Characterization of MutS Homologue Mismatch Repair Proteins and their Variants [PDF]
, 2012 Lynch syndrome (LS) is one of the most common hereditary cancer syndromes and may lead to cancer development, mainly in colon or in endometrium, for 20 years earlier than in general population. LS is an autosomal dominantly inherited disorder, associated
Kantelinen, Jukka Petteri
core
Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models [PDF]
, 2016 The authors thank Medical Research Scotland and the Scottish Funding Council. This work was su pported by Medical Research Scotland [FRG353 to V.A.S.]; the FP7 -‐ Directorate -‐ General for Research and Innovation of the European Commission [EU HEALTH -
Francis, Kyle +6 more
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DNA Repair in Mammalian Cells: Mismatched repair: variations on a theme [PDF]
, 2018 .: Complementary base pairing underlies the genetic template function of the DNA double helix. Therefore, to assure faithful DNA transactions, cells must adhere to a strict application of the Watson-Crick base pairing principle.Yet, mispairing does arise
Kunz, C., Saito, Y., Schär, P.
core
, 2018 Stability of DNA largely depends on accuracy of repair mechanisms, which remove structural anomalies induced by exogenous and endogenous agents or introduced by DNA metabolism, such as replication. Most repair mechanisms include nucleolytic processing of
Fleck, O., Marti, T.
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Algorithms of maximum likelihood data clustering with applications
, 2002 We address the problem of data clustering by introducing an unsupervised, parameter free approach based on maximum likelihood principle. Starting from the observation that data sets belonging to the same cluster share a common information, we construct ...
Alter +17 more
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Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity. [PDF]
, 2018 The Hsp90 molecular chaperones are ATP-dependent enzymes that maintain protein homeostasis and regulate many essential cellular processes. Higher eukaryotes have organelle-specific Hsp90 paralogs that are adapted to each subcellular environment.
Agard, David A, Elnatan, Daniel
core
Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair [PDF]
, 2003 Argueso, Juan Lucas +5 more
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Deficient Mismatch Repair Subtypes in Vietnamese Colorectal Cancer: Clinicopathologic Associations, Predictive Modeling, and IHC-PCR Concordance. [PDF]
Cancer Manag ResTrinh HD +7 more
europepmc +1 more source