Results 81 to 90 of about 32,331,402 (154)

Assessing the functional asymmetry of the Bacillus subtilis MutL homodimer [PDF]

, 2017
DNA mismatch repair corrects base-base mismatches and small insertion/deletion loops generated during normal DNA replication. If left unrepaired, these errors become permanent mutations and can lead to increased susceptibility to cancer.
Liu, Linda
core   +1 more source

Brain imaging data and summary data-based Mendelian randomization analysis reveal the impact of multiorgan aging on schizophrenia

Frontiers in Psychiatry
AimThe adverse health outcomes of schizophrenia (SZ) are largely driven by the high prevalence of other non-neurological diseases. In addition to accelerated brain aging, patients with SZ also exhibit signs of systemic aging.
Yan-Kun Han, Yan-Kun Han, Miao-Yan Liu, Ding-long Yang, Jia-Xin Xie, Xiao-Hui Wang, Dong-Bao Wang, Yun-Long Liang, Cui-Cui Wang, Long-Biao Cui, Long-Biao Cui, Long-Biao Cui, Yu-Jing Chen, Hai-Jun Zhang, Hai-Jun Zhang   +14 more
doaj   +1 more source

Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System [PDF]

, 2018
Protein folding in the cell requires ATP-driven chaperone machines such as the conserved Hsp70 and Hsp90. It is enigmatic how these machines fold proteins.
Mayer, Matthias, Sub Cellular Protein Chemistry, Kityk, R., Rüdiger, S.G.D., Morán Luengo, T., Cellular Protein Chemistry   +5 more
core   +2 more sources

PTCH1 (patched homolog 1 (Drosophila)) [PDF]

, 1999
Review on PTCH1 (patched homolog 1 (Drosophila)), with data on DNA, on the protein encoded, and where the gene is ...
Huret, JL
core   +1 more source

Characterization of the MutL protein in Fluviicola taffensis

, 2012
Fluviicola taffensis is a gram negative fresh water bacterium which was studied in conjunction with the Joint Genomic Institute. Bioinformatics analysis of the genome sequence revealed that the genome was missing the MutH and DAM proteins within the DNA ...
Marshall K. Engstrom
core   +1 more source

Expressed protein ligation for a large dimeric protein [PDF]

, 2011
Expressed protein ligation (EPL) is a protein engineering tool for post-translational ligation of protein or peptide fragments. This technique allows modification of specific parts of proteins, opening possibilities for incorporating probes for ...
NMR Spectroscopy, Karagöz, G.E., Sub Cellular Protein Chemistry, O. Hsieh, Sub NMR Spectroscopy, T. Sinnige, Rüdiger, S.G.D., Hsieh, O., Sinnige, T, G. E. Karagoz, S. G. D. Rudiger, Cellular Protein Chemistry   +11 more
core   +1 more source

Functional characterization of the Caenorhabditis elegans gene fcd-2 during meiosis and in maintenance of genomic stability [PDF]

, 2009
Fanconi anemia (FA) is a complex cancer susceptibility disorder associated with defects in the repair of DNA interstrand cross-links (ICLs) resulting in occasional developmental defects and in ICL hypersensitivity of patient cells, yet the precise role ...
Silva, Nicola
core   +1 more source

Screening of mutL homolog 1 (MLH1) gene polymorpidsm using polymerase chain reaction (PCR) method [PDF]

, 2016
Incidence for colorectal cancer (CRC) a malignant tumor is rapidly increasing worldwide. The cancer arises may be influenced by many risk factors, including lifestyle and genetic inherited. In this study, the main interest is to screen the inheritance of
Mohamad Hanapi, Siti Zaharah
core  

Why similar protein sequences encode similar three-dimensional structures? [PDF]

, 2010
Evolutionarily related proteins have similar sequences. Such similarity is called homology and can be described using substitution matrices such as Blosum 60.
Zielenkiewicz, Piotr, Kaczanowski, Szymon   +1 more
core   +1 more source

The DNA binding properties of the MutL protein isolated from Escherichia coli

, 1991
The mutL gene of Escherichia coli, which is involved in the repair of mlspaired and unpaired nucleotides in DNA, has been independently cloned and the gene product purified.
Steven M. Bende, Robert H. Grafstrom
core