Results 71 to 80 of about 32,331,402 (154)

Incidental Colorectal Adenomas in Adolescents: Clinical Management, Genetic Evaluation, and Surveillance

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1743-1750, June 2026.
Adolescents with incidental colorectal adenomas require age‐conscious management balancing referral for genetic counseling with evidence‐based surveillance. This narrative review proposes a pragmatic clinical algorithm integrating adenoma characteristics, hereditary risk assessment, and guideline‐concordant follow‐up to support individualized ...
Brett J. Hoskins, Shlomi Cohen, Colleen B. Flahive, Isabel Rojas, Aparajita Singh, Thomas M. Attard   +5 more
wiley   +1 more source

The Keynote‐177 Randomized Controlled Trial of First‐line PD‐1 Blockade for Microsatellite‐High or Mismatch Repair‐Deficient Advanced Colorectal Cancer: Potential Consequences of the Cross‐Over Trial Design and Related Issues

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Some new oncology drugs offer substantial patient health benefit. However, due to high costs, many remain unavailable to patients in low‐ and middle‐income countries. Next to exorbitant drug pricing, uncertainty of the magnitude of benefit of new treatments can contribute to differences in global access to cancer treatments, even in high ...
S. L. Gerritse, E. van Meerten, A. J. Duits, J. B. Schnog   +3 more
wiley   +1 more source

Establishment of a Model to Predict the Prognosis of Endometrial Carcinoma Using Tumor‐Infiltrating Lymphocytes Evaluated With Artificial Intelligence: A Retrospective Analysis

Cancer Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background The objective of this study was to establish a new model for predicting the prognosis of endometrial carcinoma (EC) using tumor‐infiltrating lymphocytes (TILs) based on artificial intelligence (AI). Methods Patients with EC who were treated between 1989 and 2022 were included in this study.
Taira Hada, Morikazu Miyamoto, Takahiro Einama, Soichiro Kakimoto, Makiko Koga, Takanori Watanabe, Yuka Otsuka, Jin Suminokura, Tsubasa Ito, Naohisa Kishimoto, Risa Tanabe, Soko Nishimura, Kento Kato, Hiroaki Soyama, Kohei Omatsu, Yoshinobu Hamada, Kimiya Sato, Masashi Takano   +17 more
wiley   +1 more source

The Escherichia coli MutL Protein Physically Interacts with MutH and Stimulates the MutH-associated Endonuclease Activity [PDF]

, 1999
All possible pairwise combinations of UvrD, MutL, MutS, and MutH were tested using the yeast two-hybrid system to identify potential interactions involving mismatch repair proteins. A two-hybrid screen previously identified a physical interaction between
Matson, Steven W., Hall, Mark C.
core   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 [PDF]

, 1998
Nek2 (for NIMA-related kinase 2) is a mammalian cell cycle-regulated kinase structurally related to the mitotic regulator NIMA of Aspergillus nidulans.
Fry, A. M., Erich A. Nigg, Stierhof, Y. D., Mayor, T., Y. D. Stierhof (7653686), Tanaka, K., Nigg, E. A., Meraldi, P., Thibault Mayor, A. M. Fry (7651490), E. A. Nigg (7651493), Kayoko Tanaka, Andrew M. Fry, P. Meraldi (7653683), K. Tanaka (1500880), Patrick Meraldi, York-Dieter Stierhof, T. Mayor (7653680)   +17 more
core   +1 more source

Cloning and characterization of mutL and mutS genes of Vibrio cholerae: nucleotide sequence of the mutL gene [PDF]

, 1989
The mutL and mutS genes of Vibrio cholerae have been identified using interspecific complementation of Escherichia coli mutL and mutS mutants with plasmids containing the gene bank of V. cholerae.
Das, Jyotirmoy, Ghosh, Subrata K., Bera, Tapan Kumar   +2 more
core   +1 more source

The cationic region of Rhes mediates its interactions with specific Gβ subunits [PDF]

, 2009
Ras homologue enriched in striatum (Rhes) is a small monomeric G protein which functions in a variety of cellular processes, including attenuation of G protein-coupled receptor (GPCR)signalling.
Ladds, Graham, Hill, Claire, Goddard, Alan, Davey, John   +3 more
core   +1 more source

Structure of the Endonuclease Domain of MutL: Unlicensed to Cut [PDF]

, 2010
DNA mismatch repair corrects errors that have escaped polymerase proofreading, increasing replication fidelity 100- to 1000-fold in organisms ranging from bacteria to humans.
Lyle A. Simmons, Paul Modrich, Walker, Graham C., Klocko, Andrew D., Peter Friedhoff, Lorenowicz, Jessica J., Alba Guarné, Andrew D. Klocko, Guarne, Alba, Yu Seon Chung, Monica C. Pillon, Friedhoff, Peter, Chung, Yu Seon, Michael Uckelmann, Graham C. Walker, Ryan R. Mitchell, Pillon, Monica C., Uckelmann, Michael, Mitchell, Ryan R., Jessica J. Lorenowicz, Simmons, Lyle A., Modrich, Paul   +21 more
core   +1 more source

The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells [PDF]

, 2008
The protein product of the ocular albinism type 1 gene, named OA1, is a pigment cell-specific G protein-coupled receptor exclusively localized to intracellular organelles, namely lysosomes and melanosomes.
Bennett, DC, Venturi C, Palmigiano, A, Schiaffino, MV, Piccirillo, R, Altimare D., Rotondo G., Tacchetti, C, Marigo, V, Bagnato P., Coppola M., Rotondo, G, Venturi, C, Sviderskaya, EV, Palmisano I., Palmigiano A., Altimare D, Bagnato, P, Marigo V., Surace, EM, Altimare, D, Tacchetti C, Innamorati G., Venturi C., Surace E. M., Palmisano I, Rotondo G, INNAMORATI, Giulio, BALLABIO, ANDREA, Schiaffino M. V., Sviderskaya E. V., Palmigiano A, Innamorati G, SURACE, Enrico Maria, Sviderskaya EV, Piccirillo R, Bagnato P, Ballabio A., Incerti B, Piccirillo R., Tacchetti C., Schiaffino MV, Coppola, M, Incerti, B, Bennett DC, Incerti B., Palmisano, I, Coppola M, Bennett D. C., Innamorati, G, Ballabio, A, Marigo V   +51 more
core   +1 more source