Results 71 to 80 of about 8,700 (159)

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T‐Cell Exhaustion in Dysgerminoma

Cancer Science, Volume 117, Issue 2, Page 566-575, February 2026.
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima, Takeshi Iwasaki, Yoshihiro Katayama, Masatoshi Shimo, Ken Takigawa, Naomi Shimada, Michiko Matsushita, Satoshi Kuwamoto, Shinya Sato, Masato Toya, Kohta Miyawaki, Koichi Akashi, Kiyoko Kato, Yoshinao Oda   +13 more
wiley   +1 more source

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, Volume 13, Issue 4, 19 January 2026.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

Integrative Mendelian Randomization and Pathomics Analysis Using Expression Quantitative Trait Loci and Genome‐Wide Association Study Data Identifies Mismatch Repair Genes as Prognostic Biomarkers in Gastric Adenocarcinoma

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Background Mismatch repair (MMR) genes are implicated in stomach adenocarcinoma (STAD). This study assessed their causal role in STAD, prognostic value, and developed a histopathology‐based model to predict MutS homolog 2 (MSH2) expression. Methods Using data from the IEU OpenGWAS database, five Mendelian randomization (MR) models evaluated causal ...
Yingqiao Zhang, Dan Li, Yuyao Jin, Wenjuan Zhao, Pengyu Guo, Ziqi Wang, Xinyu Zhu, Zhenqi Ma, Lin Sui, Yanmeng Liang, Yang Liu, Xiushi Zhang, Zhijie Xu   +12 more
wiley   +1 more source

Diffuse large B cell lymphoma presenting as Horner's syndrome in a patient diagnosed with neurofibromatosis type 1: a case report and review of the literature [PDF]

, 2012
Introduction Horner's syndrome has a variety of etiologies ranging from benign to serious life-threatening conditions and has been infrequently reported as a presenting symptom of patients with lymphoid neoplasms.
Saoraya Lueangarun, Chirayu U Auewarakul
core   +1 more source

The Enigmatic Teratoma: Tracing Tissue Origins Through Methylation Profiling

Stem Cells International, Volume 2026, Issue 1, 2026.
Purpose Mature cystic teratomas of the ovary can contain skin, hair, muscle, and bone and are usually found in women of reproductive age. Elucidating epigenomic aberrations in these teratomas may result in a better understanding of their stepwise developmental processes and molecular bases. Methods Here, we analyzed the methylation statuses of promoter
Wen-Chung Wang, Chen-Yun Kuo, Tai-Cheng Hou, Yen-Chein Lai, Harleen Khatra   +4 more
wiley   +1 more source

Structure of the Endonuclease Domain of MutL: Unlicensed to Cut [PDF]

, 2010
DNA mismatch repair corrects errors that have escaped polymerase proofreading, increasing replication fidelity 100- to 1000-fold in organisms ranging from bacteria to humans.
Chung, Yu Seon, Friedhoff, Peter, Guarne, Alba, Klocko, Andrew D., Lorenowicz, Jessica J., Mitchell, Ryan R., Modrich, Paul, Pillon, Monica C., Simmons, Lyle A., Uckelmann, Michael, Walker, Graham C.   +10 more
core   +1 more source

Brain imaging data and summary data-based Mendelian randomization analysis reveal the impact of multiorgan aging on schizophrenia

Frontiers in Psychiatry
AimThe adverse health outcomes of schizophrenia (SZ) are largely driven by the high prevalence of other non-neurological diseases. In addition to accelerated brain aging, patients with SZ also exhibit signs of systemic aging.
Yan-Kun Han, Yan-Kun Han, Miao-Yan Liu, Ding-long Yang, Jia-Xin Xie, Xiao-Hui Wang, Dong-Bao Wang, Yun-Long Liang, Cui-Cui Wang, Long-Biao Cui, Long-Biao Cui, Long-Biao Cui, Yu-Jing Chen, Hai-Jun Zhang, Hai-Jun Zhang   +14 more
doaj   +1 more source

MicroRNAs in non-small cell lung cancer: Gene regulation, impact on cancer cellular processes, and therapeutic potential. [PDF]

, 2019
Lung cancer remains the most lethal cancer among men and women in the United States and worldwide. The majority of lung cancer cases are classified as non-small cell lung cancer (NSCLC). Developing new therapeutics on the basis of better understanding of
Petrek, Hannah, Yu, Ai-Ming
core   +1 more source

Drugging the Cancers Addicted to DNA Repair [PDF]

, 2017
Defects in DNA repair can result in oncogenic genomic instability. Cancers occurring from DNA repair defects were once thought to be limited to rare inherited mutations (such as BRCA1 or 2).
Hromas, Robert, Jones, Dennie, Lee, Suk-Hee, Nickoloff, Jac A., Williamson, Elizabeth A.   +4 more
core   +1 more source

Evaluation of MT1XT20 single quasi-monomorphic mononucleotide marker for characterizing microsatellite instability in persian lynch syndrome patients [PDF]

, 2016
Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy.
Emami, Mohammad Hassan., Farahani, Najmeh., Hashemzadeh-Chaleshtori, Morteza., Nikpour, Parvaneh., Salehi, Rasoul., Shariatpanahi, Seyed Shervin., Zeinalian, Mehrdad.   +6 more
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