Results 51 to 60 of about 32,331,402 (154)

Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors [PDF]

, 2002
GABA(A) receptors are the principal sites of fast synaptic inhibition in the brain. These receptors are hetero-pentamers that can be assembled from a number of subunit classes: alpha(1-6), beta(1-3), gamma(1-3), delta(1), epsilon, theta, and pi, but the ...
Trevor G Smart, Brandon, NJ, Jovanovic, JN, Moss, SJ, Stephen J Moss, Smart, TG, Nicholas J Brandon, Jasmina N Jovanovic   +7 more
core  

Depleted-MLH1 Expression Predicts Prognosis and Immunotherapeutic Efficacy in Uterine Corpus Endometrial Cancer: An In Silico Approach

BioMedInformatics
Uterine corpus endometrial carcinoma (UCEC) poses significant clinical challenges due to its high incidence and poor prognosis, exacerbated by the lack of effective screening methods.
Tesfaye Wolde, Jing Huang, Peng Huang, Vijay Pandey, Peiwu Qin   +4 more
doaj   +1 more source

Ataxin-1 fusion partners alter polyQ lethality and aggregation [PDF]

, 2007
Intranuclear inclusion bodies (IBs) are the histopathologic markers of multiple protein folding diseases. IB formation has been extensively studied using fluorescent fusion products of pathogenic polyglutamine (polyQ) expressing proteins.
Rich, T., Varadaraj, A., Archana Varadaraj, Varadaraj Archana, Tina Rich, Rich Tina   +5 more
core   +2 more sources

Production And Purification Of Mutl Gene And Uvrd Recombinant Protein For Helicase Dependent Dna Amplification [PDF]

, 2015
Kajian ini telah dijalankan untuk mengoptimumkan penghasilan rekombinan UvrD helicase dan rekombinan MutL protein untuk ujian amplifikasi helicase. Rekombinan UvrD helicase telah diklon dan diekspresikan dengan vektor Lemo21.
Buskaran, Kalaivani
core   +1 more source

Molecular classification of microsatellite-instable colorectal cancers reveals distinct predictors of immunotherapy response

ESMO Gastrointestinal Oncology
Microsatellite-instable (MSI) tumours constitute one-fifth of colorectal cancers (CRCs). However, the MSI CRCs display substantial tumour microenvironment (TME) heterogeneity and variable responses to immunotherapy, necessitating a refined classification
C. Lin, T. Luo, M. Wu, F. Li, L. Nunes, A. Mezheyeuski, K. Hammarström, A. Isaksson, I. Ljuslinder, M. Uhlén, R. Palmqvist, S. Zhu, B. Glimelius, K. Wu, T. Sjöblom   +14 more
doaj   +1 more source

BRAFV600E mutation and its association with clinicopathological features of colorectal cancer: a systematic review and meta-analysis.

PLoS ONE, 2014
BackgroundColorectal cancer (CRC) is a heterogeneous disease with multiple underlying causative genetic mutations. The B-type Raf proto-oncogene (BRAF) plays an important role in the mitogen-activated protein kinase (MAPK) signaling cascade during CRC ...
Dong Chen, Jun-Fu Huang, Kai Liu, Li-Qun Zhang, Zhao Yang, Zheng-Ran Chuai, Yun-Xia Wang, Da-Chuan Shi, Qing Huang, Wei-Ling Fu   +9 more
doaj   +1 more source

Genetic analysis of primary lung interdigitating dendritic cell sarcomas

The Journal of Pathology, Volume 269, Issue 4-5, Page 387-398, August 2026.
Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov, Juliana Faria Filipe, Sylvia Eidenhammer, German Ott, Iris Halbwedl, Karl Kashofer, Helmut Popper   +6 more
wiley   +1 more source

Les homologues de MutS et de MutL au cours de la méiose chez les mammifères

, 2003
La recombinaison méiotique correspond à des échanges réciproques de matériel génétique entre les chromosomes homologues maternels et paternels. Ces échanges sont nécessaires à la ségrégation correcte des chromosomes homologues lors de la première ...
Sabine Santucci-Darmanin, Santucci-Darmanin, Sabine, Véronique Paquis-Flucklinger, Paquis-Flucklinger, Véronique   +3 more
core   +1 more source

Pyramidalization of the Glycosidic Nitrogen Provides the Way for Efficient Cleavage of the N‑Glycosidic Bond of 8‑OxoG with the hOGG1 DNA Repair Protein [PDF]

, 2012
A mechanistic pathway for cleavage of the N-glycosidic bond of 8-oxo-2′-deoxyguanosine (oxoG) catalyzed with the human 8-oxoguanine glycosylase 1 DNA repair protein (hOGG1) is proposed in this theoretical study. The reaction scheme suggests direct proton
Sychrovský, V., Sub Cellular Protein Chemistry, Sebera, J., Tanaka, Y., Trantirek, L., Cellular Protein Chemistry   +5 more
core   +1 more source

Metastatic Unfunctional Pancreatic Neuroendocrine Tumor in Lynch Syndrome

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Lynch syndrome (LS), a well‐known cancer risk syndrome, is caused by deleterious germline mutations in the mismatch repair genes. LS predispose patients to various types of cancers including colon adenocarcinoma. We discuss the case of a woman with LS who also developed a non‐functioning pancreatic neuroendocrine tumor (P‐NET) following ...
Fateme Salemi, Zahra Sadin, Atefe Barzegari, Seyed Mohammad Reza Mortazavizadeh, Massih Bahar, Motahare Amiri   +5 more
wiley   +1 more source