MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 6, Page 1616-1620, March 2026.The urgent need for sustainable agriculture places biological nitrogen fixation at the forefront of current biotechnological research. Plant growth‐promoting rhizobacteria play crucial roles in agriculture by enhancing nutrient absorption, regulating hormonal balance, and providing reduced nitrogen to plants. Among these, diazotrophic bacteria, such as
Edileusa Cristina Marques Gerhardt +1 more
wiley +1 more source
Circulating-free DNA Mutation Associated with Response of Targeted Therapy in Human Epidermal Growth Factor Receptor 2-positive Metastatic Breast Cancer [PDF]
, 2017 Background: The addition of anti-human epidermal growth factor receptor 2 (HER2)-targeted drugs, such as trastuzumab, lapatinib, and trastuzumab emtansine (T-DM1), to chemotherapy significantly improved prognosis of HER2-positive breast cancer patients ...
Ze-Fei Jiang +5 more
core +1 more source
A Clinical Guidance for the Management of Patients With Hepatoid Adenocarcinoma and A Case Series
Cancer Medicine, Volume 15, Issue 2, February 2026.ABSTRACT Hepatoid adenocarcinoma (HAC) is a rare extrahepatic tumor of non‐germ cell origin that morphologically resembles hepatocellular carcinoma (HCC). HAC has a propensity to metastasize to the liver and therefore may be mistaken for HCC. There is a lack of standardized treatment protocols, and further studies are needed to evaluate the benefit of ...
Christina Liava +4 more
wiley +1 more source
Microsatellite instability in colorectal cancer. [PDF]
, 2019 Cilj: Ispitati učestalost mikrosatelitski nestabilnih kolorektalnih karcinoma (CRC) u odnosu na spol, dob i TNM stadij bolesti, u dvogodišnjem razdoblju u Kliničkom bolničkom centru Osijek (KBCO).
Kašuba, Antonija
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Depleted-MLH1 Expression Predicts Prognosis and Immunotherapeutic Efficacy in Uterine Corpus Endometrial Cancer: An In Silico Approach [PDF]
Uterine corpus endometrial carcinoma (UCEC) poses significant clinical challenges due to its high incidence and poor prognosis, exacerbated by the lack of effective screening methods.
Tesfaye Wolde +4 more
core +1 more source
Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors [PDF]
, 2018 Background To screen tumors with microsatellite instability (MSI) arising due to DNA mismatch repair deficiency (dMMR), a panel of five quasi-monomorphic mononucleotide-repeat markers amplified in a multiplex PCR (Pentaplex) are commonly used.
Junko Haraga +9 more
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Molecular markers associated with response to chemotherapy in gastro-entero-pancreatic neuroendocrine tumors [PDF]
, 2010 Response rates to cytotoxics in gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) vary; recent trials demonstrated lack of objective response rates in up to 70% of patients.
Philippe Levy +9 more
core +1 more source
Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability [PDF]
, 2019 Summary: Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss-of-function mutations in WRN led to premature aging and predisposition to cancer.
Senthil K. Perumal +3 more
core +1 more source
Recombination homeostasis of meiosis during spermatogenesis under nicotine treatment [PDF]
, 2018 Cigarette smoking can affect male fertility via the quality of semen. To explore the effects of nicotine, a major component of cigarettes, on meiotic recombination during spermatogenesis, C57BL/6J male mice were injected with nicotine at a dosage of 0.2 ...
Zhai Jingli +7 more
core +1 more source