Results 31 to 40 of about 5,093 (138)
Metastatic Unfunctional Pancreatic Neuroendocrine Tumor in Lynch Syndrome
Clinical Case Reports, Volume 14, Issue 7, July 2026.ABSTRACT Lynch syndrome (LS), a well‐known cancer risk syndrome, is caused by deleterious germline mutations in the mismatch repair genes. LS predispose patients to various types of cancers including colon adenocarcinoma. We discuss the case of a woman with LS who also developed a non‐functioning pancreatic neuroendocrine tumor (P‐NET) following ...
Fateme Salemi +5 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.ABSTRACT Colorectal cancer (CRC) has raised considerable health concerns worldwide, with increasing incidence rates, specifically among younger populations. Despite remarkable progress in diagnosing and treating various diseases, the genetic basis of CRC remains only partially understood.
Behnaz Bagheri +7 more
wiley +1 more source
Identification of Driving ALK Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer. [PDF]
, 2015 The genetic landscape of medullary thyroid cancer (MTC) is not yet fully understood, although some oncogenic mutations have been identified. To explore genetic profiles of MTCs, formalin-fixed, paraffin-embedded tumor tissues from MTC patients were ...
Keunchil Park (416101) +27 more
core +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners [PDF]
, 2018 Eukaryotic DNA mismatch repair (MMR) involves both exonuclease 1 (Exo1)-dependent and Exo1-independent pathways. We found that the unstructured C-terminal domain of Saccharomyces cerevisiae Exo1 contains two MutS homolog 2 (Msh2)-interacting peptide ...
William J. Graham +11 more
core +1 more source
Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics
MedComm – Oncology, Volume 5, Issue 2, June 2026.Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang +7 more
wiley +1 more source
Loss of CDX2 gene expression is associated with DNA repair proteins and is a crucial member of the Wnt signaling pathway in liver metastasis of colorectal cancer [PDF]
, 2018 Caudal type homeobox 2 (CDX2) has been well-established as a diagnostic marker for colorectal cancer (CRC); however, less is known about its regulation, particularly its potential interactions with the DNA repair proteins, adenomatous polyposis coli (APC)
Tiszlavicz László +5 more
core +1 more source
MedComm – Oncology, Volume 5, Issue 2, June 2026.Endometrial cancer (EC), a major gynecologic malignancy and a representative “cold tumor”, exhibits a tumor immune microenvironment (TIME) influenced by a broad range of cellular and molecular elements, immunosuppressive signals, and pathways of immune evasion.
Jingxuan Ye +4 more
wiley +1 more source
Implementation of a lynch syndrome screening protocol on colorectal cancer patients 70 years of age and under: the initial Manitoba screening experience [PDF]
, 2017 Objective: Assess the ability of a Manitoba instituted Lynch Syndrome (LS), an autosomal dominant cancer syndrome, screening protocol to identify carriers in colorectal cancer (CRC) patients as compared to literature.
Sexsmith, Laura
core
Microbial Biotechnology, Volume 19, Issue 6, June 2026.Pseudomonas putida KT2440 grows on polyethylene‐derived long‐chain alcohols (C16OH, C20OH) as sole carbon sources. Adaptive laboratory evolution rapidly increases growth, converging on envelope‐associated mutations. Expressing the outer‐membrane transporter AlkL recapitulates much of the evolved phenotype, identifying substrate access and membrane ...
Raul Mireles, Lianet Noda‐García
wiley +1 more source