Results 21 to 30 of about 8,700 (159)

Meiosis genes in and the role of parthenogenesis in genome evolution [PDF]

, 2009
Background Thousands of parthenogenetic animal species have been described and cytogenetic manifestations of this reproductive mode are well known. However, little is understood about the molecular determinants of parthenogenesis.
Andrew M Schurko, John M Logsdon, Brian D Eads, GN Stone, M Lynch, J Mallet, M Morgan-Richards, MF Dybdahl, C Wallace, PM Ferree, MG Riparbelli, E Suomalainen, TA Gorr, N Tatarazako, PD Hebert, F Zaffagnini, H Lumer, F Zaffagnini, AR Omilian, JK Colbourne, S Paland, M Lynch, PE Cohen, K Nasmyth, JL Gerton, S Hauf, M Petronczki, Y Watanabe, J Brennecke, AA Aravin, C Klattenhoff, T Kishimoto, AL Marston, JZ Morris, M Fu, Y Geng, S Ortega, M Malumbres, M Kasten, O Cohen-Fix, K Nasmyth, V Guacci, SP Bell, SL Forsburg, D Maiorano, HL Blanton, M Lutzmann, JW Barnes, AL Gotter, RC Chan, AL Gotter, JA Cobb, L Wu, RM Brosh Jr, ID Hickson, JL Plank, B Rockmill, PB Moens, DN Cox, K Nonomura, MA Ramesh, S Gruber, TS Kitajima, SE Thomas, L Strom, E Unal, I Sumara, A Losada, VL Katis, TS Kitajima, DQ Ding, G De Piccoli, J Torres-Rosell, A Losada, T Hirano, N Cobbe, E Revenkova, N Pezzi, A Bergerat, S Keeney, SB Malik, DK Bishop, A Shinohara, JY Masson, A Shinohara, DK Bishop, M Tarsounas, GV Petukhova, RJ Pezza, G Petukhova, M Shinohara, N Sarai, J Wesoly, GV Petukhova, C Zierhut, NY Stassen, Z Lin, J Jiricny, T Snowden, S Neyton, Z Lin, KM Culligan, TF Wang, M Raschle, GM Li, SM Baker, SM Lipkin, S Santucci-Darmanin, E Cannavo, PC Chen, P Pasierbek, S Yokobayashi, R Chenna, DR Maddison, F Ronquist, S Whelan   +115 more
core   +1 more source

Factors modifying the risk for developing acute skin toxicity after whole-breast intensity modulated radiotherapy [PDF]

, 2014
Background: After breast-conserving radiation therapy most patients experience acute skin toxicity to some degree. This may impair patients' quality of life, cause pain and discomfort. In this study, we investigated treatment and patient-related factors,
De Langhe, Sofie, De Neve, Wilfried, De Ruyck, Kim, DE SCHEPPER, ELINE, Gilsoul, Monique, MULLIEZ, THOMAS, Remouchamps, Vincent, Thierens, Hubert, van Greveling, Annick, Veldeman, Liv   +9 more
core   +2 more sources

Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability

iScience, 2019
Summary: Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss-of-function mutations in WRN led to premature aging and predisposition to cancer.
Lorn Kategaya, Senthil K. Perumal, Jeffrey H. Hager, Lisa D. Belmont   +3 more
doaj   +1 more source

Prognostic Significance of ARID1A Expression Patterns Varies with Molecular Subtype in Advanced Gastric Cancer

Gut and Liver, 2023
Background/Aims: AT-rich interactive domain 1A (ARID1A) is frequently mutated in gastric cancer (GC), especially Epstein-Barr virus (EBV)-associated and microsatellite instability high GC.
Jun Yong Kim, Cheol Keun Park, Songmi Noh, Jae-Ho Cheong, Sung Hoon Noh, Hyunki Kim   +5 more
doaj   +1 more source

DNA repair mechanisms and gametogenesis [PDF]

, 2001
In mammals, there is a complex and intriguing relationship between DNA repair and gametogenesis. DNA repair mechanisms are involved not only in the repair of different types of DNA damage in developing germline cells, but ...
Baarends, W.M. (Willy), Grootegoed, J.A. (Anton), Laan, R. (Roald) van der   +2 more
core   +2 more sources

Characterization and comparative sequence analysis of the DNA mismatch repair MSH2 and MSH7 genes from tomato [PDF]

, 2009
DNA mismatch repair proteins play an essential role in maintaining genomic integrity during replication and genetic recombination. We successfully isolated a full length MSH2 and partial MSH7 cDNAs from tomato, based on sequence similarity between MutS ...
Tam, Sheh May, Samipak, Sompid, Britt, Anne, Chetelat, Roger T.   +3 more
core   +1 more source

Leucine modulates the IPEC-J2 cell proteome associated with cell proliferation, metabolism and phagocytosis

Animal Nutrition, 2018
Leucine can affect intestinal protein expressions, and improve mucosal immune function. However, little study has been conducted to determine the change of protein component by leucine treatment in intestine epithelial cells.
Xiangbing Mao, Man Ren, Daiwen Chen, Bing Yu, Lianqiang Che, Jun He, Junqiu Luo, Yuheng Luo, Jianping Wang, Hui Sun   +9 more
doaj   +1 more source

Diagnosis and functional prediction of microbial markers in tumor tissues of sporadic colorectal cancer patients associated with the MLH1 protein phenotype

Frontiers in Oncology, 2023
ObjectiveMost patients with sporadic colorectal cancer (SCRC) develop microsatellite instability because of defects in mismatch repair (MMR). Moreover, the gut microbiome plays a vital role in the pathogenesis of SCRC.
Anchao Zhu, Anchao Zhu, Yingying Liu, Zongmin Li, Ying He, Lijing Bai, Youtian Wu, Yuying Zhang, Ying Huang, Ping Jiang   +9 more
doaj   +1 more source

Endonuclease activities of MutLα and its homologs in DNA mismatch repair. [PDF]

, 2016
MutLα is a key component of the DNA mismatch repair system in eukaryotes. The DNA mismatch repair system has several genetic stabilization functions. Of these functions, DNA mismatch repair is the major one.
Kadyrov, Farid A, Kadyrova, Lyudmila Y
core   +2 more sources

Clinical exome performance for reporting secondary genetic findings. [PDF]

, 2014
BACKGROUND : Reporting clinically actionable incidental genetic findings in the course of clinical exome testing is recommended by the American College of Medical Genet- ics and Genomics (ACMG).
Clark, P, Fortina, Paolo, Kricka, Lj, Londin, E, Park, J. Y., Park, Jy, Sponziello, Marialuisa   +6 more
core   +1 more source