Role of evaluating tumor‐infiltrating lymphocytes, programmed death‐1 ligand 1 and mismatch repair proteins expression in malignant mesothelioma [PDF]
, 2019 The tumor immune microenvironment (TME) and immune checkpoints have been reported to serve a role in the pathogenesis of malignant mesothelioma (MM) and treatment outcome.
Bertolini, Federica +11 more
core +1 more source
DataSheet_2_Diagnosis and functional prediction of microbial markers in tumor tissues of sporadic colorectal cancer patients associated with the MLH1 protein phenotype.zip [PDF]
, 2023 ObjectiveMost patients with sporadic colorectal cancer (SCRC) develop microsatellite instability because of defects in mismatch repair (MMR). Moreover, the gut microbiome plays a vital role in the pathogenesis of SCRC.
Yingying Liu (360782) +8 more
core +1 more source
Identification and Characterization of a Vsr Homolog from Bacillus stearothermophilus [PDF]
, 2001 In dieser Arbeit wurde zunächst eine Methode entwickelt, mit deren Hilfe ausgehend von nur einer konservierten Aminosäureregion einer Proteinfamilie mittels PCR Fragmente unbekannter Gene isoliert werden können,
Laging, Martin
core +1 more source
Identification of novel genetic and prognostic markers in hereditary and sporadic cancer: "two sides of the same coin" [PDF]
, 2012 This thesis has focused on the discovery and characterization of novel diagnostic and prognostic markers in various cancer entities, with a special emphasis on colorectal cancer (CRC).
Piscuoglio, Salvatore
core +1 more source
The Prediction of the Expected Current Selection Coefficient of Single Nucleotide Polymorphism Associated with Holstein Milk Yield, Fat and Protein Contents [PDF]
, 2016 Milk-related traits (milk yield, fat and protein) have been crucial to selection of Holstein. It is essential to find the current selection trends of Holstein. Despite this, uncovering the current trends of selection have been ignored in previous studies.
Lee, Young-Sup +13 more
core +1 more source
Distribution of MLH1 Foci in Horse Male Synaptonemal Complex [PDF]
, 2014 Advances in molecular cytogenetics have provided the opportunity to study events during prophase I of meiosis. Immunofluorescent localization of different meiotic protein components were used to characterize the early stages of the first meiotic division
Goodwin, William H +3 more
core +1 more source
a–d): eQTLs with simultaneous impact on expression levels of at least five genes in trans. [PDF]
, 2014 a) Chromosome 12. The eQTL was located upstream of lysozyme (LYZ), a gene residing on chromosome 12q15. It is associated with expression levels of the seven transcripts cAMP responsive element binding protein 1 (CREB1), SHC SH2-domain binding protein 1 ...
Astrid Petersmann (552979) +28 more
core +1 more source
Novel MSH2 splice-site mutation in a young patient with Lynch syndrome [PDF]
, 2018 Lynch Syndrome (LS) is associated with germline mutations in one of the mismatch repair (MMR) genes, including MutL homolog 1 (MLH1), MutS homolog 2 (MSH2), MSH6, PMS1 homolog 2, mismatch repair system component (PMS2), MLH3 and MSH3.
RAFFAELLA LICCARDO +3 more
core +1 more source
Genetic analysis of primary lung interdigitating dendritic cell sarcomas
The Journal of Pathology, Volume 269, Issue 4-5, Page 387-398, August 2026.Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov +6 more
wiley +1 more source
Evidence for breast cancer as an integral part of Lynch syndrome [PDF]
, 2012 Lynch syndrome, an autosomal dominant cancer predisposition caused by mutations in DNA mismatch repair (MMR) genes, mainly mainly mutL homolog 1, OMIM 120436 (MLH1) and mutS homolog 2, OMIM 609309 (MSH2), encompasses a tumor spectrum including primarily ...
Mueller, Hansjakob +7 more
core +1 more source