Results 21 to 30 of about 32,331,402 (154)

The Prediction of the Expected Current Selection Coefficient of Single Nucleotide Polymorphism Associated with Holstein Milk Yield, Fat and Protein Contents [PDF]

Asian-Australasian Journal of Animal Sciences, 2016
Milk-related traits (milk yield, fat and protein) have been crucial to selection of Holstein. It is essential to find the current selection trends of Holstein. Despite this, uncovering the current trends of selection have been ignored in previous studies.
Young-Sup Lee, Donghyun Shin, Wonseok Lee, Mengistie Taye, Kwanghyun Cho, Kyoung-Do Park, Heebal Kim   +6 more
doaj   +1 more source

Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability

iScience, 2019
Summary: Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss-of-function mutations in WRN led to premature aging and predisposition to cancer.
Lorn Kategaya, Senthil K. Perumal, Jeffrey H. Hager, Lisa D. Belmont   +3 more
doaj   +1 more source

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA [PDF]

, 2015
To avoid mutations in the genome, DNA replication is generally followed by DNA mismatch repair (MMR). MMR starts when a MutS homolog recognizes a mismatch and undergoes an ATP-dependent transformation to an elusive sliding clamp state. How this transient
Murshudov, GN, Alexander Fish, Reumer, A, Winterwerp, HHK, Cristovao, M. (Michele), Reumer, A. (Annet), Robert A Nicholls, Sixma, T.K., Winkler, I. (Ines), Groothuizen, FS, Hermans, Nicolaas, Sixma, Nicholls, R.A. (Robert A.), Friedhoff, P. (Peter), Winkler, I, Cristovao, Michele, Murshudov, G.N. (Garib N.), Joyce HG Lebbink, Nicholls, RA, Herrie HK Winterwerp, Lebbink, J.H.G. (Joyce), Friedhoff, P, Lebbink, Joyce, Fish, A. (Alexander), Winterwerp, H.H.K. (Herrie), Ines Winkler, Hermans, N. (Nicolaas), Peter Friedhoff, Garib N Murshudov, Fish, A, Marx, A.D. (Andreas), Flora S Groothuizen, Nicolaas Hermans, Titia K Sixma, Sixma, T.K. (Titia), Annet Reumer, Andreas D Marx, Groothuizen, F.S. (Flora), Michele Cristóvão, Marx, AD   +39 more
core   +1 more source

Leucine modulates the IPEC-J2 cell proteome associated with cell proliferation, metabolism and phagocytosis

Animal Nutrition, 2018
Leucine can affect intestinal protein expressions, and improve mucosal immune function. However, little study has been conducted to determine the change of protein component by leucine treatment in intestine epithelial cells.
Xiangbing Mao, Man Ren, Daiwen Chen, Bing Yu, Lianqiang Che, Jun He, Junqiu Luo, Yuheng Luo, Jianping Wang, Hui Sun   +9 more
doaj   +1 more source

Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma [PDF]

, 2010
Background: The enhancer of zeste homolog 2 (EZH2) gene exerts oncogene-like activities and its (over)expression has been linked to several human malignancies. Here, we studied a possible association between EZH2 expression and prognosis in patients with
Johannes Hüsing, Wagener, Nina, Hüsing Johannes, Karin Hoppe-Seyler, Hoppe-Seyler Felix, Peter Schirmacher, Hoppe-Seyler, Karin, Pfitzenmaier, Jesco, Macher-Göppinger, Stephan, Jesco Pfitzenmaier, Hohenfellner, Markus, Hüsing, Johannes, Haferkamp, Axel, Haferkamp Axel, Stephan Macher-Goeppinger, Maria Pritsch, Wagener Nina, Pritsch Maria, Axel Haferkamp, Schirmacher Peter, Nina Wagener, Hoppe-Seyler Karin, Hohenfellner Markus, Felix Hoppe-Seyler, Hoppe-Seyler, Felix, Pfitzenmaier Jesco, Macher-Goeppinger Stephan, Markus Hohenfellner, Pritsch, Maria, Schirmacher, Peter   +29 more
core   +2 more sources

Combined MLH1/MSH2/MSH6 assessment by IHC and RT-qPCR: Differential expression analysis and incremental value for pathological risk stratification in colorectal cancer [PDF]

Journal of Medical Biochemistry
Background: Mismatch repair (MMR) status is routinely assessed in colorectal cancer (CRC), yet the laboratory value of combining multiple MMR targets across platforms for risk stratification requires verification under real-world testing conditions. This
Zhang Yi, Li Xin, Ran Jing, Zuo Ningchuan   +3 more
doaj   +1 more source

Prognostic Significance of ARID1A Expression Patterns Varies with Molecular Subtype in Advanced Gastric Cancer

Gut and Liver, 2023
Background/Aims: AT-rich interactive domain 1A (ARID1A) is frequently mutated in gastric cancer (GC), especially Epstein-Barr virus (EBV)-associated and microsatellite instability high GC.
Jun Yong Kim, Cheol Keun Park, Songmi Noh, Jae-Ho Cheong, Sung Hoon Noh, Hyunki Kim   +5 more
doaj   +1 more source

C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins [PDF]

, 2012
The human DNA mismatch repair (MMR) process is crucial to maintain the integrity of the genome and requires many different proteins which interact perfectly and coordinated.
Hinrichsen, Inga Malena, Stefan Zeuzem, Hinrichsen Inga, Sandra Passmann, Plotz Guido, Adam, Ronja Sophia Mercedes, Plotz, Guido, Zeuzem Stefan, Guido Plotz, Passmann, Sandra, Angela Brieger, Ronja Adam, Brieger, Angela, Inga Hinrichsen, Brieger Angela, Passmann Sandra, Adam Ronja, Zeuzem, Stefan   +17 more
core   +2 more sources

Diagnosis and functional prediction of microbial markers in tumor tissues of sporadic colorectal cancer patients associated with the MLH1 protein phenotype

Frontiers in Oncology, 2023
ObjectiveMost patients with sporadic colorectal cancer (SCRC) develop microsatellite instability because of defects in mismatch repair (MMR). Moreover, the gut microbiome plays a vital role in the pathogenesis of SCRC.
Anchao Zhu, Anchao Zhu, Yingying Liu, Zongmin Li, Ying He, Lijing Bai, Youtian Wu, Yuying Zhang, Ying Huang, Ping Jiang   +9 more
doaj   +1 more source

Characterization of the murine cytomegalovirus genes encoding the major DNA binding protein and the ICP18.5 homolog [PDF]

, 1992
In several herpesviruses the genes for the major DNA binding protein (MDBP), a putative assembly protein, the glycoprotein B (gB), and the viral DNA polymerase (pol) coliocate.
Koszinowski, Ulrich H., Schneider, Karin, Messerle, Martin, Keil, Günther M.   +3 more
core   +1 more source