Results 11 to 20 of about 32,331,402 (154)

Targeting mitochondrial DNA polymerase gamma for selective inhibition of MLH1 deficient colon cancer growth.

PLoS ONE, 2022
Synthetic lethality in DNA repair pathways is an important strategy for the selective treatment of cancer cells without harming healthy cells and developing cancer-specific drugs. The synthetic lethal interaction between the mismatch repair (MMR) protein,
Berna Somuncu, Aysegul Ekmekcioglu, Fatma Merve Antmen, Tugce Ertuzun, Emre Deniz, Nazli Keskin, Joon Park, Ilgu Ece Yazici, Busra Simsek, Batu Erman, Whitney Yin, Burak Erman, Meltem Muftuoglu   +12 more
doaj   +3 more sources

Identification of a novel pathogenic MLH1 mutation and recommended genetic screening strategy: An investigation of three Chinese Lynch syndrome pedigrees

Molecular Genetics & Genomic Medicine, 2020
Background Lynch syndrome (LS) is an autosomal‐dominant disorder that increases the risk of many cancers. The genetic basis of LS is germline mutations in DNA mismatch repair genes.
Fan Li, Yunwei Xia, Guoguang Wang, Chaoyang Tang, Tian Zhan, Jian Shen, Jianping Zhang   +6 more
doaj   +1 more source

Identification of Driving ALK Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer. [PDF]

PLoS Genetics, 2015
The genetic landscape of medullary thyroid cancer (MTC) is not yet fully understood, although some oncogenic mutations have been identified. To explore genetic profiles of MTCs, formalin-fixed, paraffin-embedded tumor tissues from MTC patients were ...
Jun Ho Ji, Young Lyun Oh, Mineui Hong, Jae Won Yun, Hyun-Woo Lee, DeokGeun Kim, Yongick Ji, Duk-Hwan Kim, Woong-Yang Park, Hyun-Tae Shin, Kyoung-Mee Kim, Myung-Ju Ahn, Keunchil Park, Jong-Mu Sun   +13 more
doaj   +1 more source

Expression of PD-L1 in Microsatellite Instability High Tumours: A Retrospective Study [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Microsatellite Instability (MSI) is the hallmark of Lynch syndrome/Constitutional Mismatch Repair Deficiency (CMMRD) and is also found in many sporadic cancers like colorectal cancer, endometrial, gastric, small intestine, urothelial ...
Dinisha Einstien, Gayathri Devi Thanigaimani, KS Mouleeswaran, A Prathiba, G Sarumathy, John Vergilin   +5 more
doaj   +1 more source

Recombination homeostasis of meiosis during spermatogenesis under nicotine treatment [PDF]

Archives of Biological Sciences, 2018
Cigarette smoking can affect male fertility via the quality of semen. To explore the effects of nicotine, a major component of cigarettes, on meiotic recombination during spermatogenesis, C57BL/6J male mice were injected with nicotine at a dosage of 0.2 ...
Zhai Jingli, Yuan Qingqing, Yang Tianqi, Zhao Xianglong, Zhang Meixing, Zhang Dong, Xu Wangjie, Qiao Zhongdong   +7 more
doaj   +1 more source

MLH1 (human mutL homolog 1) [PDF]

, 2005
Review on MLH1 (human mutL homolog 1), with data on DNA, on the protein encoded, and where the gene is ...
Domingo, E, Schwartz, S Jr, S Jr Schwartz, E Domingo   +3 more
core   +1 more source

Overexpression of MutL homolog 1 and MutS homolog 2 proteins have reversed prognostic implications for stage I–II colon cancer patients

Biomedical Journal, 2017
The outcome of colon cancer patients without lymph node metastasis is heterogeneous. Searching for new prognostic markers is warranted.One hundred twenty stage I-II colon cancer patients who received complete surgical excision during 1995-2004 were selected for this biomarker study.
Shih-Chiang Huang, Shiu-Feng Huang, Ya-Ting Chen, Yu Chang, Yu-Ting Chiu, Il-Chi Chang, Hong-Dar Isaac Wu, Jinn-Shiun Chen   +7 more
openaire   +3 more sources

N‐terminus of hMLH1 confers interaction of hMutLα and hMutLβ with hMutSα [PDF]

, 2006
Mismatch repair is a highly conserved system that ensures replication fidelity by repairing mispairs after DNA synthesis. In humans, the two protein heterodimers hMutSα (hMSH2‐hMSH6) and hMutLα (hMLH1‐hPMS2) constitute the centre of the repair reaction ...
Trojan, Jörg, Brieger, Angela, Raedle, Jochen, Plotz, Guido, Zeuzem, Stefan   +4 more
core   +1 more source

Clinical significance of chromodomain helicase/ATPase DNA binding protein 1‑like and human mutL homolog�1 gene expression in cholangiocarcinoma

Oncology Letters, 2018
Cholangiocarcinoma is a highly malignant form of gastrointestinal cancer with an unfavorable prognosis. The novel oncogene chromodomain helicase/ATPase DNA binding protein 1-like (CHD1L) has been confirmed to serve a vital role in numerous types of cancer, including liver cancer.
Hua, Jingwen, Li, Shiniao, Huang, Changwen   +2 more
openaire   +3 more sources

MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her‐2/PI3K/AKT Signaling

Advanced Science, 2020
The rapid onset of resistance to cetuximab (CTX) limits its clinical utility in colorectal cancer (CRC) patients. This study aims to understand a potential role of mismatch repair gene mutL homolog 1 (MLH1) in CTX response. Functional analysis of MLH1 in
Ying Han, Yinghui Peng, Yaojie Fu, Changjing Cai, Cao Guo, Shanshan Liu, Yiyi Li, Yihong Chen, Edward Shen, Kexin Long, Xinwen Wang, Jian Yu, Hong Shen, Shan Zeng   +13 more
doaj   +1 more source