Additional file 2 of Comparative transcriptomic analysis of reproductive characteristics of reciprocal hybrid lineages derived from hybridization between Megalobrama amblycephala and Culter alburnus [PDF]
, 2023 Additional file 2: Fig. S1. Expression profiles of differentially expressed genes from RNA-Seq validated by qRT-PCR. A.Validation results for BT vs BSB and BT vs TC. B.Validation results for TB vs BSB and TB vs TC.
Yifei Zhang (122595) +6 more
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MLH1 (human mutL homolog 1) [PDF]
, 2005 Review on MLH1 (human mutL homolog 1), with data on DNA, on the protein encoded, and where the gene is ...
Domingo, E +3 more
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Les homologues de MutS et de MutL au cours de la méiose chez les mammifères [PDF]
, 2003 La recombinaison méiotique correspond à des échanges réciproques de matériel génétique entre les chromosomes homologues maternels et paternels. Ces échanges sont nécessaires à la ségrégation correcte des chromosomes homologues lors de la première ...
Sabine Santucci-Darmanin +3 more
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Structure of the MutL$\alpha$ C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site. [PDF]
, 2013 International audienceMismatch-repair factors have a prominent role in surveying eukaryotic DNA-replication fidelity and in ensuring correct meiotic recombination. These functions depend on MutL-homolog heterodimers with Mlh1.
Le Du, Marie-Hélene +27 more
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Molecular Basis of Mismatch Repair Protein Deficiency in Tumors from Lynch Suspected Cases with Negative Germline Test Results [PDF]
, 2020 Some 10–50% of Lynch-suspected cases with abnormal immunohistochemical (IHC) staining remain without any identifiable germline mutation of DNA mismatch repair (MMR) genes.
Eldfors, Samuli +15 more
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Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast [PDF]
, 2000 The DNA mismatch repair machinery is involved in the correction of a wide variety of mutational intermediates. In bacterial cells, homodimers of the MutS protein bind mismatches and MutL homodimers couple mismatch recognition to downstream processing ...
Minesinger, Brenda K. +5 more
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The Genomics of colorectal cancer: State of the art [PDF]
, 2008 The concept of the adenoma-carcinoma sequence, as first espoused by Morson et al. whereby the development of colorectal cancer is dependent on a stepwise progression from adenomatous polyp to carcinoma is well documented.
Hodgson, SV +3 more
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mutation and recommended genetic screening strategy: An investigation of three Chinese Lynch syndrome pedigrees [PDF]
, 2020 Background Lynch syndrome (LS) is an autosomal‐dominant disorder that increases the risk of many cancers. The genetic basis of LS is germline mutations in DNA mismatch repair genes.
Fan Li +6 more
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Family of SRY/Sox proteins is involved in the regulation of the mouseMsh4 (MutS homolog 4) gene expression [PDF]
, 2001 International audienceThe eukaryotic MutHLS-like system plays a crucial role in both mitosis and meiosis. Until now, a number of works have focused on the function of MutS and MutL homologs during mismatch DNA repair.
Scimeca, Jean-Claude +9 more
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DataSheet_1_Diagnosis and functional prediction of microbial markers in tumor tissues of sporadic colorectal cancer patients associated with the MLH1 protein phenotype.zip [PDF]
, 2023 ObjectiveMost patients with sporadic colorectal cancer (SCRC) develop microsatellite instability because of defects in mismatch repair (MMR). Moreover, the gut microbiome plays a vital role in the pathogenesis of SCRC.
Yingying Liu (360782) +8 more
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