Results 11 to 20 of about 8,700 (159)
Expression of PD-L1 in Microsatellite Instability High Tumours: A Retrospective Study [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Microsatellite Instability (MSI) is the hallmark of Lynch syndrome/Constitutional Mismatch Repair Deficiency (CMMRD) and is also found in many sporadic cancers like colorectal cancer, endometrial, gastric, small intestine, urothelial ...
Dinisha Einstien +5 more
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Molecular Genetics & Genomic Medicine, 2020 Background Lynch syndrome (LS) is an autosomal‐dominant disorder that increases the risk of many cancers. The genetic basis of LS is germline mutations in DNA mismatch repair genes.
Fan Li +6 more
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Identification of Driving ALK Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer. [PDF]
PLoS Genetics, 2015 The genetic landscape of medullary thyroid cancer (MTC) is not yet fully understood, although some oncogenic mutations have been identified. To explore genetic profiles of MTCs, formalin-fixed, paraffin-embedded tumor tissues from MTC patients were ...
Jun Ho Ji +13 more
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Recombination homeostasis of meiosis during spermatogenesis under nicotine treatment [PDF]
Archives of Biological Sciences, 2018 Cigarette smoking can affect male fertility via the quality of semen. To explore the effects of nicotine, a major component of cigarettes, on meiotic recombination during spermatogenesis, C57BL/6J male mice were injected with nicotine at a dosage of 0.2 ...
Zhai Jingli +7 more
doaj +1 more source
Genetic pathways, prevention, and treatment of sporadic colorectal cancer [PDF]
, 2014 Epithelial cancer of the colon and rectum, also known as colorectal cancer (CRC), results from a progressive accumulation of genetic and epigenetic alterations that lead to uncontrolled growth of colonocytes, the cells lining the colon and rectum. CRC is
Imperiale, Thomas F. +4 more
core +6 more sources
Biomedical Journal, 2017 The outcome of colon cancer patients without lymph node metastasis is heterogeneous. Searching for new prognostic markers is warranted.One hundred twenty stage I-II colon cancer patients who received complete surgical excision during 1995-2004 were selected for this biomarker study.
Shih-Chiang Huang +7 more
openaire +3 more sources
Phage inducible islands in the gram-positive cocci [PDF]
, 2016 The SaPIs are a cohesive subfamily of extremely common phage-inducible chromosomal islands (PICIs) that reside quiescently at specific att sites in the staphylococcal chromosome and are induced by helper phages to excise and replicate.
A Bolotin +47 more
core +1 more source
Oncology Letters, 2018 Cholangiocarcinoma is a highly malignant form of gastrointestinal cancer with an unfavorable prognosis. The novel oncogene chromodomain helicase/ATPase DNA binding protein 1-like (CHD1L) has been confirmed to serve a vital role in numerous types of cancer, including liver cancer.
Hua, Jingwen +2 more
openaire +3 more sources
MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her‐2/PI3K/AKT Signaling
Advanced Science, 2020 The rapid onset of resistance to cetuximab (CTX) limits its clinical utility in colorectal cancer (CRC) patients. This study aims to understand a potential role of mismatch repair gene mutL homolog 1 (MLH1) in CTX response. Functional analysis of MLH1 in
Ying Han +13 more
doaj +1 more source
The Prediction of the Expected Current Selection Coefficient of Single Nucleotide Polymorphism Associated with Holstein Milk Yield, Fat and Protein Contents [PDF]
Asian-Australasian Journal of Animal Sciences, 2016 Milk-related traits (milk yield, fat and protein) have been crucial to selection of Holstein. It is essential to find the current selection trends of Holstein. Despite this, uncovering the current trends of selection have been ignored in previous studies.
Young-Sup Lee +6 more
doaj +1 more source